Search results for "Randomized Controlled Trial"

showing 10 items of 2199 documents

Pain Neuroscience Education and Physical Therapeutic Exercise for Patients with Chronic Spinal Pain in Spanish Physiotherapy Primary Care: A Pragmati…

2020

Producción Científica

:Health Care::Health Services Administration::Patient Care Management::Delivery of Health Care [Medical Subject Headings]lcsh:MedicineChronic painEnsayo clínico controlado aleatoriolaw.invention:Phenomena and Processes::Musculoskeletal and Neural Physiological Phenomena::Nervous System Physiological Phenomena::Central Nervous System Sensitization [Medical Subject Headings]0302 clinical medicineRandomized controlled triallawphysical exerciseNeuroscience educationHealth care:Phenomena and Processes::Musculoskeletal and Neural Physiological Phenomena::Musculoskeletal Physiological Phenomena::Musculoskeletal Physiological Processes::Movement::Motor Activity [Medical Subject Headings]030212 general & internal medicine:Health Care::Population Characteristics::Health::Mental Health [Medical Subject Headings]education.field_of_study:Diseases::Pathological Conditions Signs and Symptoms::Signs and Symptoms::Neurologic Manifestations::Pain::Chronic Pain [Medical Subject Headings]Chronic pain:Phenomena and Processes::Musculoskeletal and Neural Physiological Phenomena::Nervous System Physiological Phenomena::Nervous System Physiological Processes::Sensation::Pain::Pain Threshold [Medical Subject Headings]General MedicinePrimary care:Psychiatry and Psychology::Behavior and Behavior Mechanisms::Behavior::Personal Satisfaction [Medical Subject Headings]Ejercicio físico:Health Care::Health Services Administration::Patient Care Management::Comprehensive Health Care::Primary Health Care [Medical Subject Headings]Randomized controlled trialchronic painchronic spinal painmedicine.medical_specialty:Analytical Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Methods::Research Design::Control Groups [Medical Subject Headings]PopulationChronic spinal painPhysical exerciseArticleEducación neurocientífica03 medical and health sciencesprimary careQuality of life (healthcare)medicine:Humanities::Humanities::Philosophy::Life::Quality of Life [Medical Subject Headings]educationpain neuroscience educationPain neuroscience educationbusiness.industry:Diseases::Musculoskeletal Diseases::Muscular Diseases::Musculoskeletal Pain [Medical Subject Headings]Public healthlcsh:RPhysical exerciseDolor crónicoAtención primariamedicine.diseaseClinical trialrandomized controlled trialPhysical therapy:Analytical Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Physical Examination::Neurologic Examination::Pain Measurement [Medical Subject Headings]businessNeuroscience030217 neurology & neurosurgeryJournal of Clinical Medicine
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Efficacy of an internet-based psychological intervention for problem gambling and gambling disorder: study protocol for a randomized controlled trial

2021

Gambling Disorder is a prevalent non-substance use disorder, which contrasts with the low number of people requesting treatment. Information and Communication Technologies (ICT) could help to enhance the dissemination of evidence-based treatments and considerably reduce the costs. The current study seeks to assess the efficacy of an online psychological intervention for people suffering from gambling problems in Spain. The proposed study will be a two-arm, parallel-group, randomized controlled trial. A total of 134 participants (problem and pathological gamblers) will be randomly allocated to a waiting list control group (N = 67) or an intervention group (N = 67). The intervention program i…

A ActionDGOJ Directorate General for the Regulation of GamblingCIDI Composite International Diagnostic InterviewPA Positive AffectSPIRIT Standard Protocol Items Recommendations for Interventional TrialsefficacyPsychological interventionMotivational interviewingGE Gambling ExpectanciesDSM-IV Diagnostic and Statistical Manual of Mental Disorders Fourth EditionOASIS The Overall Anxiety Severity and Impairment Scalelaw.inventionDERS Difficulties in Emotion Regulation ScaleRandomized controlled triallawPANAS The Positive and Negative Affect SchedulePsychologyRCT Randomized Controlled TrialUPPS-P The Short UPPS-P Impulsivity ScaleICD-10 International Statistical Classification of Diseases and Related Health Problems 10th RevisionCognitionT58.5-58.64GRCS-S Gambling-Related Cognitions ScalePC Predictive ControlBF1-990EDBs Emotion Driven BehavioursC ContemplationGSEQ Gambling Self-Efficacy QuestionnaireDSM-5 Diagnostic and Statistical Manual of Mental Disorders Fifth EditionAnxietyAddicció a Internetmedicine.symptomMI Motivational InterviewingPsychologyJocs per ordinadorM Maintenancemedicine.medical_specialtyemotion regulationG-SAS The Gambling Symptom Assessment ScaleEMA Ecological Momentary AssessmentODSIS The Overall Depression Severity and Impairment ScaleEfficacyWL Waiting ListIC Illusion of ControlIB Interpretative BiasMFS Monitoring Feedback and SupportCBTHealth InformaticsInformation technologyCBT Cognitive Behavioral TherapyImpulsivityCONSORT-EHEALTH Consolidated Standards of Reporting Trials of Electronic and Mobile Health Applications and Online TelehealthISG Perceived Inability to Stop GamblingQuality of life (healthcare)URICA The University of Rhode Island Change Assessment ScaleIntervention (counseling)medicineGD Gambling DisorderSCID-P The Structured Clinical InterviewPsychiatryQLI Quality Life IndexInternetEmotion regulationFull length ArticleSUS System Usability ScalegamblingEMI Ecological Momentary InterventionMINI Mini International Neuropsychiatric InterviewGI Gambling history interview and current gambling situation and related variables assessmentNA Negative AffectGamblingNODS NORC DSM-IV Screen for Gambling ProblemsPFIs Personal Feedback InterventionsDSM-III-R Diagnostic and Statistical Manual of Mental Disorders 3rd Edition RevisedHADS Hospital Anxiety Depression ScaleinternetP Precontemplation
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Importance of proper conduct of clinical trials

2021

AFRICAclinical trialsModels StatisticalActuarial sciencebusiness.industryMEDICINEinferential statisticsEvidence-based medicinerandomised controlled trialsBayesian statisticsBayesian statisticBayesian statisticsClinical trialAnesthesiology and Pain MedicineResearch DesignData Interpretation StatisticalCausal inferenceStatistical inferenceHumansMedicinecausal inferencebusinessevidence-based medicineRandomized Controlled Trials as Topic
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Do ventilatory parameters influence outcome in patients with severe acute respiratory infection? Secondary analysis of an international, multicentre1…

2021

Purpose: To investigate the possible association between ventilatory settings on the first day of invasive mechanical ventilation (IMV) and mortality in patients admitted to the intensive care unit (ICU) with severe acute respiratory infection (SARI). Materials and methods: In this pre-planned sub-study of a prospective, multicentre observational study, 441 patients with SARI who received controlled IMV during the ICU stay were included in the analysis. Results: ICU and hospital mortality rates were 23.1 and 28.1%, respectively. In multivariable analysis, tidal volume and respiratory rate on the first day of IMV were not associated with an increased risk of death; however, higher driving pr…

ARDSSoins intensifs réanimationmedicine.medical_treatmentAirway pressuresPEEP positive end-expiratory pressureCritical Care and Intensive Care Medicinelaw.inventionHypoxemiaCohort StudiesPositive-Pressure RespirationMechanical ventilationSARI severe acute respiratory infectionlawHospital MortalityProspective StudiesIQR interquartile rangesProspective cohort studyRCT randomized controlled trialTidal volumeSOFA Sequential Organ Failure AssessmentSAPS Simplified Acute Physiology ScoreIntensive care unitVCV volume-controlled ventilationHIV human immunodeficiency virusIntensive Care UnitsIC GLOSSARI Intensive Care Global Study on Severe Acute Respiratory Infectionmedicine.symptomCohort studyLOS length of staymedicine.medical_specialtyVt tidal volumeCOPD Chronic obstructive pulmonary diseaseNYHA New York Heart Association.PCV pressure-controlled ventilationArticleInternal medicineICU Intensive Care UnitSIMV Synchronized intermittent mandatory ventilationmedicineTidal VolumeHumansDP driving pressurePEEPARDS acute respiratory distress syndromeMechanical ventilationbusiness.industryOdds ratioPneumoniaPlateau pressuremedicine.diseaseRespiration ArtificialVILI ventilator induced lung injuryCI confidence intervalOR odds ratioIMV invasive mechanical ventilationCPAP continuous positive airway pressureARDSbusinessSD standard deviationECMO extracorporeal membrane oxygenationPBW predicted body weightPplat plateau pressure
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A new approach to ticagrelor-based de-escalation of antiplatelet therapy after acute coronary syndrome. A rationale for a randomized, double-blind, p…

2021

The risk of ischemic events gradually decreases after acute coronary syndrome (ACS), reaching a stable level after 1 month, while the risk of bleeding remains steady during the whole period of dual antiplatelet treatment (DAPT). Several de-escalation strategies of antiplatelet treatment aiming to enhance safety of DAPT without depriving it of its efficacy have been evaluated so far. We hypothesized that reduction of the ticagrelor maintenance dose 1 month after ACS and its continuation until 12 months after ACS may improve adherence to antiplatelet treatment due to better tolerability compared with the standard dose of ticagrelor. Moreover, improved safety of treatment and preserved anti-is…

Acute coronary syndromemedicine.medical_specialtyELECTRA-SIRIO 2TicagrelorClinical CardiologyPlaceboantiplatelet therapylaw.inventionacute coronary syndrometicagrelorClinical studyPercutaneous Coronary InterventionRandomized controlled triallawInternal medicinemedicineHumansAcute Coronary SyndromeAspirinbusiness.industryMaintenance doseGeneral Medicinemedicine.diseasede-escalationTolerabilityELECTRA-SIRIO 2 ; acute coronary syndrome ; antiplatelet therapy ; de-escalation ; ticagrelorCardiologyCardiology and Cardiovascular MedicinebusinessTicagrelorDe-escalationPlatelet Aggregation Inhibitorsmedicine.drug
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High definition colonoscopy combined with i-Scan is superior in the detection of colorectal neoplasias compared with standard video colonoscopy: a pr…

2010

Introduction Colonoscopy is the accepted gold standard for the detection of colorectal cancer. The aim of the current study was to prospectively compare high definition plus (HD+) colonoscopy with I-Scan functionality (electronic staining) vs. standard video colonoscopy. The primary endpoint was the detection of patients having colon cancer or at least one adenoma. Methods A total of 220 patients due to undergo screening colonoscopy, postpolypectomy surveillance or with a positive occult blood test were randomized in a 1 : 1 ratio to undergo HD+ colonoscopy in conjunction with I-Scan surface enhancement (90i series, Pentax, Tokyo, Japan) or standard video colonoscopy (EC-3870FZK, Pentax). D…

AdenomaMalemedicine.medical_specialtyAdenomaColorectal cancerColonoscopyColonic PolypsGastroenterologylaw.inventionRandomized controlled triallawInternal medicineClinical endpointmedicineHumansProspective StudiesProspective cohort studyEarly Detection of CancerAgedmedicine.diagnostic_testbusiness.industryGastroenterologyGold standard (test)ColonoscopyMiddle Agedmedicine.diseaseImage EnhancementEndoscopyFemaleRadiologybusinessColorectal NeoplasmsEndoscopy
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Comparison of the yield from two faecal immunochemical tests at identical cutoff concentrations – a randomized trial in Latvia

2016

OBJECTIVE We have compared the performance of two faecal immunochemical tests (FIT) in an average-risk population. MATERIALS AND METHODS Altogether, 10 000 individuals aged 50-74 were selected randomly from the population of Latvia in 2011 and assigned randomly either to OC-Sensor or to FOB Gold single-time testing. Positivity of the test, frequency of colonic lesions, number needed to screen (NNscreen) and scope for the detection of an advanced neoplasm (cancer and advanced adenoma) were compared between the tests using the same cutoff concentrations in µg/g faeces. Confidence intervals (CIs) at 95% were calculated. RESULTS Positivity with the cutoff set at 10 µg/g faeces was 12.8% (95% CI…

AdenomaMalemedicine.medical_specialtyPopulationColonoscopyGastroenterologylaw.invention03 medical and health sciences0302 clinical medicineRandomized controlled trialPredictive Value of TestslawInternal medicineHumansMass ScreeningMedicineCutoffeducationFecesAgededucation.field_of_studyHepatologymedicine.diagnostic_testbusiness.industryGastroenterologyReproducibility of ResultsColonoscopyMiddle AgedImmunohistochemistryLatviaNumber needed to screenConfidence intervalOccult Blood030220 oncology & carcinogenesisPredictive value of testsFemale030211 gastroenterology & hepatologyColorectal NeoplasmsbusinessEuropean Journal of Gastroenterology & Hepatology
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Intraprocedural bowel cleansing with the JetPrep cleansing system improves adenoma detection.

2014

AIM: To investigate the impact of JetPrep cleansing on adenoma detection rates. METHODS: In this prospective, randomized, crossover trial, patients were blindly randomized to an intervention arm or a control arm. In accordance with the risk profile for the development of colorectal carcinoma, the study participants were divided into high-risk and low-risk groups. Individuals with just one criterion (age > 70 years, adenoma in medical history, and first-degree relative with colorectal cancer) were regarded as high-risk patients. Bowel preparation was performed in a standardized manner one day before the procedure. Participants in the intervention arm underwent an initial colonoscopy with sta…

AdenomaMalemedicine.medical_specialtyRandomizationendocrine system diseasesColorectal cancerColonoscopyTherapeutic irrigationColonic PolypsGroup BAdenomatous PolypsPredictive Value of TestsRisk FactorsMedicineHumansProspective StudiesDiagnostic ErrorsProspective cohort studyTherapeutic IrrigationEarly Detection of CancerAgedCross-Over Studiesmedicine.diagnostic_testbusiness.industryGastroenterologyGeneral MedicineColonoscopyEquipment DesignMiddle Agedmedicine.diseasePrognosisCrossover studydigestive system diseasesSurgerystomatognathic diseasesPredictive value of testsRandomized Controlled TrialFemalebusinessColorectal NeoplasmsWorld journal of gastroenterology
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Relation between health literacy, self-care and adherence to treatment with oral anticoagulants in adults: a narrative systematic review

2018

Background Oral anticoagulants (OAC) are widely used in patients with cardiovascular diseases. However, for optimal OAC self-care patients must have skills, among which health literacy (HL) is highlighted. We aimed to describe the relation between HL and self-care in cardiovascular patients on OAC treatment. Methods Electronic searches were carried out in the PubMed, Scopus, Embase, CINAHL, Web of Science, Cochrane Library, SciELO, IME-Biomedicina, CUIDEN Plus and LILACS databases, limited to Spanish and English language and between January 2000–December 2016. Papers reported on adults older than 18 years, taking OAC by themselves for at least three months. PRISMA guidelines were used for p…

Administration OralSalud030204 cardiovascular system & hematologyCochrane Library0302 clinical medicineEpidemiology030212 general & internal medicinePublic Environmental & Occupational HealthRandomized Controlled Trials as TopicOUTCOMESSelf-managementWARFARIN THERAPYNarrationlcsh:Public aspects of medicineASSOCIATIONCor Malalties1117 Public Health And Health ServicesCardiovascular DiseasesHEART-FAILUREPublic HealthSelf-careLife Sciences & BiomedicineResearch Articlemedicine.drugAdultmedicine.medical_specialtyHealth literacyCINAHLMedication Adherence03 medical and health sciencesMEDICATIONmedicineSelf-managementMANAGEMENTQUALITYHumansKNOWLEDGEScience & Technologybusiness.industryPublic healthMORTALITYPublic Health Environmental and Occupational HealthWarfarinHealth literacyAnticoagulantslcsh:RA1-1270R1Self CareAdherenceFamily medicineATRIAL-FIBRILLATIONAnticoagulants (Medicina)Systematic reviewOral coagulation therapyBiostatisticsbusinessRA
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Outcomes of single versus double hormone receptor–positive breast cancer. A GEICAM/9906 sub-study

2018

Abstract Background Retrospective data suggest better outcomes for patients with double hormonal receptor (oestrogen [ER] and progesterone receptor [PgR])–positive (dHR+) early breast cancer, compared with single hormonal receptor–positive, sHR+, (ER+/PgR– or ER–/PgR+) disease. Here, we evaluate the classification according to intrinsic subtypes and clinical outcomes of sHR+ versus dHR+ in HER2-negative breast cancer patients enrolled in GEICAM/9906 study ( NCT00129922 ). Methods Archival tumours were retrieved retrospectively for the analysis of ER, PgR and HER2 status and classified into intrinsic subtypes using the PAM50 gene expression assay. Disease-free survival (DFS) and overall surv…

Adult0301 basic medicineOncologyendocrine systemCancer Researchmedicine.medical_specialtyPaclitaxelBreast NeoplasmsDisease-Free Survival03 medical and health sciencesBreast cancer0302 clinical medicineBreast cancerInternal medicineAntineoplastic Combined Chemotherapy ProtocolsProgesterone receptormedicineHumansPAM50Single receptor positiveskin and connective tissue diseasesReceptorCyclophosphamideAgedEpirubicinProportional Hazards ModelsRandomized Controlled Trials as TopicRetrospective StudiesHormone receptor positivebusiness.industryIncidence (epidemiology)Hazard ratioLuminal aMiddle Agedmedicine.disease030104 developmental biologyClinical Trials Phase III as TopicReceptors EstrogenOncologyIntrinsic subtypesHormone receptor030220 oncology & carcinogenesisFemaleFluorouracilReceptors ProgesteroneTranscriptomebusinesshormones hormone substitutes and hormone antagonistsHormoneEuropean Journal of Cancer
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