Search results for "RULE"
showing 10 items of 1403 documents
Pga26 mediates filamentation and biofilm formation and is required for virulence in Candida albicans
2011
The Candida albicans gene PGA26 encodes a small cell wall protein and is upregulated during de novo wall synthesis in protoplasts. Disruption of PGA26 caused hypersensitivity to cell wall-perturbing compounds (Calcofluor white and Congo red) and to zymolyase, which degrades the cell wall β-1,3-glucan network. However, susceptibility to caspofungin, an inhibitor of β-1,3-glucan synthesis, was decreased. In addition, pga26Δ mutants show increased susceptibility to antifungals (fluconazol, posaconazol or amphotericin B) that target the plasma membrane and have altered sensitivities to environmental (heat, osmotic and oxidative) stresses. Except for a threefold increase in β-1,6-glucan and a sl…
The Candida albicans pH-regulated KER1 gene encodes a lysine/glutamic-acid-rich plasma-membrane protein that is involved in cell aggregation.
2004
Immunoscreening of aCandida albicanscDNA library with a polyclonal germ-tube-specific antibody (pAb anti-gt) resulted in the isolation of a gene encoding a lysine/glutamic-acid-rich protein, which was consequently designatedKER1. The nucleotide and deduced amino acid sequences of this gene displayed no significant homology with any other known sequence.KER1encodes a 134 kDa lysine (14·5 %)/glutamic acid (16·7 %) protein (Ker1p) that contains two potential transmembrane segments.KER1was expressed in a pH-conditional manner, with maximal expression at alkaline pH and lower expression at pH 4·0, and was regulated byRIM101. A Δker1/Δker1null mutant grew normally but was hyperflocculant under ge…
Exploring new roles for the rpoS gene in the survival and virulence of the fire blight pathogen Erwinia amylovora
2014
Erwinia amylovora causes fire blight in economically important plants of the family Rosaceae. This bacterial pathogen spends part of its life cycle coping with starvation and other fluctuating environmental conditions. In many Gram-negative bacteria, starvation and other stress responses are regulated by the sigma factor RpoS. We obtained an E. amylovora rpoS mutant to explore the role of this gene in starvation responses and its potential implication in other processes not yet studied in this pathogen. Results showed that E. amylovora needs rpoS to develop normal starvation survival and viable but nonculturable (VBNC) responses. Furthermore, this gene contributed to stationary phase cross-…
Para una historia de la administración italiana. Del Estado liberal al Estado fascista
2018
The origins of the Italian Public Administration date back to a time prior to the political birth of Italy. Its history follows an itinerary based on gradual modifications in correspondence with economic, social, political and cultural changes. Between the 19th and the 20th Century, the Italian Public Administration played several roles. Going from being a political instrument to a means of social intervention and/or a vehicle of economic direction, the Italian Public Administration drew its own structures and modified its own roles, according with the constitutional development that leaded Italy from the liberal State to the fascist State. But there was also a technical continuity, which p…
Diritto naturale e liberalismo. Dialogo o conflitto?
2009
Confronto fra diritto naturale e liberalismo in tema di rule of law e di etica delle virtù
Hints from the Crowd: A Novel NoSQL Database
2013
The crowd can be an incredible source of information. In particular, this is true for reviews about products of any kind, freely provided by customers through specialized web sites. In other words, they are social knowledge, that can be exploited by other customers. The Hints From the Crowd HFC prototype, presented in this paper, is a NoSQL database system for large collections of product reviews; the database is queried by expressing a natural language sentence; the result is a list of products ranked based on the relevance of reviews w.r.t. the natural language sentence. The best ranked products in the result list can be seen as the best hints for the user based on crowd opinions the revi…
Regole. Un saggio di psicodeontica
2022
In this article, I first introduce a naturalistic method of inquiry in meta-normative issues, that, following a suggestion by B. Celano, I call “psychodeontics”. I then provide an example of how the method works, focusing on three aspects of the phenomenon of rules and rule-guided behaviour: the fact that rules are reasons for action, the relation between rules and habits, and the “entrenchment” of rules.
Neuronal populations mediating the effects of endocannabinoids on stress and emotionality
2011
An adequate emotional response to stress is essential for survival and requires the fine-tuned regulation of several distinct neuronal circuits. Therefore, a precise control of these circuits is necessary to prevent behavioral imbalances. During the last decade, numerous investigations have evidenced that the endocannabinoid (eCB) system is able to crucially control stress coping. Its central component, the cannabinoid type 1 receptor (CB1 receptor), is located at the presynapse, where it is able to attenuate neurotransmitter release after its activation by postsynaptically produced and released eCBs. To date, the eCB system has been found to control the neurotransmitter release from severa…
Peripheral CB1 receptor blockade acts as a memory enhancer through an adrenergic-dependent mechanism
2021
Peripheral inputs to the brain continuously shape its function and can influence the formation of non-emotional memory, but the underlying mechanisms have not been fully understood. Cannabinoid type-1 receptors (CB1R), widely distributed in the organism, is a well-recognized player in memory performance, and its systemic modulation significantly influences memory function. By assessing non-emotional memory in mice, we have now found a relevant role of peripheral CB1R in the formation of persistent memory. Indeed, peripherally restricted CB1R antagonism by using AM6545 showed a mnemonic effect that was occluded in adrenalectomized mice, after peripheral adrenergic blockade, or when vagus ner…
Norme sulla tutela dell'ambiente nelle poleis greche di età pre-ellenistica
2020
This paper offers a study of fifth- and fourth-century BC epigraphical and literary documents pertaining to what we may call ‘ancient ecology’. Even though documents are not many, there is proof of laws governing cleanness and decorum of Greek cities’ public space. From the evidence it is possible to state that city institutions intervened on this matter only in few and ‘exceptional’ cases, with the aim of preventing that some particular areas of the city, which were of primary importance for the community life, got dirty. Citizens were subject to fines, if they threw in public spaces (i.e. streets) animal and human waste, or craftwork activities’. In particular, inscriptions from Athens an…