Search results for "RULE"
showing 10 items of 1403 documents
Construction of decision support system in business design based on integration of information technology
2016
In an increasingly competitive environment the successful functioning of any business requires continuous improvement of services, expanding the range of products and range of services, standardization, and implementation of new busines ideas, establishment and dissemination of innovative solutions on the market. The implementation of such measures were carried out in a well-developed business projects. Automating business processes often requires the organization of various programs, which creates a problem of integration. The paper attempts to organizations handling business processes through the integration of various software tools. One of the major component due implementing business p…
Joint Development of Novel Business Models
2006
Changing competitive environment forces companies to innovate and renew their business models towards a more value-adding and customer-centric direction. Often, a prerequisite for this is that the companies are willing to combine their capabilities by co-operating and creating long-term strategic networks with each other. The formation of networks is a cyclical learning process, along which the infrastructure and strategies emerge incrementally through mutual adjustment. We analyze such network formation process among three companies that are operating in separate but complementary industries. They are seeking to expand their service offering through the use of ICT. We reflect upon this dev…
Business Process Models and Information System Usability
2015
Abstract The paper describes the use of business process models for effective managing of information system execution processes and transparent representation of execution statuses. Contrary to traditional approaches where business process models are used only in the initial stages of information system development, the proposed approach suggests direct utilization of business process models during the use of information systems. Information system usability can be improved by using new means of representation, and business process models can serve as an efficient way to visualize execution processes in information systems.
The Content of Economic Partnership Agreements
2021
This chapter contains the second part of exemplary EPA critique related to the content of the treaties. All relevant economic aspects and clauses of the trade-in-goods agreements are critically examined, including the market access offer, quantitative restrictions, trade remedies, export duties and subsidies, national treatment and procurement, and rules of origin. The agreed and proposed clauses are submitted to scrutiny of whether the remaining policy space still allows sensible infant industry protection in Africa. The analysis concludes that some policy space is left for targeted developmental efforts by African governments but is made very difficult in the practical management of the n…
The Use of Rule-Based and QSPR Approaches in ADME Profiling: A Case Study on Caco-2 Permeability.
2013
During the early ADME profiling the development of simple, interpretable and reliable in silico tools is very important. In this study, rule-based and QSPR approaches were investigated using a large Caco-2 permeability database. Three permeability classes were determined: high (H), moderate (M) and low (L). The main physicochemical properties related with permeability were ranked as follows: Polar Surface Area (PSA)>Lipophilicity (logP/logD)>Molecular Weight (MW)>number of Hydrogen Bond donors and acceptors>Ionization State>number of Rotatable Bonds>number of Rings. The best rule, based on the combination of PSA-MW-logD (3PRule), was able to identify the H, M and L classes with accuracy of …
Psychological and physiological influences in chord progression including the prohibitions
2009
Harmony is one of three major elements in the music. Harmonics are the basic theory of composition. There are several kinds of prohibitions in relation to the chord progression in the rules of Harmonics. When composers compose music pieces, they pay attention not to contain these prohibitions. The prohibitions are empirically- defined with giving the musical expressions to melody processes by try and error. Even so, there are few studies that are quantitatively examined the perceptual effect of the prohibitions. Therefore, the authors have investigated the perceptual effects of the prohibition quantitatively. The present study deals with the psychological tests and the physiological measure…
Microbiological control of soil-borne phytopathogenic fungi with special emphasis on wilt-inducing Fusarium oxysporum
2009
Contents Summary 529 I. Biological control of plant diseases: state of the art 530 II. Main modes of action of biological control agents 530 III. The protective strains of F. oxysporum: an unexplored model 532 IV. Future directions for the study of the protective capacity of strains of F. oxysporum 539 V. How to make biological control successful in the field? 540 References 541 Summary Plant diseases induced by soil-borne plant pathogens are among the most difficult to control. In the absence of effective chemical control methods, there is renewed interest in biological control based on application of populations of antagonistic micro-organisms. In addition to Pseudomonas spp. a…
Cell Susceptibility to Baculovirus Transduction and Echovirus Infection Is Modified by Protein Kinase C Phosphorylation and Vimentin Organization
2013
ABSTRACT Some cell types are more susceptible to viral gene transfer or virus infection than others, irrespective of the number of viral receptors or virus binding efficacy on their surfaces. In order to characterize the cell-line-specific features contributing to efficient virus entry, we studied two cell lines (Ea.hy926 and MG-63) that are nearly nonpermissive to insect-specific baculovirus (BV) and the human enterovirus echovirus 1 (EV1) and compared their characteristics with those of a highly permissive (HepG2) cell line. All the cell lines contained high levels of viral receptors on their surfaces, and virus binding was shown to be efficient. However, in nonpermissive cells, BV and it…
Mutational analyses of YqjA, a Tvp38/DedA protein of E. coli
2015
AbstractMembrane proteins of the DedA/Tvp38 protein family are involved in membrane integrity and virulence of pathogenic organisms. However, the structure and exact function of any member of this large protein family are still unclear. In the present study we analyzed the functional and structural properties of a DedA homolog. Purified YqjA variants from Escherichia coli are detectable in different oligomeric states and specific homo-interaction of YqjA monomers in the membrane were confirmed by formation of a disulfide bond in the C-terminal transmembrane helix. Moreover, alanine scanning mutagenesis exhibited different interaction sites crucial for YqjA activity vs. dimer formation.
Tools for Pathogen Proteomics: Fishing with Biomimetic Nanosponges
2017
The identification of the major virulence factors that drive pathogenicity is critical for gaining insight into the underlying molecular mechanisms of diseases. Although genetic approaches combined with functional analyses have markedly increased the rate of virulence factor discovery, the divergence between genome and proteome can impair the identification of important markers, in particular, of those that act in concert or depend on specific environmental factors. Recently, membrane-coated nanomaterials mimicking source cells of interest have emerged as powerful tools that can be used for improved tumor targeting and as "nanotraps" to capture chemokines and bacterial toxins. In this issue…