Search results for "Randomized"
showing 10 items of 2323 documents
Controlled trial for long-term low-dose erythromycin after sinus surgery for chronic rhinosinusitis
2014
Objectives/Hypothesis The efficacy of macrolides in chronic rhinosinusitis (CRS) is still under controversy. To date, only two double-blind, placebo-controlled studies have been published with differing results. None of these studies investigated the possible benefit of macrolides in the postoperative period. We conducted an investigator-initiated clinical trial using 250-mg erythromycin once a day over a period of 3 months, beginning the administration of either erythromycin or placebo 2 weeks after a surgical intervention for CRS. Study Design Randomized double-blind, placebo-controlled trial. Methods The concentrations of eosinophilic cationic protein (ECP) and myeloperoxidase in nasal s…
Psychological therapies for adolescents with borderline personality disorder (BPD) or BPD features-A systematic review of randomized clinical trials …
2021
Objectives To review the effectiveness of psychological therapies for adolescents with borderline personality disorder (BPD) or BPD features. Methods We included randomized clinical trials on psychological therapies for adolescents with BPD and BPD features. Data were extracted and assessed for quality according to Cochrane guidelines, and summarized as mean difference (MD) with 95% confidence intervals (CI) for continuous data and as Odds ratios (OR) with 95% CI for dichotomous data. Risk of bias was assessed using Cochrane’s risk of bias tool for each domain. When possible, we pooled trials into meta-analyses, and used Trial Sequential Analysis (TSA) to control for random errors. Quality…
Metabolic and Vascular Effect of the Mediterranean Diet
2019
Several studies indicated how dietary patterns that were obtained from nutritional cluster analysis can predict disease risk or mortality. Low-grade chronic inflammation represents a background pathogenetic mechanism linking metabolic risk factors to increased risk of chronic degenerative diseases. A Mediterranean diet (MeDi) style has been reported as associated with a lower degree of inflammation biomarkers and with a protective role on cardiovascular and cerebrovascular events. There is heterogeneity in defining the MedDiet, and it can, owing to its complexity, be considered as an exposome with thousands of nutrients and phytochemicals. Recently, it has been reported a novel positive ass…
Effect of a prenatal lifestyle intervention on physical activity level in late pregnancy and the first year postpartum
2017
Background: Despite documented health benefits for mother and baby, physical activity (PA)-level tends to decline in pregnancy. Overweight/obese and physically inactive women are two selected groups at increased risk of pregnancy complications. Thus, efficient strategies to maintain or increase PA-level in pregnancy and the postpartum period, especially among these women, are warranted. This secondary analysis examined the effect of a prenatal lifestyle-intervention on PA-level in late pregnancy and the first year postpartum, with subanalysis on initially physically active versus inactive and normal-weight versus overweight/obese women. Method: The Norwegian Fit for Delivery (NFFD) randomiz…
Global collaborative networks on meta-analyses of randomized trials published in high impact factor medical journals: a social network analysis
2014
Abstract Background Research collaboration contributes to the advancement of knowledge by exploiting the results of scientific efforts more efficiently, but the global patterns of collaboration on meta-analysis are unknown. The purpose of this research was to describe and characterize the global collaborative patterns in meta-analyses of randomized trials published in high impact factor medical journals over the past three decades. Methods This was a cross-sectional, social network analysis. We searched PubMed for relevant meta-analyses of randomized trials published up to December 2012. We selected meta-analyses (including at least randomized trials as primary evidence source) published in…
An evidence based therapeutic approach to hereditary and acquired angioedema
2014
Purpose of review Hereditary angioedema (HAE) due to C1 esterase inhibitor (C1-INH) deficiency (HAE-C1-INH), HAE with normal C1-INH, and acquired angioedema due to C1-INH deficiency are rare but important diseases that can be associated with significant morbidity and mortality. Research into the pathogenesis of angioedema has expanded greatly and has led to new clinical trials with novel therapeutic agents and strategies. Recent findings Strategies for managing HAE-C1-INH are aimed at treating acute attacks or preventing attacks through the use of prophylactic treatment. Agents available in Europe for treating acute attacks include plasma-derived C1-INH concentrates, a bradykinin B2 recepto…
LABA/LAMA fixed-dose combinations in patients with COPD: A systematic review
2018
Paola Rogliani,1 Luigino Calzetta,1 Fulvio Braido,2 Mario Cazzola,1 Enrico Clini,3 Girolamo Pelaia,4 Andrea Rossi,5 Nicola Scichilone,6 Fabiano Di Marco7 1Department of Experimental Medicine and Surgery, University of Rome Tor Vergata, Rome, Italy; 2Department of Internal Medicine, IRCCS San Martino Genoa University Hospital, Genoa, Italy; 3Department of Medical and Surgical Sciences, University of Modena and Reggio Emilia, Modena, Italy; 4Department of Medical and Surgical Sciences, Section of Respiratory Diseases, Magna Græcia University, Catanzaro, Italy; 5Pulmonary Unit, University of Verona, Verona, Italy; 6Department of Internal Medicine, University of Palermo, Palermo, Italy; 7…
Separations in Query Complexity Based on Pointer Functions
2015
In 1986, Saks and Wigderson conjectured that the largest separation between deterministic and zero-error randomized query complexity for a total boolean function is given by the function $f$ on $n=2^k$ bits defined by a complete binary tree of NAND gates of depth $k$, which achieves $R_0(f) = O(D(f)^{0.7537\ldots})$. We show this is false by giving an example of a total boolean function $f$ on $n$ bits whose deterministic query complexity is $\Omega(n/\log(n))$ while its zero-error randomized query complexity is $\tilde O(\sqrt{n})$. We further show that the quantum query complexity of the same function is $\tilde O(n^{1/4})$, giving the first example of a total function with a super-quadra…
Fast computation of abelian runs
2016
Given a word $w$ and a Parikh vector $\mathcal{P}$, an abelian run of period $\mathcal{P}$ in $w$ is a maximal occurrence of a substring of $w$ having abelian period $\mathcal{P}$. Our main result is an online algorithm that, given a word $w$ of length $n$ over an alphabet of cardinality $\sigma$ and a Parikh vector $\mathcal{P}$, returns all the abelian runs of period $\mathcal{P}$ in $w$ in time $O(n)$ and space $O(\sigma+p)$, where $p$ is the norm of $\mathcal{P}$, i.e., the sum of its components. We also present an online algorithm that computes all the abelian runs with periods of norm $p$ in $w$ in time $O(np)$, for any given norm $p$. Finally, we give an $O(n^2)$-time offline randomi…
Forrelation
2014
We achieve essentially the largest possible separation between quantum and classical query complexities. We do so using a property-testing problem called Forrelation, where one needs to decide whether one Boolean function is highly correlated with the Fourier transform of a second function. This problem can be solved using 1 quantum query, yet we show that any randomized algorithm needs Ω(√(N)log(N)) queries (improving an Ω(N[superscript 1/4]) lower bound of Aaronson). Conversely, we show that this 1 versus Ω(√(N)) separation is optimal: indeed, any t-query quantum algorithm whatsoever can be simulated by an O(N[superscript 1-1/2t])-query randomized algorithm. Thus, resolving an open questi…