Search results for "Random"
showing 10 items of 3931 documents
A randomized clinical trial to evaluate the plaque removal efficacy of an oscillating-rotating toothbrush versus a sonic toothbrush in orthodontic pa…
2018
ABSTRACT Objective: To compare the plaque removal efficacy of an oscillating-rotating electric toothbrush with an orthodontic brush head versus a sonic toothbrush in adolescent patients with fixed orthodontic appliances. Materials and Methods: This was a randomized, examiner-blind, replicate single-use, two-treatment, four-period, crossover study with a washout period between visits of approximately 24 hours. Forty-four adolescent patients with fixed orthodontic appliances in both arches were randomized based on a computer-generated randomization schedule to one of four toothbrush treatment sequences. The primary outcome was plaque score change from baseline, measured using digital plaque i…
Using Topic Modeling Methods for Short-Text Data: A Comparative Analysis
2020
With the growth of online social network platforms and applications, large amounts of textual user-generated content are created daily in the form of comments, reviews, and short-text messages. As a result, users often find it challenging to discover useful information or more on the topic being discussed from such content. Machine learning and natural language processing algorithms are used to analyze the massive amount of textual social media data available online, including topic modeling techniques that have gained popularity in recent years. This paper investigates the topic modeling subject and its common application areas, methods, and tools. Also, we examine and compare five frequen…
The Efficacy and Safety of Topiramate in the Prevention of Pediatric Migraine: An Update Meta-Analysis
2020
Background: Migraine is the most common acute primary headache in children and adolescents. In 2014, topiramate became the first preventive drug for migraine, approved by the Food and Drug Administration (FDA) for adolescents. This meta-analysis was aimed to evaluate the efficacy and safety of topiramate in the prevention of pediatric migraine.Methods: We searched the PubMed, EMBASE, Cochrane Library, and Chinese National Knowledge Infrastructure (CNKI) databases up to June 2019 for eligible randomized controlled trials (RCTs). The primary outcomes were mean migraine days per month, ≥50% reduction rate, and Pediatric Migraine Disability Assessment Scale (PedMIDAS) scores. RevMan5.3 software…
Randomized trial of a single, double and triple dose of 10 mg/kg of a human formulation of triclabendazole in patients with fascioliasis.
2004
1. A study performed > 10 years ago and case reports published recently suggest that triclabendazole is effective for the treatment of patients with fascioliasis. 2. To confirm the efficacy of a human formulation of triclabendazole, we enrolled 165 patients into the present study and divided the subjects into two groups: (i) those who had fascioliasis, as evidenced by the presence of ova in their stools; and (ii) patients with clinical and laboratory data suggesting fascioliasis. 3. Patients were randomly allocated to receive 10 mg/kg, p.o., triclabendazole for 1, 2 or 3 days (single-, double- and triple-dose groups, respectively). Medical history and physical and laboratory examinations we…
Feature Selection for Ensembles of Simple Bayesian Classifiers
2002
A popular method for creating an accurate classifier from a set of training data is to train several classifiers, and then to combine their predictions. The ensembles of simple Bayesian classifiers have traditionally not been a focus of research. However, the simple Bayesian classifier has much broader applicability than previously thought. Besides its high classification accuracy, it also has advantages in terms of simplicity, learning speed, classification speed, storage space, and incrementality. One way to generate an ensemble of simple Bayesian classifiers is to use different feature subsets as in the random subspace method. In this paper we present a technique for building ensembles o…
Ensemble Feature Selection Based on Contextual Merit and Correlation Heuristics
2001
Recent research has proven the benefits of using ensembles of classifiers for classification problems. Ensembles of diverse and accurate base classifiers are constructed by machine learning methods manipulating the training sets. One way to manipulate the training set is to use feature selection heuristics generating the base classifiers. In this paper we examine two of them: correlation-based and contextual merit -based heuristics. Both rely on quite similar assumptions concerning heterogeneous classification problems. Experiments are considered on several data sets from UCI Repository. We construct fixed number of base classifiers over selected feature subsets and refine the ensemble iter…
Blood Component Therapy and Coagulopathy in Trauma: A Systematic Review of the Literature from the Trauma Update Group
2016
Background Traumatic coagulopathy is thought to increase mortality and its treatment to reduce preventable deaths. However, there is still uncertainty in this field, and available literature results may have been overestimated. Methods We searched the MEDLINE database using the PubMed platform. We formulated four queries investigating the prognostic weight of traumatic coagulopathy defined according to conventional laboratory testing, and the effectiveness in reducing mortality of three different treatments aimed at contrasting coagulopathy (high fresh frozen plasma/packed red blood cells ratios, fibrinogen, and tranexamic acid administration). Randomized controlled trials were selected alo…
The mediating role of emotion regulation in transdiagnostic cognitive behavioural therapy for emotional disorders in primary care: Secondary analyses…
2022
Background: Emotional disorders are highly prevalent in primary care. Transdiagnostic cognitive behavior therapy (TD-CBT) is a promising treatment of emotional disorders. In this study, we evaluated several emotion regulation strategies as potential mediators of treatment outcomes in a clinical sample of primary care. Methods: A total of 1061 primary care patients were included in a randomized clinical trial comparing treatment- as-usual (TAU) to TD-CBT+TAU. Of these, 631 (TAU=316; TD-CBT+TAU=315) completed the full treatment and all pre- and post-treatment scales to assess symptoms (anxiety, depression, somatization), emotion regulation strategies (worry, rumination, negative metacognition…
Efficacy and cost-effectiveness of guided and unguided internet- and mobile-based indicated transdiagnostic prevention of depression and anxiety (ICa…
2019
Background Depression and anxiety are highly prevalent and often co-occur. Several studies indicate the potential of disorder-specific psychological interventions for the prevention of each of these disorders. To treat comorbidity, transdiagnostic treatment concepts seem to be a promising approach, however, evidence for transdiagnostic concepts of prevention remains inconclusive. Internet- and mobile-based interventions (IMIs) may be an effective means to deliver psychological interventions on a large scale for the prevention of common mental disorders (CMDs) such as depression and anxiety. IMIs have been shown to be effective in treating CMDs, e.g. in reducing symptoms of depression and an…
Clinico-Biomechanical Issues and Dynamic Stabilization When Considering Stem Cell Treatment for Degenerative Disc Disease
2013
After reading the article published in Transplantation (1), scientists are to be congratulatedVespecially with the clinical results as published. Looking for alternatives to avoid fusion is part of function-preserving spine care, as it should be the last option to be undertaken while keeping the debate open (2, 3). Nevertheless, we would like to point out some questions that arise from a clinical point of view from our daily surgical practice. First, several clinical presentations and procedures are compared without taking into account that they are different treatments applied for different disc disease situations (discectomy is performed for disc herniation with radicular symptoms, disc p…