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showing 10 items of 3931 documents
Root Canal Morphology and Configuration of the Mandibular Canine: A Systematic Review
2021
The aim of this study was to systematically review the root canal morphology and configuration (RCC) of mandibular canines (MaCa). The review was registered in the PROSPERO database (ID-272297) and it was carried out following the PRISMA guidelines. Three electronic databases (MEDLINE via PubMed, Embase, Scopus) were searched. Randomized controlled trials, cross-sectional, cohort, comparative, evaluation and validation studies have been included. The anatomical quality assessment (AQUA) tool was used for a quality assessment of the anatomical studies. Of 910 studies retrieved from the systematic search, 28 studies investigating RCCs were included. Most MaCa were single-rooted (87.9–100%), w…
Charting a Roadmap for Heart Failure Biomarker Studies
2013
Heart failure is a syndrome with a pathophysiological basis that can be traced to dysfunction in several interconnected molecular pathways. Identification of biomarkers of heart failure that allow measurement of the disease on a molecular level has resulted in enthusiasm for their use in prognostication and selection of appropriate therapies. However, despite considerable amounts of information available on numerous biomarkers, inconsistent research methodologies and lack of clinical correlations have made bench-to-bedside translations rare and left the literature with countless publications of varied quality. There is a need for a systematic and collaborative approach aimed at definitively…
Efficacy and safety of combined neprilysin and RAS inhibition in heart failure: Let's leave the doubts behind
2020
Helicobacter pylori - diagnostika izmantojot 13C urīnvielas elptestu un seroloģijas testu: rezultātu salīdzināšana
2017
Ievads. 2012.gada veiktajā pētījumā tika iegūti dati, ka Latvijā Helicobacter Pylori (HP) izplatība pieaugušo populācijā ir augstā līmenī – 79.21%. Prezentētajā pētījumā tika analizēta HP infekcijas izplatība saistībā ar sociāli-demogrāfiskiem faktoriem - dalībnieku izglītības līmeni, nodarbinātību, vidējiem ienākumiem, ģimenes stāvokli, smēķēšanas paradumiem Latvijas iedzīvotājiem. Pētījuma mērķis. HP testu, kuri veikti izmantojot 13C urīnvielas elptestu un seroloģijas testu Daudzcentru randomizēts pētījums kuņģa vēža izraisītās mirstības samazināšanai (GISTAR) pētījuma ietvarā, rezultātu salīdzināšana saistībā ar sociāli-demogrāfiskiem faktoriem. Materiāli un metodes. Darbs ir šķērsgriezu…
Blood Congestion Can Be Rescued by Hemodilution in a Random-Pattern Skin Flap
2017
Interferon alfa for chronic hepatitis B infection: Increased efficacy of prolonged treatment
1999
Interferon alfa (IFN-alpha) is the primary treatment for chronic hepatitis B. The standard duration of IFN-alpha therapy is considered 16 weeks; however, the optimal treatment length is still poorly defined. We evaluated the efficacy and acceptability of prolonged IFN-alpha treatment in patients with chronic hepatitis B. To investigate whether treatment prolongation could enhance the rate of hepatitis B e antigen (HBeAg) seroconversion, we conducted a prospective, controlled, multicenter trial in which all patients were treated with a standard regimen of 10 million units IFN-alpha 3 times per week over 16 weeks. Patients who were still HBeAg-positive after 16 weeks of therapy were randomize…
EFFICACY AND SAFETY OF OZONE THERAPY FOR PATIENTS WITH CHRONIC HEPATITIS B: A MULTICENTER, RANDOMIZED CLINICAL TRIAL
2018
Background. Ozone therapy has a long history. Some studies proved that ozone therapy was useful in treatment of virus hepatitis. Objective: To evaluate the efficacy and safety of new medical ozone therapy system for the treatment of chronic hepatitis B. Method. One hundred eighty-nine patients with chronic hepatitis B were included in this open-label, phase 3 study, and randomly assigned to receive ozone autohemotherapy with experimental ozone generator TianYi (group 1) or with ozone generator Humares (group 2) or oral diammonium glycyrrhizinate capsules (group 3) in a 1:1:1 ratio for 12 weeks. The primary efficacy end point was sera HBV DNA level of less than 1×103 IU/ml or having a more t…
Imaging-guided interventions modulating portal venous flow: Evidence and controversies
2021
Portal hypertension is defined by an increase in the portosystemic venous gradient. In most cases, increased resistance to portal blood flow is the initial cause of elevated portal pressure. More than 90% of cases of portal hypertension are estimated to be due to advanced chronic liver disease or cirrhosis. Transjugular intrahepatic portosystemic shunts, a non-pharmacological treatment for portal hypertension, involve the placement of a stent between the portal vein and the hepatic vein or inferior vena cava which helps bypass hepatic resistance. Portal hypertension may also be a result of extrahepatic portal vein thrombosis or compression. In these cases, percutaneous portal vein recanalis…
Computer-aided detection of cerebral microbleeds in susceptibility-weighted imaging.
2014
Susceptibility-weighted imaging (SWI) is recognized as the preferred MRI technique for visualizing cerebral vasculature and related pathologies such as cerebral microbleeds (CMBs). Manual identification of CMBs is time-consuming, has limited reliability and reproducibility, and is prone to misinterpretation. In this paper, a novel computer-aided microbleed detection technique based on machine learning is presented: First, spherical-like objects (potential CMB candidates) with their corresponding bounding boxes were detected using a novel multi-scale Laplacian of Gaussian technique. A set of robust 3-dimensional Radon- and Hessian-based shape descriptors within each bounding box were then ex…
Avoiding Boundary Effects in Wang-Landau Sampling
2003
A simple modification of the ``Wang-Landau sampling'' algorithm removes the systematic error that occurs at the boundary of the range of energy over which the random walk takes place in the original algorithm.