Search results for "RasGrf1"

showing 3 items of 3 documents

Transcriptional profiling reveals functional links between RasGrf1 and Pttg1 in pancreatic beta cells

2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License .

MaleComputingMilieux_LEGALASPECTSOFCOMPUTINGTranscriptomeCytosolRas-GRF1Insulin-Secreting CellsGlucose homeostasisPromoter Regions GeneticOligonucleotide Array Sequence AnalysisMice KnockoutGeneticsCell biologySecurinERKPhenotypemedicine.anatomical_structureMitogen-Activated Protein KinasesBeta cellSignal transductionResearch ArticleSignal TransductionBiotechnologyCell signalingMedicina InvestigacióMedicinaPancreatic isletsBiologyGeneticsmedicineAnimalsCell LineagePttg1TranscriptomicsTranscription factorBinding Sitesras-GRF1Gene Expression ProfilingPancreatic isletsBeta cellsMolecular Sequence AnnotationGlucose Tolerance TestMice Inbred C57BLPàncrees MalaltiesGenetic LociData_GENERALTranscriptional factorsras ProteinsCalciumRasGrf1RasBMC Genomics
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Spatial learning and long-term memory impairments in RasGrf1 KO, Pttg1 KO, and double KO mice

2018

© 2018 The Authors.

0301 basic medicineMaleMemory Long-TermHippocampusSpatial learningBiologyHippocampusBarnes mazememory03 medical and health sciencesBehavioral Neuroscience0302 clinical medicineDiscrimination PsychologicalMemoryAnimalsPttg1Maze LearningChromosome separationOriginal ResearchMice KnockoutPCALong-term memoryras-GRF1spatial learningBrainBarnes mazeMice Inbred C57BLSecurin030104 developmental biologySecurinCervell Localització de funcionsMemory consolidationFemaleSignal transductionBeta cellRasGrf1Neuroscience030217 neurology & neurosurgerySignal Transduction
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Computational methodologies applied to Protein-Protein Interactions for molecular insights in Medicinal Chemistry

2021

In living systems, proteins usually team up into “molecular machinery” implementing several protein-to-protein physical contacts – or protein-protein interactions (PPIs) – to exert biological effects at both cellular and systems levels. Deregulations of protein-protein contacts have been associated with a huge number of diseases in a wide range of medical areas, such as oncology, cancer immunotherapy, infectious diseases, neurological disorders, heart failure, inflammation and oxidative stress. PPIs are very complex and usually characterised by specific shape, size and complementarity. The protein interfaces are generally large, broad and shallow, and frequently protein-protein contacts are…

InflammationComputer-Aided Drug DesignMolecular DynamicFactor HMolecular ModelingCOVID-19ACE2MUC1SpikeDrug AddictionHOXComputational Alanine ScanningC3bSettore CHIM/08 - Chimica FarmaceuticaProtein-Protein InteractionMolecular DockingComputational ChemistryNLRP3PBXCIN85RasGRF1RaCancer
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