Search results for "Radiolabelling"
showing 2 items of 2 documents
Iron oxides nanoparticles and titanate nanotubes dedicated to multimodal imaging and anticancer therapy
2013
The new implementations of nanoparticles in the medical field are one of the essential factors of the medical progress expected at the beginning of this XXIst century. Thus, the domain of the medical imaging is also affected by this technological evolution. This work consisted in developing theranostic probes with iron oxides nanoparticles (SPIO) and titanate nanotubes (TiONts) for multimodal imaging (magnetic/nuclear or magnetic/optical) and also possessing a therapeutic effect (hyperthermia/PDT or radiosensitization/PDT).The titanate nanotubes of this study have an average length of about 150 nm and were obtained by Kasuga's hydrothermal synthesis. These nanotubes present an outside diame…
Endothelialization of chitosan porous conduits via immobilization of a recombinant fibronectin fragment (rhFNIII7–10)
2013
Abstract The present study aimed to develop a pre-endothelialized chitosan (CH) porous hollowed scaffold for application in spinal cord regenerative therapies. CH conduits with different degrees of acetylation (DA; 4% and 15%) were prepared, characterized (microstructure, porosity and water uptake) and functionalized with a recombinant fragment of human fibronectin (rhFNIII 7–10 ). Immobilized rhFNIII 7–10 was characterized in terms of amount ( 125 I-radiolabelling), exposure of cell-binding domains (immunofluorescence) and ability to mediate endothelial cell (EC) adhesion and cytoskeletal rearrangement. Functionalized conduits revealed a linear increase in immobilized rhFNIII 7–10 with rhF…