Search results for "Randomized Controlled Trial"
showing 10 items of 2199 documents
The effects of three remineralizing agents on regression of white spot lesions in children: A two-week, single-blind, randomized clinical trial.
2016
Background This study investigated the effect of three remineralizing agents on improving white spot lesions (WSLs). Material and Methods This clinical trial included children who had at least one WSL on anterior teeth of upper or lower jaws. The participants were randomly assigned to 4 groups by treatment: 1) a cream containing casein phosphopeptide-amorphous calcium phosphate and fluoride (MI Paste Plus); 2) a cream containing hydroxyapatite and fluoride (Remin Pro); 3) a 2% sodium fluoride gel; and 4) usual home care (control). The treatment was performed for 3 times over 10 days using special trays for retaining remineralizing agents. The area and mineral content of WSLs were measured a…
157 Patient satisfaction and safety of sedation using perineurial dexmedetomidine in axillary brachial plexus block for wrist surgery
2021
Background and Aims Dexmedetomidine is known to prolong the duration of regional block while its sedative effect when administered perineurally is unknown.[1] We aim to evaluate the effect of perineural Dexmedetomidine on the systemic sedation in patients after axillary brachial plexus block (ABPB). Methods This prospective randomized control trial includes 78 patients undergoing wrist surgery receiving ABPB. The study was conducted with the approval of Ethics Committee of Riga Stradins University. Patients were randomized into two groups – control (CG) (N=39) and study group (SG) (N=39). Both groups received ABPB with a standard dose of local anaesthetics. The study group also received 100…
Effect of preemptive analgesia with ibuprofen in the control of postoperative pain in dental implant surgeries: A randomized, triple-blind controlled…
2019
Background Preemptive analgesia has as its basic principle the administration of analgesics before the onset of painful stimuli, in order to reduce or prevent postoperative pain, but this question is little explored in implantology. Thus, this study was conducted in order to evaluate the clinical efficacy of ibuprofen in pain prevention after unit implant surgery. Material and Methods For this triple-blind, parallel, placebo-controlled and randomized clinical trial, 54 insertion surgeries of unitary implants were performed. Two groups have received two different protocols 1 hour before surgery: Ibuprofen group (IBU) 600 mg of ibuprofen; and (2) placebo group (maize starch). The intensity of…
1649 Retrospective Analysis of Doxapram for the Treatment of Apnea of Prematurity
2012
Background and Aims Only one small randomized controlled study on doxapram to treat apnea of prematurity is available. Before the implementation of a local treatment protocol, we aimed to evaluate the frequency of administration of doxapram in our NICU. We asked, if frequency and severity of apneas were affected by doxapram, if intubation for apnea was avoided, and if side effects occurred. Methods We retrospectively analysed all premature infants Results 17 of 64 (27%) infants (mean gestational age 26.1 weeks, mean birth weight 733g) were treated during two years. All of them had been treated with caffeine before doxapram was applied. 70 therapy courses of 16 infants were analyzed. In 8 of…
A randomized controlled trial of a power brush/irrigator/mouthrinse routine on plaque and gingivitis reduction in orthodontic patients
2018
ABSTRACT Objectives: To assess plaque and gingivitis reduction in orthodontic patients after 4 weeks' use of an oscillating-rotating power brush, irrigator, and mouthrinse. Materials and Methods: This was a randomized, examiner-blind, clinical trial comparing plaque and gingivitis outcomes for an experimental power brush/irrigator/mouthrinse oral hygiene routine vs a dental prophylaxis followed by regular manual brushing (positive control). Fifty-one participants with fixed orthodontic appliances in the upper and lower jaw and a minimum of 15 gingival bleeding sites were randomly assigned to experimental or positive control treatment. Both groups were instructed to use their products at lea…
Zotepin versus Perazin bei Patienten mit paranoider Schizophrenie: eine doppelblind-kontrollierte Wirksamkeitsprüfung
1991
The dibenzothiepine zotepine is a new potential "atypical" neuroleptic exhibiting powerful antiserotonergic and antidopaminergic properties. The efficacy of zotepine was evaluated in a double-blind controlled trial versus the tricyclic neuroleptic perazine in 41 patients suffering mainly from the paranoid-hallucinatory type of schizophrenia. The key outcome variable was the extent of mental disturbance as defined by the total score of the BPRS. Additional outcome variables were GAS and CGI. In addition, adverse reactions and extrapyramidal side effects were assessed according to the FSUCL scale and the Gerlach and AIMS rating scale, respectively. Additional variables recorded were blood pre…
Reduced muscle inactivity, sedentary time and cardio-metabolic benefits : effectiveness of a one-year family-based cluster randomized controlled trial
2016
A driving hypothesis of the evolving field of sedentary behavior is that frequent muscle activity short-circuits detrimental physiological effects of sedentary time. However, the field relies mostly on observational health associations of proxy measures of muscle inactivity, like television viewing or lack of accelerometer-derived impacts. This study tested effectiveness of a family-based cluster-randomized controlled trial aimed at reducing and breaking up sedentary time at work and leisure time of families on muscle inactivity patterns, sedentary time and cardio-metabolic biomarkers. The intervention consisted of a lecture, face-to-face tailored counseling, two follow-up calls and five em…
STEM CELLS FOR TREATMENT OF CARDIOVASCULAR DISEASES: AN UMBRELLA REVIEW OF RANDOMIZED CONTROLLED TRIALS
2021
AIMS:\ud \ud Stem cells are a promising therapy for various medical conditions. The literature regarding their adoption for the clinical care of cardiovascular diseases (CVD) is still conflicting. Therefore, our aim is to assess the strength and credibility of the evidence on clinical outcomes and application of stem cells derived from systematic reviews and meta-analyses of intervention studies in CVD.\ud \ud METHODS and RESULTS:\ud \ud Umbrella review of systematic reviews with meta-analyses of randomized controlled trials (RCTs) using placebo/no intervention as control group. For meta-analyses of RCTs, outcomes with a random-effect p-value< 0.05, the GRADE (Grading of Recommendations Ass…
A randomized multicenter trial on a lung ultrasound-guided treatment strategy in patients on chronic hemodialysis with high cardiovascular risk
2021
Lung congestion is a risk factor for all-cause and cardiovascular mortality in patients on chronic hemodialysis, and its estimation by ultrasound may be useful to guide ultrafiltration and drug therapy in this population. In an international, multi-center randomized controlled trial (NCT02310061) we investigated whether a lung ultrasound-guided treatment strategy improved a composite end point (all-cause death, non-fatal myocardial infarction, decompensated heart failure) vs usual care in patients receiving chronic hemodialysis with high cardiovascular risk. Patient-Reported Outcomes (Depression and the Standard Form 36 Quality of Life Questionnaire, SF36) were assessed as secondary outcome…
Safety and efficacy of cervical disc arthroplasty in preventing the adjacent segment disease: a meta-analysis of mid- to long-term outcomes in prospe…
2019
Objectives: Cervical disc arthroplasty (CDA) has become an alternative treatment for cervical radiculopathy and myelopathy. This technique preserves appropriate motion at both the index and adjacent disc levels and consequently may prevent adjacent segment degeneration (ASD). The authors performed a meta-analysis to compare the safety and efficacy of CDA to those of the gold standard, anterior cervical discectomy and fusion (ACDF). Both surgical and clinical parameters were employed to verify the hypothesis that CDA can reduce the risk of ASD. Methods: The meta-analysis comprised high-quality randomized controlled trials that compared CDA and ACDF treatments of cervical degenerative disc di…