Search results for "ROV"

Evaluation of bintrafusp alfa, a bifunctional fusion protein targeting TGF-β and PD-L1, in cervical cancer: Data from phase 1 and phase 2 studies.

2021

5509 Background: The accelerated FDA approval of pembrolizumab validated the efficacy of anti–PD-(L)1 therapy for pts with recurrent/metastatic cervical cancer; however, the objective response rate (ORR) with pembrolizumab was 14.3% in pts with PD-L1 expressing tumors. HPV infection is implicated in > 95% of cervical cancers and is linked to upregulation of TGF-β signaling. Bintrafusp alfa is a first-in-class bifunctional fusion protein composed of the extracellular domain of the TGF-βRII receptor (a TGF-β “trap”) fused to a human IgG1 mAb blocking PD-L1. We report pooled safety and efficacy in pts with immune checkpoint inhibitor–naive, recurrent/metastatic cervical cancer treated with…

Five-year experience with combined operative and radiotherapeutic treatment of recurrent gynecologic tumors infiltrating the pelvic wall

1996

BACKGROUND. Whereas 25 to 50% of selected patients with gynecologic tumors who relapse centrally in an irradiated pelvis can be salvaged by exenteration, postirradiation recurrence infiltrating the pelvic side wall generally has been fatal. We have designed the combined operative and radiotherapeutic treatment (CORT) procedure for the treatment of postirradiation recurrence infiltrating the pelvic wall and developed several new techniques for its realization. The aim of the surgery is as follows : (1) total resection of the tumor with only a microscopic margin (R1) at the pelvic wall, preserving the bony pelvis and the neurovascular support of the leg ; (2) modulation of the therapeutic ind…

A fatal iatrogenic right vertebral injury after transoral odontoidectomy and posterior cervical stabilization for a type II odontoid fracture.

2014

Abstract The authors present a singular case of an iatrogenic right vertebral artery injury, involving a 67 year-old man, who reported a type II odontoid fracture (Anderson and D'Alonzo Classification) and posterior atlantoaxial dislocation following a road traffic accident. A small injury involving the right vertebral artery occurred as a consequence of transoral odontoidectomy and posterior cervical stabilization. It was caused by bone spicules of spinal origin and their presence was confirmed by the histological section of the right vertebral artery at the level of C1–C2. The case confirms how iatrogenic vertebral artery injuries during cervical spine surgery may be potentially lethal, e…

Olpes pintados de Época Imperial en la provincia de Alicante

1987

Inventario y estudio de las jarras de cerámica romana, de tipo olpe, descubiertas en la provincia de Alicante hasta 1986. Estudio tipológico y decorativo.

Improving the accuracy of rainfall prediction using a regionalization approach and neural networks

2018

Spatial and temporal analysis of precipitation patterns has become an intense research topic in contemporary climatology. Increasing the accuracy of precipitation prediction can have valuable results for decision-makers in a specific region. Hence, studies about precipitation prediction on a regional scale are of great importance. Artificial Neural Networks (ANN) have been widely used in climatological applications to predict different meteorological parameters. In this study, a method is presented to increase the accuracy of neural networks in precipitation prediction in Chaharmahal and Bakhtiari Province in Iran. For this purpose, monthly precipitation data recorded at 42 rain gauges duri…

<title>Statistical bandwidth allocation for multiservice networks</title>

2002

Multiservice networks will carry di erent kinds of applications in the near future. Bandwidth requirements change rapidly, and the network resource management will play an important role to guarantee the use of the limited resources in the most eAEcient way. We approach the channel capacity allocation problem by developing an SLA (Service Level Agreement) based channel allocation method. In our model, the channel may be wired or wireless, so this method can be adapted in multi-technique networks. The algorithm allocates resources to several di erent service classes via several di erent capacity routes. Service provider perfroms optimization by allocating data rate in such a way that the sat…

Path integral solution for non-linear system enforced by Poisson White Noise

2008

Abstract In this paper the response in terms of probability density function of non-linear systems under Poisson White Noise is considered. The problem is handled via path integral (PI) solution that may be considered as a step-by-step solution technique in terms of probability density function. First the extension of the PI to the case of Poisson White Noise is derived, then it is shown that at the limit when the time step becomes an infinitesimal quantity the Kolmogorov–Feller (K–F) equation is fully restored enforcing the validity of the approximations made in obtaining the conditional probability appearing in the Chapman Kolmogorov equation (starting point of the PI). Spectral counterpa…

Working Principles of Perovskite Solar Cells

2018

La syndicalisation des cheminots français. Fin ou résistance d’un « bastion ».

2013

International audience; Sans revenir sur les évolutions de la syndicalisation – tant en France ou, plus globalement, en Europe –, ni sur ses analyses, il apparaît que celle-ci aurait assez bien résisté dans le secteur ferroviaire, souvent présenté, dans le cas français à tout le moins, comme une sorte de « bastion » syndical, lequel est également invoqué pour expliquer la « combativité » des cheminots.On peut naturellement supposer que cette plus forte propension à « se mobiliser » est liée notamment à un niveau d’engagement syndical – notamment dans des organisations contestataires – qui resterait beaucoup plus élevé que dans les autres secteurs de l’économie. Ce n’est sans aucun doute pas…

Thermodynamic stability of stoichiometric LaFeO 3 and BiFeO 3 : a hybrid DFT study

2017

BiFeO3 perovskite attracts great attention due to its multiferroic properties and potential use as a parent material for Bi1−xSrxFeO3−δ and Bi1−xSrxFe1−yCoyO3−δ solid solutions in intermediate temperature cathodes of oxide fuel cells. Another iron-based LaFeO3 perovskite is the end member for well-known solid solutions (La1−xSrxFe1−yCoyO3−δ) used for oxide fuel cells and other electrochemical devices. In this study an ab initio hybrid functional approach was used for the study of the thermodynamic stability of both LaFeO3 and BiFeO3 with respect to decompositions to binary oxides and to elements, as a function of temperature and oxygen pressure. The localized (LCAO) basis sets describing th…