Search results for "Rating"

Eine Bemerkung zur Frage der Verwendung Lagrangescher Koordinaten in der Physik nichtlinearer Schwingungen

1958

For the Cartesian coordinates of the elements of a vibrating string, which are introduced as functions of time and a parameter (similar to the Lagrangean method in hydrodynamics), a general, non-linear system of differential equations is offered. The behaviour of the freely vibrating string corresponding to this system agrees, approximately, with the behaviour of a string put in motion in a certain way, which string, if moving freely, would act according to the linear differential equation of the elementary theory.

Novel cleavable cell-penetrating peptide-drug conjugates: synthesis and characterization

2014

We report the first drug conjugate with a negatively charged amphipathic cell-penetrating peptide. Furthermore, we compare two different doxorubicin cell-penetrating peptide conjugates, which are both unique in their properties, due to their net charge at physiological pH, namely the positively charged octaarginine and the negatively charged proline-rich amphipathic peptide. These conjugates were prepared exploiting a novel heterobifunctional crosslinker to join the N-terminal cysteine residue of the peptides with the aliphatic ketone of doxorubicin. This small linker contains an activated thiol as well as aminooxy functionality, capable of generating a stable oxime bond with the C-13 carbo…

Comparison of Paroxetine and Maprotiline in Minor Depression

1994

Whilst the efficacy of paroxetine has been demonstrated in MDD, its clinical utility in minor depression has not been established. This study assesses the antidepressant efficacy of paroxetine in patients meeting RDC criteria for minor depression. All patients scored 13 points on the 17-item Hamilton Depression Rating Scale (HAMD) at baseline. After a 3 day washout period, patients were randomised to receive paroxetine 20–40mg/day or maprotiline 100-150mg/day, dose being titrated according to clinical response after 3 weeks treatment at the lower doses. Assessments conducted at baseline (day 0) and at weekly intervals for 6 weeks included the 17-item HAMD, the Montgomery-Asberg Depression R…

Measures of the efficacy of psychotropic drugs in acute treatment: the current status of their validity

1992

Supplementary optical phase transition in photorefractive coherent oscillator

2001

The semilinear photorefractive coherent oscillator with two counterpropagating pump waves may exhibit two optical phase transitions: one from a disordered state of wide-angle photorefractive scattering into a high-ordered state with the immobile photorefractive grating and the other one from the state with immobile grating into the state with two moving photorefractive gratings. We show, both experimentally and from calculations, that two these phase transitions are the second-order phase transitions.

A comparison of spreading and motility behaviour of 8701-BC breast carcinoma cells on type I, I-trimer and type V collagen substrata. Evidence for a …

1991

Ductal infiltrating carcinoma (d.i.c.) of human breast is a highly invasive neoplasm characterized by enhanced deposition of collagen. Paradoxically, enhanced collagen deposition is not correlated with inhibition of the migration of tumour cells into the host tissue. d.i.c. is characterized by the reappearance of ‘embryonic’ type I-trimer collagen and an increase in type V collagen content in the matrix. The effects of these two collagen types were compared with type I collagen as culture substrata on the spreading pattern, cytoskeletal organization and motile behaviour of 8701-BC breast carcinoma cells using rhodamine-phalloidin staining, a DNAase I-competition assay, scanning electron mic…

Submicrometer in-plane integrated surface plasmon cavities.

2007

International audience; The optical properties of in-plane integrated surface plasmon polariton (SPP) cavities comprised of a thin film area sandwiched between two one-dimensional Bragg SPP mirrors are investigated numerically and experimentally. We discuss the resonance condition of these cavities, and we analyze in details the physical origin of the dispersion of this resonance. On the basis of numerical results, we show that in-plane SPP cavities can be used to achieve local SPP field enhancement and antireflecting SPP layers. The numerical results are compared to near-field optical images recorded by operating a photon scanning tunneling microscope. From the near-field images recorded o…

Real-time and low-cost sensing technique based on photonic bandgap structures

2011

[EN] A technique for the development of low-cost and high-sensitivity photonic biosensing devices is proposed and experimentally demonstrated. In this technique, a photonic bandgap structure is used as transducer, but its readout is performed by simply using a broadband source, an optical filter, and a power meter, without the need of obtaining the transmission spectrum of the structure; thus, a really low-cost system and real-time results are achieved. Experimental results show that it is possible to detect very low refractive index variations, achieving a detection limit below 2 x 10(-6) refractive index units using this low-cost measuring technique. (C) 2011 Optical Society of America[

APDs as single-photon detectors for visible and near-infrared wavelengths down to Hz rates

2012

For the SPECTRAP experiment at GSI, Germany, detectors with Single-Photon counting capability in the visible and near-infrared regime are required. For the wavelength region up to 1100 nm we investigate the performance of 2x2 mm^2 avalanche photo diodes (APDs) of type S0223 manufactured by Radiation Monitoring Devices. To minimize thermal noise, the APDs are cooled to approximately -170 deg. C using liquid nitrogen. By operating the diodes close to the breakdown voltage it is possible to achieve relative gains in excess of 2x10^4. Custom-made low noise preamplifiers are used to read out the devices. The measurements presented in this paper have been obtained at a relative gain of 2.2x10^4. …

Variable delay line for phased-array antenna based on a chirped fiber grating

2000

We present a theoretical and experimental analysis of the performance of phased-array antennas steered by a single chirped fiber grating. Two approaches consisting of conventional and single-sideband (SSB) modulation techniques of the optical signal are presented in order to compare their performance and suitability for beamforming applications in microwave antennas. By using a 40-cm-long chirped grating, we measure the phase and amplitude response and calculate the corresponding radiation patterns to demonstrate wide-band operation and continuous spatial scanning properties of both configurations. SSB modulation Is presented as a real alternative to the first one offering broader operation…