Search results for "ROUGH"
showing 10 items of 1198 documents
Translational readthrough of ciliopathy genes BBS2 and ALMS1 restores protein, ciliogenesis and function in patient fibroblasts
2021
Abstract Background Ciliary dysfunction underlies a range of genetic disorders collectively termed ciliopathies, for which there are no treatments available. Bardet-Biedl syndrome (BBS) is characterised by multisystemic involvement, including rod-cone dystrophy and renal abnormalities. Together with Alstrom syndrome (AS), they are known as the ‘obesity ciliopathies’ due to their common phenotype. Nonsense mutations are responsible for approximately 11% and 40% of BBS and AS cases, respectively. Translational readthrough inducing drugs (TRIDs) can restore full-length protein bypassing in-frame premature termination codons, and are a potential therapeutic approach for nonsense-mediated ciliop…
Performance Assessment of Building Integrated Photovoltaic and Battery Energy System: A Case Study of TERI-Retreat Facilty in India
2019
Building integrated photovoltaic (BIPV) with energy storage can play an important role not only in demand side management but also in a micro-grid system in coordination with other distributed generators. The operational analysis of BIPV system and energy storage with contribution to local load profile is needed for its grid connected operation, as well as for integrating it in the micro-grid system. In this work, a typical institution has been selected, where the PV system and energy storage are operated for supplying local load in coordination with the grid. The institutional load profile has been analyzed with essential and non-essential loads for understanding the operation and contribu…
Using coded excitation to maintain signal to noise for FMC+TFM on attenuating materials
2019
Ultrasonic Non-Destructive Evaluation using Full Matrix Capture (FMC) and Total Focusing Method (TFM) is used for high resolution imaging as every pixel is in optimal focus. FMC excites one element in turn, so operates with lower transmitted energy compared to phased array beamforming. The energy at a reflector is further reduced by the broad directivity pattern of the single element. The large number of Tx/Rx A-scans that contribute to each pixel recover the Signal-to-Noise Ratio (SNR) in the final TFM image. Maintaining this in the presence of attenuating materials is a challenge because relevant information in each A-scan signal is buried in the thermal noise, and the TFM process assumes…
Clustering-Assisted 3D Beamforming for Throughput Maximization in mmWave Networks
2021
Beamforming schemes have been widely used to improve network throughput in 5G mmWave networks. However, 3D beamforming schemes have hereto not been investigated in this context. In this work, a cluster-assisted 3D beamforming scheme is proposed to optimize the downtilt angle for network coverage and throughput maximization. User Equipment (UEs) are clustered based on inter-user and the inter-cluster distances. The interference is accounted from the adjacent clusters and thus frequency resources can be assigned to the non-adjacent clusters. Optimal downtilt angles are obtained for every cluster to maximize the throughput while considering the interference from adjacent clusters. 3D beam patt…
Enable concurrent transmissions with beamforming for broadband wireless access in CSMA/CA-based WLANs
2014
In CSMA/CA based wireless local networks, two stations are not allowed to transmit at the same time due to interference generated to each other, resulting in degraded throughput. Concurrent transmission, which enables simultaneous transmission of two or more stations under certain conditions, is able to overcome this problem, leading to enhanced channel utilization efficiency. Different from earlier work on this topic which focuses on omni-direction concurrent transmission, we introduce in this paper beamforming into a co-channel concurrent transmission scheme and investigate the benefits of concurrency with beamforming. The circumstances for concurrent transmission and frame scheduling are…
Overland flow hydrodynamic characteristics in rough beds at low Reynolds numbers
2022
This paper considers overland flow resistance at low Reynolds numbers through analysis of experimental runs carried out using water only and water/glycerol mixtures. We first examined the power relationship between the Darcy–Weisbach friction factor f and the Reynolds number Re to obtain the values of the K coefficient and b exponent. These results confirmed the applicability of the values of b suggested in literature, while K required a specific calibration for laminar open-channel flows. The analysis revealed that transition from a laminar to turbulent flow regime for water only flows occurred at a threshold value of Re equal to 500 as described historically. The estimate of f by the powe…
Experimental observations of upstream overdeepening
2005
The issue of morphodynamic influence in meandering streams is investigated through a series of laboratory experiments on curved and straight flumes. Both qualitative and quantitative observations confirm the suitability of the recent theoretical developments (Zolezzi & Seminara 2001) that indicate the occurrence of two distinct regimes of morphodynamic influence, depending on the value of the width ratio of the channel β. The threshold value βR separating the upstream from the downstream influence regimes coincides with the resonant value discovered by Blondeaux & Seminara (1985). Indeed it is observed that upstream influence may occur only in relatively wide channels, while narrower stream…
Surface finish on hardened bearing steel parts produced by superhard and abrasive tools
2007
New technological process consisting of hard turning (HT) followed by abrasive machining, in place of the widely used method in industry, i.e., hard turning versus grinding, has lately been launched in the automotive industry. This is because, many transmissions parts, such as synchronizing gears, crankshafts and camshafts require superior surface finish along with appropriate fatigue performance. This paper provides a comprehensive characterization of part surface finish produced in dry turning of a hardened AISI 52100 bearing steel using mixed ceramic (MC) and PCBN tools, and also its modification after special abrasive finishing operations including superfinishing (SF) and belt grinding …
Antigüedad clásica y cultura nobiliaria en la España de finales del siglo XVIII. Autores y ediciones greco-romanas en la biblioteca de José Alvarez d…
2019
This article analyzes the reception of the classical world in the Spanish nobiliary culture at the end of the 18th century. Our objective is materialized through the study of the Greco-Roman books present in the unpublished catalog of the library of José Álvarez de Toledo, 11th Marqués de villafranca. From the examination of the authors and the different editions conserved by the aristocrat, the work tries to examine the influence of the classical world and its actuality in the development of the most advanced nobiliary culture of eighteenth- century Spain.
Surface soil moisture retrieval using L-band SMAP SAR data and its validation
2016
Surface soil moisture was retrieved globally by systematically correcting for the effects of vegetation and soil surface roughness. The retrieval is enabled by employing physical-models of radar forward scattering for individual vegetation types to account for vegetation scattering and absorption, and by constraining the surface roughness effect using time-series observations. The L-band SMAP multi-polarized (HH/VV/HV) σ° data acquired globally every three days were used from mid-April to early July, 2015. Assessment was conducted over 13 rigorously-chosen core validation sites covering a wide range of biomass types, biomass amount, and soil conditions. The soil moisture retrieval reached a…