Search results for "Rash"
showing 10 items of 377 documents
Phase Ib Trial Trial of Rg7116, a Glycoengineered Monoclonal Antibody Targeting Her3, in Combination with Cetuximab or Erlotinib in Patients with Adv…
2014
ABSTRACT Aim: To evaluate the safety profile of RG7116 in combination with cetuximab or erlotinib. Methods: Patients (pts) with advanced or metastatic carcinomas with centrally confirmed HER3 protein expression were included. RG7116 plus cetuximab (400 mg/m2 followed by 250 mg/m2 qw IV) and RG7116 plus erlotinib (150 mg/day p.o.) combinations were evaluated in a dose escalation study with “3 + 3” design at a starting dose of 400 mg IV of RG7116 in a q2w regimen. Results: Twenty-seven pts were enrolled in 5 cohorts (400 to 2000 mg) in the cetuximab arm. One dose-limiting toxicity (DLT) of grade 3 dehydration was reported in the 800-mg cohort. Twenty-seven pts were enrolled in 4 cohorts (400 …
PD-0024 Phase I/II Study of Folfiri Plus the MEK1/2 Inhibitor Pimasertib (MSC1936369B) as Second-Line Treatment for KRAS Mutated Metastatic Colorecta…
2012
ABSTRACT Introduction Pimasertib is a highly selective inhibitor of the MEK1/2 kinases of the MAPK pathway. It demonstrates potent antitumor activity in cell lines and xenograft models with activating (mainly BRAF and KRAS) mutations. A two-part study, comprising a safety run-in part followed by a randomized phase II part, was designed to investigate FOLFIRI plus pimasertib as second-line treatment for patients with KRAS mutated (mt) metastatic colorectal cancer (mCRC). The results of the safety run-in part, conducted primarily to determine the maximum tolerated dose (MTD) and the recommended phase II dose (RP2D), are reported here. Methods Patients with KRAS mt mCRC progressing on first-li…
Amplifier similariton fibre laser with nonlinear spectral compression
2012
We propose and numerically demonstrate a new concept of fibre laser architecture supporting self-similar pulse evolution in the amplifier and nonlinear pulse spectral compression in the passive fibre. The latter process is beneficial for improving the power efficiency as it prevents strong spectral filtering from being highly dissipative.
Ultrafast Gain Recovery in Quantum Dot based Semiconductor Optical Amplifiers
2007
Summary form only given. The limiting factor in ultrahigh bit rate amplification is the ultrafast population recovery in the resonant level, which is mainly limited by carrier capture and relaxation processes in the QD. We use pump-probe measurements resonant to the QDs confined states energies (ground and excited state) to investigate the response to a four fs-pulse train of 1 THz repetition rate. A deep insight about the capture process implied is then obtained, and direct capture from the wetting layer is identified as the dominant mechanism in the high current regime.
Linear and nonlinear fiber propagation of partially coherent fields exhibiting temporal correlations
2019
International audience; Using ultrafast photonic first-order differentiator applied on a partially coherent field, we report the generation of two correlated temporal waveforms and study their correlation properties upon linear and nonlinear propagation along the two orthogonal polarization axis of a dispersive optical fiber. Temporal correlations are maintained in linear propagation whereas Kerr nonlinearity generates anti-correlated temporal intensity patterns for both partially and uncorrelated fields. Experiments are in close agreement with the theoretical analysis.
Spatial beam self-cleaning in multimode fibres
2017
Multimode optical fibres are enjoying a renewed attention, boosted by the urgent need to overcome the current capacity crunch of single-mode fibre systems and by recent advances in multimode complex nonlinear optics [1-13]. In this work, we demonstrate that standard multimode fibres can be used as ultrafast all-optical tool for transverse beam manipulation of high power laser pulses. Our experimental data show that the Kerr effect in a graded-index multimode fibre is the driving mechanism for overcoming speckle distortions, leading to a somewhat counter-intuitive effect resulting in a spatially clean output beam robust against fibre bending. Our observations demonstrate that nonlinear beam …
Fiber-based measurement of temporal intensity and phase profiles of an optical telecommunication pulse through self-phase modulation
2018
International audience; We propose and experimentally validate an all-fiber based approach to characterize the phase and intensity profiles of optical pulses. Based on three optical spectra affected by different levels of self-phase modulation, we were able to reconstruct the temporal details of pulses typical of optical telecommunications.
Predicting ultrafast nonlinear dynamics in optical fiber using neural networks
2021
We show how neural networks can be used to model complex and predict nonlinear propagation dynamics in optical fibres for a widerange of input conditions and fibre systems, including pulse compression, ultra-broadband supercontinuum generation, and multimode fiber systems. Our results open up novel perspectives to model and optimize complex nonlinear dynamics and systems.
<title>Spin-polarized electron kinetics under high-intensity picosecond excitation</title>
2003
ABSTRACT Spin-polarized electron kinetics is studied by time-resolved polarized photoemission with picosecond resolution. The re-sponse time of strained layer photocathodes is found to be in a range of a few picosecond offering an ultrafast response andhigh spin-polarization of emitted electrons. The studies of the sub-picosecond spin dynamics are facilitated in high-intensityexcitation regime when the length of the emission pulse is enlarged due to the dispersion of acceleration time and Coulombrepulsion ofthe electrons in their flight in the vacuum.Keywords: optical orientation, spin kinetics, strained semiconductor layer, time-resolved emission. 1. INTRODUCTION GaAs, layers are known to …