Search results for "Ray"
showing 10 items of 8009 documents
In Silico Analysis of Microarray-Based Gene Expression Profiles Predicts Tumor Cell Response to Withanolides
2012
Withania somnifera (L.) Dunal (Indian ginseng, winter cherry, Solanaceae) is widely used in traditional medicine. Roots are either chewed or used to prepare beverages (aqueous decocts). The major secondary metabolites of Withania somnifera are the withanolides, which are C-28-steroidal lactone triterpenoids. Withania somnifera extracts exert chemopreventive and anticancer activities in vitro and in vivo. The aims of the present in silico study were, firstly, to investigate whether tumor cells develop cross-resistance between standard anticancer drugs and withanolides and, secondly, to elucidate the molecular determinants of sensitivity and resistance of tumor cells towards withanolides. Usi…
Integración de la genómica en la modelización de los tumores neuroblásticos = Integration of genomics in neuroblastic tumors modeling
2015
*Introducción: El neuroblastoma es un tumor maligno embrionario del sistema nervioso simpático con una gran heterogeneidad en la presentación clínica, morfológica y genética y en otras características biológicas. La estratificación de grupos de riesgo pretratamiento se basa en los siguientes factores: edad, estadio, histopatológica del tumor, estado del oncogén MYCN, integridad del brazo cromosómico 11q y ploidía. Por otra parte, los cambios numéricos y estructurales detectados en el perfil genético se han incluido recientemente en la estratificación terapéutica de los pacientes con bajo riesgo a recaer o morir. El amplio espectro clínico de la enfermedad va desde pacientes con neuroblastom…
Search for Gravitational Waves Associated with Gamma-Ray Bursts Detected by Fermi and Swift during the LIGO-Virgo Run O3a
2022
Abbott, R., et al. (LIGO and VIRGO Collaboration)
GW170817: Observation of Gravitational Waves from a Binary Neutron Star Inspiral
2017
On August 17, 2017 at 12-41:04 UTC the Advanced LIGO and Advanced Virgo gravitational-wave detectors made their first observation of a binary neutron star inspiral. The signal, GW170817, was detected with a combined signal-to-noise ratio of 32.4 and a false-alarm-rate estimate of less than one per 8.0×104 years. We infer the component masses of the binary to be between 0.86 and 2.26 M, in agreement with masses of known neutron stars. Restricting the component spins to the range inferred in binary neutron stars, we find the component masses to be in the range 1.17-1.60 M, with the total mass of the system 2.74-0.01+0.04M. The source was localized within a sky region of 28 deg2 (90% probabili…
New orbital ephemerides for the dipping source 4U 1323-619: Constraining the distance to the source
2016
4U 1323-619 is a low mass X-ray binary system that shows type I X-ray bursts and dips. The most accurate estimation of the orbital period is 2.941923(36) hrs and a distance from the source that is lower than 11 kpc has been proposed. We aim to obtain the orbital ephemeris, the orbital period of the system, as well as its derivative to compare the observed luminosity with that predicted by the theory of secular evolution. We took the advantage of about 26 years of X-ray data and grouped the selected observations when close in time. We folded the light curves and used the timing technique, obtaining 12 dip arrival times. We fit the delays of the dip arrival times both with a linear and a quad…
Timing an Accreting Millisecond Pulsar: Measuring the Accretion Torque in IGR J00291+5934
2006
We performed a timing analysis of the fastest accreting millisecond pulsar IGR J00291+5934 using RXTE data taken during the outburst of December 2004. We corrected the arrival times of all the events for the orbital (Doppler) effects and performed a timing analysis of the resulting phase delays. In this way we have the possibility to study, for the first time in this class of sources, the spin-up of a millisecond pulsar as a consequence of accretion torques during the X-ray outburst. The accretion torque gives us for the first time an independent estimate of the mass accretion rate onto the neutron star, which can be compared with the observed X-ray luminosity. We also report a revised valu…
It takes time to see the menu from the body: an experiment on stable isotope composition in freshwater crayfishes
2015
For many applications and ecological studies in which wild individuals are brought to laboratory it would be essential to know accurately how fast novel diet is reflected in composition of different tissues. To study the effects of two different diets on the stable isotope composition of freshwater crayfish muscle and hemolymph, we conducted a three month experiment on noble crayfish (Astacus astacus) and signal crayfish (Pacifastacus leniusculus) by feeding them sweet corn (Zea mays) or Baltic herring (Clupea harengus membras) as novel food. During the experiment, the crayfish were given 0.4 g of selected food daily and the amount consumed was recorded. The samples for the stable isotope a…
Studies of transition-edge sensor physics : thermal models and noise
2011
This thesis focuses on studying the noise in transition-edge sensors (TES). More specifically, the aim is to find an explanation for the observed excess noise that is limiting their performance and has been troubling the TES field in recent years. Several theories have been put forth but a definitive answer is still missing. In the early stages of this thesis work a novel theory was presented for the noise in a special TES geometry. In our theory the excess noise is caused by correlated fluctuations of superconductivity at the phase boundary between normal and superconducting states. Data from more recent experiments does not give solid support for the theory and in this thesis the validity…
Phase-delayed laser diode array allows ultrasonic guided wave mode selection and tuning
2013
Selecting and tuning modes are useful in ultrasonic guided wave non-destructive testing (NDT) since certain modes at various center frequencies are sensitive to specific types of defects. Ideally one should be able to select both the mode and the center frequency of the launched waves. We demonstrated that an affordable laser diode array can selectively launch either the S0 or A0 ultrasonic wave mode at a chosen center frequency into a polymer plate. A fiber-coupled diode array (4 elements) illuminated a 2 mm thick acrylic plate. A predetermined time delay matching the selected mode and frequency was employed between the output of the elements. The generated ultrasound was detected by a 215…
Identification and quantification of phosphatidylcholines containing very long chain polyunsaturated fatty acid (VLC-PUFA) in bovine and human retina…
2010
The retina is one of the vertebrate tissues with the highest content in polyunsaturated fatty acids (PUFA). A large proportion of the retinal glycerophospholipids, especially those found in photoreceptor membranes, are dipolyunsaturated molecular species. Among them, dipolyunsaturated phosphatidylcholine molecular species are known to contain very long chain polyunsaturated fatty acids (VLC-PUFA) from the n-3 and n-6 series and having 24 to 36 carbon atoms (C24 to C36) and four to six double bonds. Recent interest in the role of VLC-PUFA arose from the findings that a protein named ELOngation of Very Long chain fatty acids 4 (ELOVL4) is involved in their biosynthesis and that mutations in E…