Search results for "Reaction"

showing 10 items of 6134 documents

Rare-earth metal bis(tetramethylaluminate) complexes supported by a sterically crowded triazenido ligand

2010

Complexes [NNN]Ln(AlMe(4))(2) (Ln = Y, La, Nd, Lu) bearing the sterically demanding aryl-substituted triazenido ligand [(Tph)(2)N(3)] (Tph = [2-(2,4,6-iPr(3)C(6)H(2))C(6)H(4)]) can be obtained from homoleptic complexes Ln(AlMe(4))(3) in moderate yields, both via protonolysis with [(Tph)(2)N(3)]H and a salt metathesis reaction pathway utilizing [(Tph)(2)N(3)]K. In the solid state the Y and Lu derivatives are isostructural, with both tetramethylaluminate groups coordinated in an eta(2) fashion, while one of the [AlMe(4)] ligands of the Nd derivative features a distorted eta(2) coordination mode. Due to the high affinity of the triazenido ligand toward the more Lewis-acidic and harder aluminiu…

Steric effectsChemistryLigandStereochemistryMedicinal chemistryInorganic ChemistryMetalchemistry.chemical_compoundvisual_artvisual_art.visual_art_mediumSalt metathesis reactionRedistribution (chemistry)ProtonolysisIsostructuralHomolepticDalton Transactions
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Rearrangement products of 3-methanesulfonyl-N-methyl-N-nitroaniline.

2003

Two isomeric products (C 8 H 10 N 2 O 4 S) of the rearrangement of 3-methanesulfonyl-N-methyl-N-nitroaniline have been investigated, viz. 3-methanesulfonyl-N-methyl-2-nitroaniline, which was the main product of the rearrangement, and 5-methanesulfonyl-N-methyl-2-nitroaniline. In both molecules, the aromatic rings are appreciably deformed towards ortho-quinonoidal geometry by electronic and steric interactions. The crystal structure is stabilized, in both cases, by weak C-H...O hydrogen bonds.

Steric effectsChemistryStereochemistryHydrogen bondMoleculeAromaticityGeneral MedicineCrystal structureSigmatropic reactionMedicinal chemistryGeneral Biochemistry Genetics and Molecular BiologyNitroanilineCope rearrangementActa crystallographica. Section C, Crystal structure communications
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Mononuclear tungsten(VI) complexes with bis(phenolato) ligands: syntheses, characterisations and activity in ROMP reaction

2002

The reaction of bulky ligand precursor 2,2?-methylenebis(4-methyl-6-tert -butylphenol) (H2mbp) or 2,2?-ethylidenebis(4,6-di-tert butylphenol) (H2ebp) with trisdiolatotungsten(VI) complex [W(eg)3] 1 (eg � /ethanediolate dianion) provides heteroleptic complexes [W(mbp)(eg)2] 2 or [W(ebp)(eg)2] 3, respectively. Sterically less hindered 2,2?-dihydroxy-1,1?-dinaphtylmethane (H2dinap) forms heteroleptic disubstituted complex [W(dinap)2(eg)] 4. The X-ray crystal structure determinations confirmed that the isolated compounds are made of monomeric tris(diolato)tungsten(VI) molecules in which the central tungsten atom is bonded to six oxygen atoms forming a distorted octahedral coordination sphere ar…

Steric effectsCoordination sphereChemistryLigandROMPCrystal structurePhotochemistryMedicinal chemistryInorganic Chemistrychemistry.chemical_compoundMaterials ChemistrySalt metathesis reactionMoleculePhysical and Theoretical ChemistryNorbornenePolyhedron
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(E)-2-{[1-(3,11-Dimethyl-4-methylene-10-oxo-1-phenyl-4,5,10,11-tetrahydro-1H-benzo[b]pyrazolo[3,4-f][1,5]diazocin-5-yl)ethylidene]amino}-N-methyl-N-(…

2013

The central eight-membered ring of the title compound, C40H36N8O2, deviates from the ideal boat conformation because the bond between the exo-ethylene group and the adjacent N atom is twisted by 60.0 (4)° due to steric hindrance. Its adjacent benzene and pyrazole rings are oriented almost perpendicular to each other, making a dihedral angle of 85.8 (3)°. In the crystal, the molecules are linked by C(ar)—H...O hydrogen bonds, generating a three-dimensional network.

Steric effectsCrystallographyHydrogen bondCyclohexane conformationGeneral ChemistryDihedral anglePyrazoleCondensed Matter PhysicsRing (chemistry)Settore CHIM/08 - Chimica FarmaceuticaOrganic PapersMedicinal chemistrychemistry.chemical_compoundchemistryDiazocine derivative X-ray structureQD901-999General Materials ScienceDiazoEne reactionActa Crystallographica Section E Structure Reports Online
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Unveiling the Ionic Diels-Alder Reactions within the Molecular Electron Density Theory

2021

The ionic Diels–Alder (I-DA) reactions of a series of six iminium cations with cyclopentadiene have been studied within the Molecular Electron Density Theory (MEDT). The superelectrophilic character of iminium cations, ω &gt

Steric effectsCyclopentadienePharmaceutical ScienceIonic bonding010402 general chemistry01 natural sciencesArticleAnalytical Chemistrychemistry.chemical_compoundQD241-441Computational chemistryDrug Discoveryionic Diels–Alder reactionsReactivity (chemistry)Physical and Theoretical Chemistryorganic_chemistry010405 organic chemistryChemistryOrganic ChemistrySolvationCationic polymerizationMolecular Electron Density TheoryIminiumiminium cationsElectron localization function3. Good health0104 chemical sciencesChemistry (miscellaneous)asynchronicityglobal electron density transfersuperelectrophilesMolecular Medicine
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An unprecedented, bridged dihydrogen complex of a cofacial metallodiporphyrin and its relevance to the bimolecular reductive elimination of hydrogen

1990

Recently, the authors characterized the first metalloporphyrin dihydrogen complex, Os(OEP)(H{sub 2}), and proposed that a similar ruthenium porphyrin dihydrogen complex, Ru(OEP)(H{sub 2}), is involved as an intermediate in the catalytic H/D isotopic exchange between water and hydrogen. They now report that treatment of a metal-metal-bonded cofacial ruthenium porphyrin dimer with a sterically bulky ligand in the presence of hydrogen gas has yielded the first known complex containing a dihydrogen ligand bound between two metals. Such a bridged dihydrogen complex is proposed as an intermediate in the bimolecular elimination of dihydrogen from two metalloporphyrin hydrides.

Steric effectsLigandDimerchemistry.chemical_elementGeneral ChemistryReaction intermediateBiochemistryPorphyrinMedicinal chemistryCatalysisReductive eliminationRutheniumchemistry.chemical_compoundColloid and Surface ChemistrychemistryDihydrogen complexJournal of the American Chemical Society
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The role of fluorine in the stereoselective tandem Aza-Michael addition to acrylamide acceptors: An experimental and theoretical mechanistic study

2007

Aza-Michael additions of alpha-amino esters to fluorinated acceptors take place in a highly stereoselective manner, to give partially modified Psi-[NHCH2]retropeptides incorporating a hydrolytically stable trifluoroalanine mimic. The reaction mechanism has been investigated experimentally and theoretically, in order to explain the effect of the trifluoromethyl group on the reactivity and the origins of the experimentally observed stereocontrol. The reaction is a two-step process, involving a tandem aza-Michael addition followed by a stereoselective hydrogen transfer. Both steps are base-catalyzed. The high level of stereocontrol is the result of a combination of electrostatic interactions a…

Steric effectsModels MolecularReaction mechanismMagnetic Resonance SpectroscopyStereochemistrychemistry.chemical_elementStereoisomerismCatalysisMass Spectrometrychemistry.chemical_compoundComputational chemistrycalculationsReactivity (chemistry)density functionalAcrylamideTrifluoromethyldiastereoselectivity fluorine chemistryOrganic ChemistryStereoisomerismGeneral ChemistryFluorinechemistryFluorineMichael reactionpeptidesStereoselectivityMichael reaction
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A study of the diels-alder reaction of 3-oxabicyclo[3.3.0]oct-1(5)-ene-2,4-dione with cyclopentadiene and some related dienes

1984

Abstract The reaction of 3-oxabicyclo[3.3.0]oct-l(5)ene-2,4-dione, 2, with cyclopentadiene, 3, 5,5-diethoxycyclopentadiene, 4, and 6,6-dimethylfulvene, 5, is studied. Reaction of 2 and 3 yields the expected endo-adduct, while reaction of 2 and 5 gives a mixture of the endo- and exo-adducts whose ratio is slightly dependent on the reaction conditions. Attractive electrostatic interactions in the transition state leading to the exo-adduct can explain the absence of endo stereoselectivity in the last reaction. Steric factors seem to be responsible for the absence of reaction between 2 and 4. The analysis of the 13C NMR spectra of these adducts and some derived compounds confirms the tentative …

Steric effectsOrder of reactionCyclopentadieneBicyclic moleculeStereochemistryOrganic ChemistryBiochemistryMedicinal chemistryElimination reactionchemistry.chemical_compoundchemistryDrug DiscoveryStereoselectivityEne reactionDiels–Alder reactionTetrahedron
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An ab initio study of the enolboration of 3-pentanone mediated by boron monochlorides L2BCl

2001

Abstract Using ab initio methods at the HF/6-31G∗∗ level, we have studied the mechanism of the enolboration of 3-pentanone mediated by boron monochlorides L2BCl (L=H, methyl and isopropyl) and trimethyl amine. The size of the L group has been found to have a decisive influence on the configuration (E or Z) of the formed boron enolate. Thus, whereas our calculations predict that dimethylboron chloride yields the Z enolate with high stereoselectivity, diisopropylboron chloride is found to yield predominantly the E enolate. The difference in behavior is due mainly to steric features related to the conformational bias of the respective ketone–boron chloride complexes formed reversibly in the fi…

Steric effectsOrganic ChemistryAb initiochemistry.chemical_elementBiochemistryChlorideAldol reactionchemistryAb initio quantum chemistry methodsComputational chemistryDrug DiscoverymedicineStereoselectivityBoronIsopropylmedicine.drugTetrahedron
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Introducing a 1,1-diphenylethylene analogue for vinylpyridine: anionic copolymerisation of 3-(1-phenylvinyl)pyridine (m-PyPE)

2021

3-(1-Phenylvinyl)pyridine (m-PyPE), prepared by Wittig reaction from the readily available 3-benzoylpyridine, represents a structural analog of 1,1-diphenylethylene (DPE), one phenyl group being replaced by pyridine. The suitability of m-PyPE for the copolymerisation with vinylpyridine is reflected by the 13C NMR shifts of the β-carbon of 2-vinylpyridine (2-VP; 118.32 ppm) and m-PyPE (115.83 ppm, measured in CDCl3), which possess predictive character for carbanionic copolymerisation. In analogy to DPE and its manifold reported derivatives, carbanionic homopolymerisation of m-PyPE was not possible, due to its steric bulk. Copolymers of 2-VP and m-PyPE with varied composition have been synthe…

Steric effectsPolymers and PlasticsOrganic ChemistryBioengineeringBiochemistrychemistry.chemical_compoundMonomerchemistryPolymer chemistryWittig reactionPyridineCopolymerPhenyl groupGlass transitionStructural analogPolymer Chemistry
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