Search results for "Radiation therapy"
showing 4 items of 504 documents
Rac1-Regulated Endothelial Radiation Response Stimulates Extravasation and Metastasis That Can Be Blocked by HMG-CoA Reductase Inhibitors
2011
Radiotherapy (RT) plays a key role in cancer treatment. Although the benefit of ionizing radiation (IR) is well established, some findings raise the possibility that irradiation of the primary tumor not only triggers a killing response but also increases the metastatic potential of surviving tumor cells. Here we addressed the question of whether irradiation of normal cells outside of the primary tumor augments metastasis by stimulating the extravasation of circulating tumor cells. We show that IR exposure of human endothelial cells (EC), tumor cells (TC) or both increases TC-EC adhesion in vitro. IR-stimulated TC-EC adhesion was blocked by the HMG-CoA reductase inhibitor lovastatin. Glycyrr…
THERP and HEART integrated methodology for human error assessment
2014
Medical errors are one of the leading causes of death and injury in radiation therapy administration as reported in the literature. This point out an overall deficiency in management allowing patient treatment in the absence of suitable quality assurance processes. Clinical records of major accidental exposure events in radiotherapy show that there is a combination of factors contributing to the accident such as deficient staff training, lack of independent checks, lack of quality control procedures, and absence of overall supervision. Another finding is that training generally addresses only normal situations and does not prepare radiotherapy staff for unusual situations, resulting in a la…
Management of Early Glottic Cancer Treated by CO2 Laser According to Surgical-Margin Status: A Systematic Review of the Literature
2021
Abstract Introduction Transoral laser microsurgery (TLM) is the treatment of choice for Tis-T2 squamous cell glottic carcinomas due to its advantages compared with open surgery and radiotherapy. However, the CO2 laser beam causes changes and damage on the specimens, making the histological assessment of resection margins, the gold standard for confirming radical tumor resection, sometimes difficult. Objective To assess the different ways to manage patients depending on the status of the histopathological margin according to recent studies to detect the most commonly shared therapeutic strategy. Data Synthesis We analyzed the literature available on the PubMed and Web of Science databases, i…
Towards a Guidance System to Aid in the Dosimetry Calculation of Intraoperative Electron Radiation Therapy
2015
In Intraoperative Electron Radiation Therapy (IOERT), the lack of specific planning tools limits its applicability, the need for accurate dosimetry estimation and application during the therapy being the most critical. Recently, some works have been presented that try to overcome some of the limitations for establishing planning tools, though still an accurate guidance system that tracks, in real-time, the applicator and the patient is needed. In these surgical environments, the acquisition of an accurate 3D shape of the patient’s tumor bed in real-time is of high interest, as current systems make use of a 3D model acquired before the treatment. In this paper, an optical-based system is pre…