Search results for "Ratas"
showing 10 items of 94 documents
Tiempos de Cruzada
1998
La Europa de Blair / 1. La tercera vía
2005
El capitalismo, contra el planeta / 5
2007
Europa en la Calle
2000
Neuron-specific enolase--a serum marker for malignant melanoma.
1989
No nos equivoquemos de cadáveres
2006
Cultura y Disidencia
1997
Pequeño texto de José Vidal-Beneyto en relación con la asociación cultural "Memoria democrática" y la semana "Cultura y Disidencia", organizada en el Círculo de Bellas Artes de Madrid del 17 al 23 de noviembre de 1997.
Lentes intraoculares multifocales refractivas de nuevo diseño segmentado
2017
La presbicia y las cataratas son dos condiciones oculares relacionadas con el envejecimiento del cristalino, que presentan una elevada incidencia conjunta por encima de los 60 años. Dada la tendencia, claramente visible en los estudios de pirámides poblacionales, al envejecimiento en la población mundial por la mayor esperanza de vida, ambas condiciones van a tener una enorme incidencia en el futuro. Ambas comparten una opción terapéutica común: la sustitución del cristalino por una lente intraocular multifocal (LIOMTF), que permite a los pacientes restaurar su visión y además obtener un amplio rango de distancias con visión funcional sin necesidad de ayudas ópticas. En la actualidad existe…
Myc Promoter-Binding Protein-1 (MBP-1) Is a Novel Potential Prognostic Marker in Invasive Ductal Breast Carcinoma
2010
BackgroundAlpha-enolase is a glycolytic enzyme that catalyses the formation of phosphoenolpyruvate in the cell cytoplasm. α-Enolase and the predominantly nuclear Myc promoter-binding protein-1 (MBP-1) originate from a single gene through the alternative use of translational starting sites. MBP-1 binds to the P2 c-myc promoter and competes with TATA-box binding protein (TBP) to suppress gene transcription. Although several studies have shown an antiproliferative effect of MBP-1 overexpression on several human cancer cells, to date detailed observations of α-enolase and MBP-1 relative expression in primary tumors versus normal tissues and their correlation with clinicopathological features ha…
ENO1 gene product binds to the c-myc promoter and acts as a transcriptional repressor: relationship with Myc promoter-binding protein 1 (MBP-1).
2000
The Myc promoter-binding protein-1 (MBP-1) is a 37-38 kDa protein that binds to the c-myc P2 promoter and negatively regulates transcription of the protooncogene. MBP-1 cDNA shares 97% similarity with the cDNA encoding the glycolytic enzyme alpha-enolase and both genes have been mapped to the same region of human chromosome 1, suggesting the hypothesis that the two proteins might be encoded by the same gene. We show here data indicating that a 37 kDa protein is alternatively translated from the full-length alpha-enolase mRNA. This shorter form of alpha-enolase is able to bind the MBP-1 consensus sequence and to downregulate expression of a luciferase reporter gene under the control of the c…