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Metabolic and Vascular Effect of the Mediterranean Diet
2019
Several studies indicated how dietary patterns that were obtained from nutritional cluster analysis can predict disease risk or mortality. Low-grade chronic inflammation represents a background pathogenetic mechanism linking metabolic risk factors to increased risk of chronic degenerative diseases. A Mediterranean diet (MeDi) style has been reported as associated with a lower degree of inflammation biomarkers and with a protective role on cardiovascular and cerebrovascular events. There is heterogeneity in defining the MedDiet, and it can, owing to its complexity, be considered as an exposome with thousands of nutrients and phytochemicals. Recently, it has been reported a novel positive ass…
First-order linear differential equations whose data are complex random variables: Probabilistic solution and stability analysis via densities
2022
[EN] Random initial value problems to non-homogeneous first-order linear differential equations with complex coefficients are probabilistically solved by computing the first probability density of the solution. For the sake of generality, coefficients and initial condition are assumed to be absolutely continuous complex random variables with an arbitrary joint probability density function. The probability of stability, as well as the density of the equilibrium point, are explicitly determined. The Random Variable Transformation technique is extensively utilized to conduct the overall analysis. Several examples are included to illustrate all the theoretical findings.
Some properties of multi-degree-of-freedom potential systems and application to statistical equivalent non-linearization
2003
This paper presents some properties of two restricted classes of multi-degree-of-freedom potential systems subjected to Gaussian white-noise excitations. Specifically, potential systems which exhibit damping terms with energy-dependent polynomial form are referred to. In this context, first systems with coupled stiffness terms and damping terms depending on the total energy are investigated. Then, systems with uncoupled stiffness terms and damping terms depending on the total energy in each degree-of-freedom are considered. For these two classes, it is found that algebraic relations among the stationary statistical moments of the energy functions can be derived by applying standard tools of…
Isobaric Vapor−Liquid Equilibria for Ethyl Acetate + Ethanol + 1-Ethyl-3-methylimidazolium Trifluoromethanesulfonate at 100 kPa
2007
Isobaric vapor−liquid equilibria for the binary systems ethyl acetate + ethanol, ethyl acetate + 1-ethyl-3-methylimidazolium trifluoromethanesulfonate ([emim][triflate]), and ethanol + [emim][triflate] as well as the vapor−liquid equilibria for the ethyl acetate + ethanol + [emim][triflate] ternary system have been obtained at 100 kPa using a recirculating still. NRTL fitting parameters for the ethyl acetate + ethanol and ethanol + [emim][triflate] systems were calculated. The measured ternary data were correlated using the Mock electrolyte NRTL model, which reproduces reasonably well the experimental values. The results suggest that the addition of [emim][triflate] to the ethyl acetate + e…
Thermodynamic Analysis and Process Simulation of Ethanol Dehydration via Heterogeneous Azeotropic Distillation
2014
The heterogeneous azeotropic distillation process is widely used to separate nonideal binary mixtures into their constituent pure components. This method uses the addition of a third component, called an entrainer, to cause liquid–liquid phase separation over a broad range of compositions in the ternary phase diagram. Ethanol dehydration was used as a case study and diisopropyl ether and isobutyl alcohol were analyzed as possible entrainers in a heterogeneous azeotropic distillation. In this way, isobaric vapor–liquid–liquid equilibrium was measured for the ethanol + water + diisopropyl ether or + isobutyl alcohol ternary mixtures at 101.3 kPa. The data were correlated by the NRTL and UNIQU…
Genetic and phytochemical difference between some Indian and Italian plants of Whitania somnifera (L.) Dunal
2007
The geographical distribution of Withania somnifera (L.) Dunal is quite wide. However, in Italy. this species is very rare and grows spontaneously only in Sicily and in Sardinia. The PCR-RAPD technique has been utilized in this work to determine the genetic relationship among Sicilian, Sardinian and Indian samples and the HPLC analysis of whitaferin A was used as a marker to evaluate the phytochemical differences. The genetic difference between Indian and Sicilian plants of W. somnifera turned out to be smaller than that between Indian and Sardinian plants of this species. The phytochemical analysis as well showed that the Sardinian specimen strongly differed from the Indian and Sicilian on…
Modeling the Mechanical Behavior of the Breast Tissues Under Compression in Real Time
2017
This work presents a data-driven model to simulate the mechanical behavior of the breast tissues in real time. The aim of this model is to speed up some multimodal registration algorithms, as well as some image-guided interventions. Ten virtual breast phantoms were used in this work. Their deformation during a mammography was performed off-line using the finite element method. Three machine learning models were trained with the data from those simulations. Then, they were used to predict the deformation of the breast tissues. The models were a decision tree and two ensemble methods (extremely randomized trees and random forest). Four experiments were designed to assess the performance of th…
Effect of a prenatal lifestyle intervention on physical activity level in late pregnancy and the first year postpartum
2017
Background: Despite documented health benefits for mother and baby, physical activity (PA)-level tends to decline in pregnancy. Overweight/obese and physically inactive women are two selected groups at increased risk of pregnancy complications. Thus, efficient strategies to maintain or increase PA-level in pregnancy and the postpartum period, especially among these women, are warranted. This secondary analysis examined the effect of a prenatal lifestyle-intervention on PA-level in late pregnancy and the first year postpartum, with subanalysis on initially physically active versus inactive and normal-weight versus overweight/obese women. Method: The Norwegian Fit for Delivery (NFFD) randomiz…
Global collaborative networks on meta-analyses of randomized trials published in high impact factor medical journals: a social network analysis
2014
Abstract Background Research collaboration contributes to the advancement of knowledge by exploiting the results of scientific efforts more efficiently, but the global patterns of collaboration on meta-analysis are unknown. The purpose of this research was to describe and characterize the global collaborative patterns in meta-analyses of randomized trials published in high impact factor medical journals over the past three decades. Methods This was a cross-sectional, social network analysis. We searched PubMed for relevant meta-analyses of randomized trials published up to December 2012. We selected meta-analyses (including at least randomized trials as primary evidence source) published in…
An evidence based therapeutic approach to hereditary and acquired angioedema
2014
Purpose of review Hereditary angioedema (HAE) due to C1 esterase inhibitor (C1-INH) deficiency (HAE-C1-INH), HAE with normal C1-INH, and acquired angioedema due to C1-INH deficiency are rare but important diseases that can be associated with significant morbidity and mortality. Research into the pathogenesis of angioedema has expanded greatly and has led to new clinical trials with novel therapeutic agents and strategies. Recent findings Strategies for managing HAE-C1-INH are aimed at treating acute attacks or preventing attacks through the use of prophylactic treatment. Agents available in Europe for treating acute attacks include plasma-derived C1-INH concentrates, a bradykinin B2 recepto…