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showing 10 items of 3931 documents

LABA/LAMA fixed-dose combinations in patients with COPD: A systematic review

2018

Paola Rogliani,1 Luigino Calzetta,1 Fulvio Braido,2 Mario Cazzola,1 Enrico Clini,3 Girolamo Pelaia,4 Andrea Rossi,5 Nicola Scichilone,6 Fabiano Di Marco7 1Department of Experimental Medicine and Surgery, University of Rome Tor Vergata, Rome, Italy; 2Department of Internal Medicine, IRCCS San Martino Genoa University Hospital, Genoa, Italy; 3Department of Medical and Surgical Sciences, University of Modena and Reggio Emilia, Modena, Italy; 4Department of Medical and Surgical Sciences, Section of Respiratory Diseases, Magna Græcia University, Catanzaro, Italy; 5Pulmonary Unit, University of Verona, Verona, Italy; 6Department of Internal Medicine, University of Palermo, Palermo, Italy; 7…

ExacerbationReviewQuinoloneslaw.inventionPulmonary Disease Chronic Obstructivechemistry.chemical_compound0302 clinical medicineRandomized controlled trialsystematic reviewlaw030212 general & internal medicineCOPDLABA LAMA fixed-dose combination COPD systematic reviewbiologyHealth PolicyOlodaterolLAMAGeneral MedicineLamaRespiratory Function Testsfixed-dose combinationDrug CombinationsTreatment OutcomeIndanssystematic review.hormones hormone substitutes and hormone antagonistsmedicine.drugPulmonary and Respiratory Medicinemedicine.medical_specialtyFixed-dose combinationLABA; LAMA; fixed-dose combination; COPD; systematic reviewLABAMuscarinic AntagonistsSettore MED/10 - Malattie Dell'Apparato Respiratorio03 medical and health sciencesInternal medicinemedicineHumansCOPDAdverse effectAdrenergic beta-2 Receptor Agonistslcsh:RC705-779business.industryPublic Health Environmental and Occupational Healthlcsh:Diseases of the respiratory systemCOPD; LABA; LAMA; fixed-dose combination; systematic reviewmedicine.diseasebiology.organism_classificationGlycopyrrolate030228 respiratory systemchemistryDelayed-Action PreparationsIndacaterolbusiness
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Backwards Martingales and Exchangeability

2020

With many data acquisitions, such as telephone surveys, the order in which the data come does not matter. Mathematically, we say that a family of random variables is exchangeable if the joint distribution does not change under finite permutations. De Finetti’s structural theorem says that an infinite family of E-valued exchangeable random variables can be described by a two-stage experiment. At the first stage, a probability distribution Ξ on E is drawn at random. At the second stage, independent and identically distributed random variables with distribution Ξ are implemented.

Exchangeable random variablesDiscrete mathematicsIndependent and identically distributed random variablesDistribution (number theory)Conditional independenceJoint probability distributionProbability distributionConditional probability distributionRandom variableMathematics
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Forward and backward diffusion approximations for haploid exchangeable population models

2001

Abstract The class of haploid population models with non-overlapping generations and fixed population size N is considered such that the family sizes ν1,…,νN within a generation are exchangeable random variables. A criterion for weak convergence in the Skorohod sense is established for a properly time- and space-scaled process counting the number of descendants forward in time. The generator A of the limit process X is constructed using the joint moments of the offspring variables ν1,…,νN. In particular, the Wright–Fisher diffusion with generator Af(x)= 1 2 x(1−x)f″(x) appears in the limit as the population size N tends to infinity if and only if the condition lim N→∞ E((ν 1 −1) 3 )/(N Var …

Exchangeable random variablesStatistics and ProbabilityDualityPopulation geneticsCoalescent theoryDiffusion approximationModelling and SimulationQuantitative Biology::Populations and EvolutionNeutralityWright–Fisher diffusionHille–Yosida theoremWeak convergenceMathematicsWeak convergenceApplied MathematicsMathematical analysisHeavy traffic approximationCommutative diagramHille–Yosida theoremPopulation modelDiffusion processModeling and SimulationAncestorsDescendantsExchangeabilityCoalescentStochastic Processes and their Applications
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Is it possible to change of the duration of consolidation period in the distraction osteogenesis with the repetition of extracorporeal shock waves?

2016

Background In this study we examined the effects of two different repeated Extracorporeal Shock Waves (ESW) on the consolidation period of the distraction osteogenesis (DO) of the rabbit mandible using stereological, radiological and immunohistochemical methods. Material and Methods DO was performed unilaterally in the mandible of 18 New Zealand rabbits (six months old, weighing between 2.5-3 kg). In the consolidation period, rabbits were divided into three groups randomly after the distraction period. The distraction zone of the mandible was received no treatment as controls (E0*2). Group 2 (E 500*2) received ESWT (twice 500 impulses at 14 kV and 0.19 mJ/mm2 energy) in the first and fourth…

Extracorporeal Shockwave TherapyDistraction osteogenesisTime FactorsBone densitymedicine.medical_treatmentStereologyOsteogenesis DistractionStereologyRabbitMandibleNew Zealand rabbitsurgeryangiogenesisRandom Allocation0302 clinical medicinetime factorMedicineanimalconnective tissueBone mineralOrthodonticsFracture Healingbone density:CIENCIAS MÉDICAS [UNESCO]stereometry030220 oncology & carcinogenesisExtracorporeal shockwave therapyimmunohistochemistryUNESCO::CIENCIAS MÉDICASDistraction osteogenesisRabbitsmedicine.symptomOral Surgerymedicine.medical_specialtyshock waveLeporidaerabbitBone healingrandomizationExtracorporeal03 medical and health sciencesAnimalshumanproceduresGeneral Dentistrynonhumanbusiness.industryOssificationResearchcontrol group030206 dentistryhuman tissueextracorporeal shock wavesSurgeryossificationOtorhinolaryngologyExtracorporeal shock wavesshock wave therapystereologybusiness
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A probabilistic estimation and prediction technique for dynamic continuous social science models: The evolution of the attitude of the Basque Country…

2015

In this paper, a computational technique to deal with uncertainty in dynamic continuous models in Social Sciences is presented.Considering data from surveys,the method consists of determining the probability distribution of the survey output and this allows to sample data and fit the model to the sampled data using a goodness-of-fit criterion based the χ2-test. Taking the fitted parameters that were not rejected by the χ2-test, substituting them into the model and computing their outputs, 95% confidence intervals in each time instant capturing the uncertainty of the survey data (probabilistic estimation) is built. Using the same set of obtained model parameters, a prediction over …

FOS: Computer and information sciencesAttitude dynamicsProbabilistic predictionComputer sciencePopulationDivergence-from-randomness modelSample (statistics)computer.software_genreMachine Learning (cs.LG)Probabilistic estimationSocial scienceeducationProbabilistic relevance modeleducation.field_of_studyApplied MathematicsProbabilistic logicConfidence intervalComputer Science - LearningComputational MathematicsSocial dynamic modelsProbability distributionSurvey data collectionData miningMATEMATICA APLICADAcomputerApplied Mathematics and Computation
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Retrieval of Case 2 Water Quality Parameters with Machine Learning

2018

Water quality parameters are derived applying several machine learning regression methods on the Case2eXtreme dataset (C2X). The used data are based on Hydrolight in-water radiative transfer simulations at Sentinel-3 OLCI wavebands, and the application is done exclusively for absorbing waters with high concentrations of coloured dissolved organic matter (CDOM). The regression approaches are: regularized linear, random forest, Kernel ridge, Gaussian process and support vector regressors. The validation is made with and an independent simulation dataset. A comparison with the OLCI Neural Network Swarm (ONSS) is made as well. The best approached is applied to a sample scene and compared with t…

FOS: Computer and information sciencesComputer Science - Machine Learning010504 meteorology & atmospheric sciences0211 other engineering and technologiesFOS: Physical sciences02 engineering and technologyMachine learningcomputer.software_genre01 natural sciencesData modelingMachine Learning (cs.LG)Physics - Geophysicssymbols.namesakeRadiative transferGaussian process021101 geological & geomatics engineering0105 earth and related environmental sciencesMathematicsArtificial neural networkbusiness.industry6. Clean waterRandom forestGeophysics (physics.geo-ph)Support vector machineColored dissolved organic matterKernel (statistics)Physics - Data Analysis Statistics and ProbabilitysymbolsArtificial intelligencebusinesscomputerData Analysis Statistics and Probability (physics.data-an)
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Retrieval of coloured dissolved organic matter with machine learning methods

2017

The coloured dissolved organic matter (CDOM) concentration is the standard measure of humic substance in natural waters. CDOM measurements by remote sensing is calculated using the absorption coefficient (a) at a certain wavelength (e.g. 440nm). This paper presents a comparison of four machine learning methods for the retrieval of CDOM from remote sensing signals: regularized linear regression (RLR), random forest (RF), kernel ridge regression (KRR) and Gaussian process regression (GPR). Results are compared with the established polynomial regression algorithms. RLR is revealed as the simplest and most efficient method, followed closely by its nonlinear counterpart KRR.

FOS: Computer and information sciencesComputer Science - Machine Learning010504 meteorology & atmospheric sciences0211 other engineering and technologiesFOS: Physical sciences02 engineering and technologyMachine learningcomputer.software_genre01 natural sciencesMachine Learning (cs.LG)Physics - GeophysicsKrigingDissolved organic carbonLinear regression021101 geological & geomatics engineering0105 earth and related environmental sciencesMathematicsPolynomial regressionbusiness.industry6. Clean waterGeophysics (physics.geo-ph)Random forestNonlinear systemColored dissolved organic matterKernel (statistics)Artificial intelligencebusinesscomputer
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Using the Tsetlin Machine to Learn Human-Interpretable Rules for High-Accuracy Text Categorization With Medical Applications

2019

Medical applications challenge today's text categorization techniques by demanding both high accuracy and ease-of-interpretation. Although deep learning has provided a leap ahead in accuracy, this leap comes at the sacrifice of interpretability. To address this accuracy-interpretability challenge, we here introduce, for the first time, a text categorization approach that leverages the recently introduced Tsetlin Machine. In all brevity, we represent the terms of a text as propositional variables. From these, we capture categories using simple propositional formulae, such as: if "rash" and "reaction" and "penicillin" then Allergy. The Tsetlin Machine learns these formulae from a labelled tex…

FOS: Computer and information sciencesComputer Science - Machine LearningGeneral Computer ScienceComputer sciencetext categorizationNatural language understandingDecision treeMachine Learning (stat.ML)02 engineering and technologyVDP::Teknologi: 500::Informasjons- og kommunikasjonsteknologi: 550::Annen informasjonsteknologi: 559Machine learningcomputer.software_genresupervised learningMachine Learning (cs.LG)Naive Bayes classifierText miningStatistics - Machine Learning0202 electrical engineering electronic engineering information engineeringGeneral Materials ScienceTsetlin machinehealth informaticsInterpretabilityPropositional variableClassification algorithmsArtificial neural networkbusiness.industryDeep learning020208 electrical & electronic engineeringGeneral EngineeringRandom forestSupport vector machinemachine learningCategorization020201 artificial intelligence & image processingArtificial intelligencelcsh:Electrical engineering. Electronics. Nuclear engineeringbusinessPrecision and recallcomputerlcsh:TK1-9971
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Kernel methods and their derivatives: Concept and perspectives for the earth system sciences.

2020

Kernel methods are powerful machine learning techniques which implement generic non-linear functions to solve complex tasks in a simple way. They Have a solid mathematical background and exhibit excellent performance in practice. However, kernel machines are still considered black-box models as the feature mapping is not directly accessible and difficult to interpret.The aim of this work is to show that it is indeed possible to interpret the functions learned by various kernel methods is intuitive despite their complexity. Specifically, we show that derivatives of these functions have a simple mathematical formulation, are easy to compute, and can be applied to many different problems. We n…

FOS: Computer and information sciencesComputer Science - Machine LearningSupport Vector MachineTheoretical computer scienceComputer scienceEntropyKernel FunctionsNormal Distribution0211 other engineering and technologies02 engineering and technologyMachine Learning (cs.LG)Machine LearningStatistics - Machine LearningSimple (abstract algebra)0202 electrical engineering electronic engineering information engineeringOperator TheoryData ManagementMultidisciplinaryGeographyApplied MathematicsSimulation and ModelingQRDensity estimationKernel methodKernel (statistics)Physical SciencessymbolsMedicine020201 artificial intelligence & image processingAlgorithmsResearch ArticleComputer and Information SciencesScienceMachine Learning (stat.ML)Research and Analysis MethodsKernel MethodsKernel (linear algebra)symbols.namesakeArtificial IntelligenceSupport Vector MachinesHumansEntropy (information theory)Computer SimulationGaussian process021101 geological & geomatics engineeringData VisualizationCorrectionRandom VariablesFunction (mathematics)Probability TheorySupport vector machineAlgebraPhysical GeographyLinear AlgebraEarth SciencesEigenvectorsRandom variableMathematicsEarth SystemsPLoS ONE
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A Two-Stage Reconstruction of Microstructures with Arbitrarily Shaped Inclusions

2020

The main goal of our research is to develop an effective method with a wide range of applications for the statistical reconstruction of heterogeneous microstructures with compact inclusions of any shape, such as highly irregular grains. The devised approach uses multi-scale extended entropic descriptors (ED) that quantify the degree of spatial non-uniformity of configurations of finite-sized objects. This technique is an innovative development of previously elaborated entropy methods for statistical reconstruction. Here, we discuss the two-dimensional case, but this method can be generalized into three dimensions. At the first stage, the developed procedure creates a set of black synthetic …

FOS: Computer and information sciencesComputer science02 engineering and technologylcsh:Technology01 natural sciencesArticleComputational Engineering Finance and Science (cs.CE)0103 physical sciencesCluster (physics)Effective methodGeneral Materials ScienceComputer Science - Computational Engineering Finance and Sciencelcsh:Microscopy010306 general physicslcsh:QC120-168.85lcsh:QH201-278.5Pixellcsh:Tmulti-scale entropic descriptorsrandom heterogeneous materials021001 nanoscience & nanotechnologyMicrostructureStandard techniqueCement pastetwo-stage reconstructionlcsh:TA1-2040simulated annealing for clustersSimulated annealinglcsh:Descriptive and experimental mechanicslcsh:Electrical engineering. Electronics. Nuclear engineeringlcsh:Engineering (General). Civil engineering (General)0210 nano-technologylcsh:TK1-9971AlgorithmMaterials
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