Search results for "ROMA"
showing 10 items of 13919 documents
Síntesis de biodiésel y caracterización de bebidas alcohólicas mediante técnicas de elevada resolución
2015
En esta Tesis Doctoral se describe el desarrollo de procedimientos de síntesis de biodiésel y caracterización de bebidas alcohólicas mediante técnicas analíticas de elevada resolución. La puesta a punto de los procedimientos de síntesis de biodiésel y sus estudios de caracterización se realizó en respuesta a la demanda de producción de biocombustibles basados en materias primas renovables y de bajo impacto ambiental que puedan reemplazar de manera efectiva al diésel convencional obtenido a partir de fuentes fósiles. Otro de los aspectos descritos en esta Tesis, y entroncando con una de las líneas actuales de investigación del grupo, es la caracterización de proteínas en diversos extractos v…
cis-Regulation and chromatin dynamics of the hbox12 gene during the embryogenesis of Paracentrotus lividus.
2014
The GRN specifying the dorsal-ventral (D-V) axis of the sea urchin embryo is currently under investigation. An early input for D-V polarity is given by a redox gradient probably generated by an asymmetrical distribution of maternal mitochondria (1). Only on the future ventral side, the oxidizing environment induces the expression of the nodal gene, an essential regulator of D-V polarization (2). By contrast, on the future dorsal side, a reducing environment activates the hypoxia inducible factor (HIF-1α) (3). The hbox12 transcription repressor is an early marker of the dorsal side of the embryo, in which it negatively regulates the expression of nodal (4, 5). Interestingly, by in silico ana…
Genome wide mapping of the MBF-1 binding sites during embryogenesis of the sea urchin reveals it is a chromatin organizer.
2015
The Zinc-finger MBF1 factor is a transcription activator involved in the expression of the early histone genes during development of the sea urchin embryo (1). The DNA-binding domain of MBF1 shares high sequence similarity with that of the CTCF chromatin organizer but, unexpectedly, extensive in silico analysis failed to identify the sea urchin CTCF ortholog (2, 3). This led us to speculate that MBF1 could have co-opted the function of CTCF during evolution of the echinoderms. To support this hypothesis, we performed the genome-wide MBF1-binding sites mapping in the P. lividus genome, by chromatin immunoprecipitation coupled to next generation sequencing (ChIP-Seq). We observed that MBF1 bi…
Chromatin dynamics during sea urchin embryogenesis: effects on the neural alpha tubulin PlTa2 gene expression
2011
Expression of PlTa2 gene during sea urchin P. lividus development, is spatially confined to the neural territory and temporally activated from the blastula stage. To evaluate a possible involvement of chromatin modifications in regulation of PlTa2 gene expression we first searched for DNaseI hypersentive sites. We found four sites localized in the introns of the gene, when we used chromatin extracted from embryos at gastrula stage but not from morula stage. This result suggests a possible functional role of the introns in the activation of the expression of PlTa2 gene. Moreover, we used specific antibodies for RNA polymerase II and for different modified form of lysine 9, lysine 27 and lysi…
NEW RESTORED DENARIUS OF TRAJAN FROM CARCABOSO, CÁCERES (CONVENTUS EMERITENSIS, LUSITANIA)
2019
A recent and new Republican denarius restored by Trajan is studied and discussed. The issue is extremely rare as no image of it is known so far. It was found in Carcaboso, Cáceres (Conventus Emeritensis, Lusitania), very near of the road known as Vía de la Plata, very surely in a Roman mansio.
Nuevas faunas de micromamíferos del Terciario continental de la Depresión Intermedia (provincia de Cuenca, España centro-oriental)
1986
In this paper the fossil content of nine new micromammal bearing localities and that of 15 levels in a borehole from the Loranca Basin (eastern Tague Basin, Prov. of Cuenca) is described. The age ranges from early Arvernian (Late Oligocene) to Turolian (Late Miocene). 47 rodent and lagomorph taxons have been found which are arranged in 8 biostratigraphic units. The Loranca-2 borehole contains 15 fossiliferous levels covering the Upper Oligocene/Lower Miocene. These additional data complete the faunal sequence published by Díaz & López(1919). The stratigraphic framework of the basin needs a revision because of the new faunal data.<br><br>Se presenta una serie de 9 nuevos yaci…
Western mediterranean archaeology: chemical element levels in archaeological materials as a methodological tool
2014
Una línea de desarrollo de las investigaciones arqueométricas, objeto de nuestro estudio, que presenta un amplia gama de potenciales aplicaciones metodológicas, al día de hoy conocidas solo en parte, es el análisis de los elementos químicos metálicos y no metálicos, ya sean los elementos mayoritarios, los elementos trazas y, más recientemente, los conocidos como “tierras raras” (por su nombre en inglés, Rare Earth Elements - REEs), que se han revelado útiles en nuestro estudio para la solución de algunos problemas arqueológicos. La posibilidad de poder actuar de forma sistemática, ha ayudado, por un lado, a conocer y desarrollar el potencial de estos elementos y, por otro, ha servido de sop…
Selluloosajohdannaisten rakenteen ja substituutioasteen tutkiminen
2016
Nykyään ympäristöystävällisille, biohajoaville ja uusiutuvista luonnonvaroista valmistetuille tuotteille on suuri kysyntä. Tämän takia erilaiset selluloosan johdannaiset ovat kiinnostavia. Näistä karboksimetyyliselluloosa on eniten käytetty vesiliukoinen selluloosan eetteri. Tässä pro gradu -tutkielmassa käsiteltiin karboksimetyyliselluloosan selluloosarakenteen ja substituutioasteen tutkimuksessa hyödynnettäviä analyysimenetelmiä. Kromatografiset ja spektroskopiset menetelmät ovat tärkeimpiä selluloosarungon tutkimuksessa. Substituutioaste voidaan määrittää esimerkiksi perinteisillä titrausmenetelmillä. Substituutioastejakaumaa puolestaan voidaan tutkia nestekromatografisesti.
Fundamentos físicos de la informática (2009/10)
2009
Enigma, suspense, dilemma. Valori e modalità di lettura del giorno della civetta
2020
The paper presents a close reading of The Day of the Owl originating f rom the perspective of semiotic literary theory. It is possible to observe three strategies in the text: enigma, suspense, and dilemma. Whereas the first two cover the unmasking of the truth – following the tradition in crime novels –, the third strategy is particular to the Sciascian contextual crime novel, focused on the semantic instability of values that are the foundation of the social contract. From this starting point, this essay seeks to show that the ‘first novel on Mafia’ is also the first novel that tackles the issue of the Anti-Mafia.