Search results for "ROUTE"
showing 10 items of 196 documents
New Prospectives in the Delivery of Galantamine for Elderly Patients Using the IntelliDrug Intraoral Device: In Vivo Animal Studies
2009
The transbuccal delivery of drugs could assist several categories of chronic, especially elderly, patients in adhering to a correct dosage regimen. In particular, patients suffering from dementia have several difficulties in following the prescribed dosage, in addition to problems associated with swallowing tablets. Galantamine is currently used for treating patients with mild to moderate Alzheimer's-type dementia. The transbuccal delivery of this drug could be an interesting non- invasive and safe administration route. Several studies have been performed in vitro and ex vivo within the framework of a European Commission funded Project (IntelliDrug-FP6), aimed at developing a device which w…
Fog Computing based traffic Safety for Connected Vulnerable Road Users
2019
Annually, millions of people die and many more sustain non-fatal injuries because of road traffic crashes. Despite multitude of countermeasures, the number of causalities and disabilities owing to traffic accidents are increasing each year causing grinding social, economic, and health problems. Due to their high volume and lack of protective-shells, more than half of road traffic deaths are imputed to vulnerable road users (VRUs): pedestrians, cyclists and motorcyclists. Mobile devices combined with fog computing can provide feasible solutions to protect VRUs by predicting collusions and warning users of an imminent traffic accident. Mobile devices’ ubiquity and high computational capabilit…
What is the impact of rerouting a cancer diagnosis from emergency presentation to GP referral on resource use and survival? Evidence from a populatio…
2018
Background Studies on alternative routes to diagnosis stimulated successful policy interventions reducing the number of emergency diagnoses and associated mortality risk. A dearth of evidence on the costs of such interventions might prevent new policies from achieving more ambitious targets. Methods We conducted a retrospective cohort study on the population of colorectal (88,051), breast (90,387), prostate (96,219), and lung (97,696) cancer patients diagnosed after a GP referral or an emergency presentation and reported in the Cancer Registry of England. Resource use and survival were compared 1 year before and 5 years after diagnosis (3 years for lung), including the costs of GP referrals…
Real-time weighting optimization in Chinese Postman Problem
2013
International audience; In this study, based on real-time constraint, an optimization method is proposed for solving the problem of the optimal tour. For that, we will construct a graph containing the real-time state of traffic. The collected data will be used to predict the future state traffic and to give an optimized cost of the tour. This optimization is tested in different sizes of the road networks. The results show that the proposed method is efficient and effective in solving the Chinese Postman Problem in real-time.
Understanding maritime transport route choice among Irish exporters: A latent class approach
2021
Abstract The reduction in the level of maritime connectivity between Ireland and mainland Europe has been the focus of concern for Irish exporters since the withdrawal of the United Kingdom from the European Union in January 2019. In a post-Brexit scenario, new proposals are being sought to address Ireland's reliance on the UK land-bridge. Policy developments aimed at circumventing the potential negative impact of UK customs checks for Irish exports include the proposals by the European Commission to introduce new direct shipping routes connecting main ports in Ireland with Zeebrugge and Antwerp in Belgium, as well as with Rotterdam in the Netherlands. From a transport policy perspective, f…
Joint Route Planning under Varying Market Conditions
2006
Purpose - To provide empirical evidence on the level of savings that can be attained by joint route planning and how these savings depend on specific market characteristics.Design/methodology/approach - Joint route planning is a measure that companies can take to decrease the costs of their distribution activities. Essentially, this can either be achieved through horizontal cooperation or through outsourcing distribution to a Logistics Service Provider. The synergy value is defined as the difference between distribution costs in the original situation where all entities perform their orders individually, and the costs of a system where all orders are collected and route schemes are set up s…
Introduzione, in [Meridiana : rivista di storia e scienze sociali : 92, 2, 2018].
2018
The period between the two World Wars marks the end of mass emigration for Italy. In the course of thirty years, the migratory flows were transformed: the number of starters was reduced and the trajectories changed. The new restrictions established by immigration countries – (e.g. the Quota Acts in the Twenties) – and the advent of the fascist regime redesigned the paths of Italian emigrants. At first, Mussolini gathered the legacy of liberal governments; then, since the end of the Twenties, he inaugurated a new migration policy, in line with the demographic policy of the regime and strengthening the link between emigration and foreign policy. As the historian Bertonha wrote, emigration bec…
In vivo toxicity studies of fusarium mycotoxins in the last decade: a review.
2015
This review summarizes the information regarding the in vivo studies of Fusarium mycotoxins in the last decade. The most common studies are classified as subacute toxicity, subchronic toxicity, acute toxicity, toxicokinetic studies and teratogenicity in order of importance. The most used animals in in vivo studies are pigs, rats, chickens and mice. Fumonisin B1, deoxynivalenol, zearalenone, nivalenol and T-2 toxin are the most studied fusarotoxins. Studies with combinations of mycotoxins are also frequent, deoxynivalenol generally being one of them. The predominant route of administration is oral, administered mostly in the form of naturally contaminated feed. Other administration routes al…
A GIS-Based Method for Analysing the Association Between School-Built Environment and Home-School Route Measures with Active Commuting to School in U…
2020
In the current call for a greater human health and well-being as a sustainable development goal, to encourage active commuting to and from school (ACS) seems to be a key factor. Research focusing on the analysis of the association between environmental factors and ACS in children and adolescents has reported limited and inconclusive evidence, so more knowledge is needed about it. The main aim of this study is to examine the association between different built environmental factors of both school neighbourhood and home-school route with ACS of children and adolescents belonging to urban areas. The ACS level was evaluated using a self-reported questionnaire. Built environment variables (i.e.,…
Potencialidades de Google Maps en la investigación social aplicada
2019
In recent years, Google has devoted resources to build a complete map of the world. They constantly scan the territory, collecting a large amount of data that provides updated and complete geographic information. This allows us to have an interoperable map that provides the end user with a search tool, not only of routes but also of shops, equipment and any type of geo-referenced information. In addition, Google Maps provides a series of Application Programming Interface (API), which provides a library of set of subroutines, functions and procedures (in object-oriented programming) that can be used by other software to automate the extraction of information of the Google platform. These fre…