Search results for "Radionuclide"

1st World Congress on Ga-68 and Peptide Receptor Radionuclide Therapy (PRRNT), June 23-26, 2011, Zentralklinik Bad Berka, Germany

2011

90Y radioembolization in the treatment of neuroendocrine neoplasms: Results of an international multicenter retrospective study.

2021

In neuroendocrine neoplasms (NEN), the presence of distant metastases has a severe impact on survival leading to a relevant decrease of the 5-year survival rate. Here, 90Y radioembolization (RE) might be an important treatment option, however, data to support clinical benefits for RE are scarce. Therefore, the purpose of this study was to analyze the use of RE in NEN patients with hepatic metastases in an international, multi-center retrospective analysis and assess the potential role of RE in a multimodal treatment concept. Methods: 297 angiographic evaluations in NEN patients prior to RE were analyzed. Baseline characteristics and parameters derived from imaging evaluation and RE were ana…

Total synthesis and evaluation of [18F]MHMZ.

2007

Radiochemical labeling of MDL 105725 using the secondary labeling precursor 2-[(18)F]fluoroethyltosylate ([(18)F]FETos) was carried out in yields of approximately 90% synthesizing [(18)F]MHMZ in a specific activity of approximately 50MBq/nmol with a starting activity of approximately 3GBq. Overall radiochemical yield including [(18)F]FETos synthon synthesis, [(18)F]fluoroalkylation and preparing the injectable [(18)F]MHMZ solution was 42% within a synthesis time of approximately 100 min. The novel compound showed excellent specific binding to the 5-HT(2A) receptor (K(i)=9.0 nM) in vitro and promising in vivo characteristics.

68Ge/68Ga Generators: Past, Present, and Future

2012

In 1964, first (68)Ge/(68)Ga radionuclide generators were described. Although the generator design was by far not adequate to our today's level of chemical, radiopharmaceutical and medical expectations, it perfectly met the needs of molecular imaging of this period. (68)Ga-EDTA as directly eluted from the generators entered the field of functional diagnosis, in particular for brain imaging. A new type of generators became commercially available in the first years of the 21st century. Generator eluates based on hydrochloric acid provided "cationic" (68)Ga instead of "inert" (68)Ga-complexes and opened new pathways of Me(III) based radiopharmaceutical chemistry. The impressive success of util…

Environmental Gamma Radiation Measurements on the Island of Pantelleria

1992

The population exposure to those living on the island of Pantelleria, Italy, was estimated by measuring the natural gamma background. Gamma spectra of natural rocks and measurements of absorbed dose in air were taken. A correlation was found between the mean gamma exposure rate and the mean values of natural radionuclide concentrations in the investigated rocks.

Geo-neutrino results with Borexino

2015

International audience; Borexino is a liquid scintillator detector primary designed to observe solar neutrinos. Due to its low background level as well as its position in a nuclear free country, Italy, Borexino is also sensitive to geo-neutrinos. Borexino is leading this interdisciplinary field of neutrino geoscience by studying electron antineutrinos which are emitted from the decay of radioactive isotopes present in the crust and the mantle of the Earth. With 2056 days of data taken between December 2007 and March 2015, Borexino observed 77 antineutrino candidates. If we assume a chondritic Th/U mass ratio of 3.9, the number of geo-neutrino events is found to be 23.7(+6.5) (-5.7)(stat) (+…

Dry deposition models for radionuclides dispersed in air: a new approach for deposition velocity evaluation schema

2017

In the framework of a National Research Program funded by the Italian Minister of Economic Development, the Department of Energy, Information Engineering and Mathematical Models (DEIM) of Palermo University and ENEA Research Centre of Bologna, Italy is performing several research activities to study physical models and mathematical approaches aimed at investigating dry deposition mechanisms of radioactive pollutants. On the basis of such studies, a new approach to evaluate the dry deposition velocity for particles is proposed. Comparisons with literature experimental data show that the proposed dry deposition scheme allows to capture the main phenomena involved in the dry deposition process…

Thorium-234 derived information on particle residence times and sediment deposition in shallow waters of the south-western Baltic Sea

2009

Abstract Activities of the naturally occurring, short-lived and highly particle-reactive radionuclide tracer 234 Th in the dissolved and particulate phase were measured at three shallow-water stations (maximum water depths: 15.6, 22.7 and 30.1 m) in Mecklenburg Bay (south-western Baltic Sea) to constrain the time scales of the dynamics and the depositional fate of particulate matter. Activities of particle-associated (> 0.4 μm) and total (particulate + dissolved) 234 Th were in the range of 0.08–0.11 dpm L − 1 and 0.11–0.20 dpm L − 1 , respectively. The activity ratio of total 234 Th and its long-lived and conservative parent nuclide 238 U was well below unity (range: 0.09–0.19) indicating …

Validating the use of caesium-137 measurements to estimate soil erosion rates in a small drainage basin in Calabria, Southern Italy

2001

Recent concern for problems of soil degradation and the offsite impacts of accelerated erosion has highlighted the need for improved methods of estimating rates and patterns of soil erosion by water. The use of environmental radionuclides, particularly caesium-137 (137Cs), as a means of estimating rates of soil erosion and deposition is attracting increasing attention and the approach has now been recognised as possessing several important advantages. However, one important uncertainty associated with the use of 137Cs measurements to estimate soil erosion rates is the need to employ a calibration relationship to convert the measured 137Cs inventory to an estimate of the erosion rate. Existi…

Validating erosion rate estimates provided by caesium-137 measurements for two small forested catchments in Calabria, southern Italy

2003

Increasing concern for problems of soil degradation and the off-site impacts of accelerated erosion has generated a need for improved methods of estimating rates and patterns of soil erosion by water. The use of environmental radionuclides, particularly 137 Cs, to estimate erosion rates has attracted increased attention and the approach has been shown to possess several important advantages. However, the use of 137 Cs measurements to estimate erosion rates introduces one important uncertainty, namely, the need to employ a conversion model or relationship to convert the measured reduction in the 137 Cs inventory to an estimate of the erosion rate. There have been few attempts to validate the…