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Agrestis cum erudito: scenografie del discorso nell’Apologia di Apuleio
2017
In Apologia Apuleius’s speech shows a rich ‘geography’: private homes, shops, villas and inns are the ingredients of a rhetorical strategy aimed at emphasizing the cultural and ethical distance between accusation and defense. An important role is played by the topical contrast between the country and the city, used to make a strong impact on the public and on the judge and to dismantle and discredit 'a priori' the accusations. In Apologia, therefore, the places are not only the background to the trial but are also conceived as a scenery of the word and as a ‘visual’ instrument to outline the parties involved.
Etanercept maintains the clinical benefit achieved by infliximab in patients with rheumatoid arthritis who discontinued infliximab because of side ef…
2007
Objective: To evaluate the efficacy of switching to etanercept treatment in patients with rheumatoid arthritis who already responded to infliximab, but presented side effects. Methods: Charts of 553 patients with rheumatoid arthritis were retrospectively reviewed to select patients who responded to the treatment with infliximab and switched to etanercept because of occurrence of adverse effects. Clinical data were gathered during 24 weeks of etanercept treatment and for the same period of infliximab treatment before infliximab was stopped. Disease Activity Score computed on 44 joints (DAS-44), erythrocyte sedimentation rate (ESR) 1st hour, Visual Analogue Scale (VAS) of pain, Health Assessm…
Mtlinteracts with members of Egfr signaling and cell adhesion genes in the Drosophila eye
2011
Mtl is a member of the Rho family of small GTPases in Drosophila. It was shown that Mtl is involved in planar cell polarity (PCP) establishment, together with other members of the same family like Cdc42, Rac1, Rac2 and RhoA. However, while Rac1, Rac2 and RhoA function downstream of Dsh in Fz/PCP signaling and upstream of a JNK cassette, Mtl and Cdc42 do not. To determine the functional context of Mtl during PCP establishment in the Drosophila eye, we performed a loss-of-function screen to search for dominant modifiers of a sev>Mtl rough eye phenotype. In addition, genetic interaction assays with candidate genes were also carried out. Our results show that Mtl interacts genetically with memb…
Metabotropic glutamate receptors activate phospholipase D in astrocytes through a protein kinase C-dependent and Rho-independent pathway.
2003
Metabotropic glutamate receptors (mGluRs) are G protein-coupled receptors that mediate phospholipase D (PLD) activation in brain, but the mechanism underlying this response remains unclear. Here we used primary cultures of astrocytes as a cell model to explore the mechanism that links mGluRs to PLD. Glutamate activated both phospholipase C (PLC) and PLD with equal potency and this effect was mimicked by L-cysteinesulfinic acid, a putative neurotransmitter previously shown to activate mGluRs coupled to PLD, but not PLC, in adult brain. PLD activation by glutamate was dependent on Ca(2+) mobilization and fully blocked by both protein kinase C (PKC) inhibitors and PKC down-regulation, suggesti…
Strategic Cyber Environment Management with Zero Trust and Cyber Counterintelligence
2022
Organisations need to improve their information security practices, given the volume of successful cyberattacks and crimes. To enhance security in an organisation, information security must be considered a business issue, instead of a technical problem. Hence, organisations must change the security protocol from reactive action to proactive operation; must develop information security strategies that support the business; should implement better controls, systems, and services; and must create a process to proactively gather information about the possible threats and adversaries. This study proposes a novel method for combining a zero-trust strategy with cyber counterintelligence to gain th…
Nitrate and nitrite in the diet: How to assess their benefit and risk for human health
2015
Nitrate is a natural constituent of the human diet and an approved food additive. It can be partially converted to nitrogen monoxide, which induces vasodilation and thereby decreases blood pressure. This effect is associated with a reduced risk regarding cardiovascular disease, myocardial infarction, and stroke. Moreover, dietary nitrate has been associated with beneficial effects in patients with gastric ulcer, renal failure, or metabolic syndrome. Recent studies indicate that such beneficial health effects due to dietary nitrate may be achievable at intake levels resulting from the daily consumption of nitrate-rich vegetables. N-nitroso compounds are endogenously formed in humans. However…
Risk stratification at primary care centres in Valencia (Spain) to activate integrated care pathways for elderly patients with chronic conditions
2017
Introduction: The activation of integrated care pathways is not always easy and is time-consuming, so the standardized use of stratification tools (ST) can support health care professionals in decision-making processes. Several ST –developed and validated in the United States– have been implemented in the Valencia Region (Spain) at primary care (PC) centres to identify elders with multimorbidity at risk of suffering future hospital admissions (FHA). In spite of the usefulness of these instruments, it would be recommended to apply STs which have been specifically designed on the basis of the Spanish healthcare system and the characteristics of its population. Thus, the objective of this stud…
Analysis of nitrite and nitrate in foodstuffs-Method development, ocurrence, regulation, metrological aspects and exposure
2017
La presencia y la inocuidad de los nitritos y nitratos son un tema controvertido. El nitrito es un aditivo autorizado considerado como un ingrediente importante para la preservación de productos cárnicos. Nitrato es un componente natural de la dieta humana que, sin embargo, despierta preocupación por su supuesta potencial nocividad relacionada con cianosis, carcinogénesis y contaminación ambiental. Por lo tanto, determinaciones confiables de nitrito/nitrato son necesarias por tres razones principales: a) vigilar el cumplimiento de las regulaciones actuales sobre aditivos y contaminantes, b) determinar el contenido de nitrito/nitrato in alimentos, dietas y agua potables y c) estudiar el comp…
Défricher les chemins vers l'entreprise responsable, le cas de la prévention des Risques Psychosociaux
2017
How to formalize new concepts and / or build new management tools that are consistent with an responsible approach? Through the field study of the prevention of psychosocial risks at work (PSR), our work illustrates the difficulty faced by researchers and practitioners in the context of a responsiblecorporate approach. The multiple possible approaches of the prevention of PSR are all ways leading to management choices with contrasted methods and results. That makes it necessary for researchers and practitioners to position themselves upstream from these choices.