Search results for "Rates"
showing 10 items of 1636 documents
Socrate e il mare. Il modello odissiaco nel Fedone
2015
Nel Fedone Platone traccia una biografia intellettuale di Socrate articolata in vari momenti. L’ultimo di essi (τὸν δεύτερον πλοῦν, la “seconda navigazione”) consiste nel passaggio dall’osservazione naturalistica ad una fi- losofia orientata in senso dialogico. La metafora della “seconda navigazione” rimanda al V libro dell’Odissea, in cui Odisseo rinuncia alla vita paradisiaca nell’isola di Calipso per tentare la traversata dell’abisso su una zattera e rag- giungere Itaca. In tutto il dialogo si trovano numerosi riferimenti all’Odissea: l’excursus autobiografico in cui Socrate definisce la propria filosofia può essere confrontato con i Discorsi di Odisseo alla corte del re Alcinoo. In …
Er?mos Aporos as the Paradigmatic Figure of Western (Thanato) Political Subject
2013
The originary figure of the Western political subject is neither the Aristotelian zōon politikon nor the Agambenian homo sacer but the Socratic erēmos aporos. Like the Agambenian homo sacer, the Socratic erēmos aporos is abandoned by his fellow citizens, not outside the polis but in the polis, being a refugee in his own city. He lives, as Callicles says of Socrates in Gorgias (486c), “in his city as an absolute outcast.” Moreover, like the Agambenian homo sacer, the Socratic erēmos aporos also lives in a state close to death—“in a state as close to death as possible,” as Socrates says of himself in Phaedo (67d). However, there is a decisive difference between the Agambenian homo sacer and …
In HCV-related liver cirrhosis, local pulse wave velocity increases and in decompensated patients correlates with poorer survival
2018
BackgroundCirrhotic cardiomyopathy (CCM) refers to cardiac dysfunction in patients with liver cirrhosis, in the absence of other known cardiac disease.MethodsControl group and patients diagnosed of liver cirrhosis without known cardiac disease or hepatocellular carcinoma were enrolled for this clinical observation study. Patients with diabetes mellitus, hypertension were excluded. Absolute global longitudinal strain, one-point carotid pulse wave velocity (one-point PWV) and various parameters were measured in resting status.ResultsThere were 29 participants in the control group and 80 patients in the liver cirrhosis group. 27.8% of cirrhotic patients presented with normal systolic but abnor…
Morphological and Postural Changes in the Foot during Pregnancy and Puerperium: A Longitudinal Study
2021
The aim of this study is to observe the morphological and postural changes to the foot that take place during pregnancy and the puerperium. Method: In this descriptive, observational, longitudinal study, we analysed 23 pregnant women, with particular attention to morphological and postural aspects of the foot, at three time points during and after pregnancy: in weeks 9–13 of gestation, weeks 32–35 of gestation and weeks 4–6 after delivery. The parameters considered were changes in foot length, the Foot Posture Index (FPI) and the Hernández Corvo Index, which were analysed using a pedigraph and taking into account the Body Mass Index (BMI). The same procedure was conducted in each review. Re…
Iedzīvotāju skaita samazināšanās un jauniešu emigrācija Latvijā un Lietuvā
2018
Maģistra darba mērķis ir aprakstīt un analizēt demogrāfiskās tendences iedzīvotāju migrācijā, novecošanā, populācijas sarukšanā, intelektuālā darbaspēka emigrācijā un izvērtēt šos kritērijus Lietuvā un Latvijā. Kādas ir dažādo demogrāfisko parādību definīcijas un to atšķirības un kā tās tiek pielietotas Lietuvā un Latvijā salīdzinājumā ar pārējo pasauli un Eiropas Savienību? Un kāda ir Lietuvas un Latvijas jaunatnes motivācija dzīvot, strādāt un veidot ģimenes savā dzimtenē? Ko veicina augsts negatīvās migrācijas, iedzīvotāju skaita samazināšanās un novecošanas rādītājs Lietuvā un Latvijā un kāpēc tas ir tik svarīgs jautājums? Darbā tiks analizēti notikumi no 90. gadu sākuma līdz mūsdienām …
Por el Regio Fisco, y Nicolas Meseguer, contra el Patron Francisco Lucano.
1707
Sig. A-D2 Signat al final: "Doct. Nicolas Bas". - Precedeix al tít. "Jesus, Maria, Joseph" Reclams. - Capital grav
Lumbriculus variegatus (Annelida) biological responses and sediment sequential extractions indicate ecotoxicity of lake sediments contaminated by bio…
2018
Abstract We assessed potential ecotoxicity of lake sediments affected by biomining effluents in northeastern Finland. Growth, reproduction and behavior of the sediment-dwelling oligochaete Lumbriculus variegatus (Muller 1774) were used as ecotoxicity endpoints. Standardized chronic bioassays were used for growth and reproduction, and acute and chronic tests with Multispecies Freshwater Biomonitor (MFB) for behavior assessments. Sequential extractions were used to characterize metal bioavailability and exposure conditions in the sediments, which indicated mining-induced contamination gradients of S, Cu, Ni and U and also bioavailability gradients of S and Ni. Among the ecotoxicity endpoints,…
Toxicity of Mining-Contaminated Lake Sediments to Lumbriculus variegatus
2021
AbstractBoreal lakes with soft water and low buffering capacity are susceptible to excess ion loading resulting from metal mining. The impact of two Finish mining sites in downstream lakes was assessed with a chronic sediment toxicity test using a laboratory-reared freshwater Lumbriculus variegatus (Oligochaeta). The test organisms were exposed to mining-contaminated natural lake sediments and hypolimnion water (HLW) or artificial freshwater (AFW) as overlying water in two independent experimental setups. In both test setups, growth and reproduction of L. variegatus were lower in sediments from the lakes receiving high amount of mining effluents from the mines nearby. In the biomining site,…
Docosahexaenoic acid inhibits cancer cell growth via p27Kip1, CDK2, ERK1/ERK2, and retinoblastoma phosphorylation
2006
Docosahexaenoic acid (DHA), a PUFA of the n-3 family, inhibited the growth of FM3A mouse mammary cancer cells by arresting their progression from the late-G(1) to the S phase of the cell cycle. DHA upregulated p27(Kip1) levels by inhibiting phosphorylation of mitogen-activated protein (MAP) kinases, i.e., ERK1/ERK2. Indeed, inhibition of ERK1/ERK2 phosphorylation by DHA, U0126 [chemical MAPK extracellularly signal-regulated kinase kinase (MEK) inhibitor], and MEK(SA) (cells expressing dominant negative constructs of MEK) resulted in the accumulation of p27(Kip1). MAP kinase (MAPK) inhibition by DHA did not increase p27(Kip1) mRNA levels. Rather, this fatty acid stabilized p27(Kip1) contents…
p42 MAPK phosphorylates 80 kDa MARCKS at Ser-113.
1996
Abstract It is demonstrated here that p42 MAPKinase (p42 MAPK) phosphorylates the M yristoylated A lanine- R ich C - K inase S ubstrate (MARCKS) at Ser-113. In permeabilised Swiss 3T3 cells activation of protein kinase C (PKC) leads to p42 MAPK activation, but only the protein kinase C sites in MARCKS become phosphorylated and not Ser-113. The mitogen platelet-derived growth factor (PDGF) elicits the same response. These results demonstrate that while Ser-113 is a substrate for p42 MAPK in vitro and can be phosphorylated in vivo as shown by Taniguchi et al. [(1994) J. Biol. Chem. 269, 18299–18302], its phosphorylation is not subject to acute regulation by p42 MAPK in Swiss 3T3 cells.