Search results for "Reaction"

Methylprednisolone-induced hepatotoxicity in a 16-year-old girl with multiple sclerosis.

2018

Multiple sclerosis (MS) is a chronic inflammatory disease with demyelination of the central nervous system. High-dosage corticosteroids are the first-line therapy in the acute relapsing of MS. We report a case of severe high-dose methylprednisolone-induced acute hepatitis in a patient with a new diagnosis of MS. A 16-year-old girl was admitted for urticaria, angioedema, nausea and vomiting a month later she had been diagnosed with MS and treated with high-dosage methylprednisolone. Laboratory investigations showed hepatic insufficiency with grossly elevated liver enzymes. A liver biopsy showed focal centrilobular hepatocyte necrosis with interface hepatitis. Methylprednisolone-induced hepat…

Testing the nature of the Λ(1520)-resonance in proton-induced production

2006

The $\Lambda(1520)$ resonance has been recently studied in a unitarized coupled channel formalism with $\pi\Sigma(1385)$, $K\Xi(1530)$, $\bar{K}N$ and $\pi\Sigma$ as constituents blocks. We provide a theoretical study of the predictions of this model in physical observables of the $pp\to pK^+K^-p$ and $pp\to pK^+\pi^0\pi^0\Lambda$ reactions. In particular, we show that the ratio between the $\pi^0\pi^0\Lambda$ and $K^-p$ mass distributions can provide valuable information on the ratio of the couplings of the $\Lambda(1520)$ resonance to $\pi\Sigma(1385)$ and $\bar{K}N$ that the theory predicts. Calculations are done for energies which are accessible in an experimental facility like COSY at …

Synthesis, NMR spectral and structural studies on mixed ligand complexes of Pd(II) dithiocarbamates: First structural report on palladium(II) dithioc…

2016

Abstract Three new mixed ligand complexes of palladium(II) dithiocarbamates; [Pd(4-dpmpzdtc)(PPh3)(SCN)] (1), [Pd(4-dpmpzdtc)(PPh3)Cl] (2) and [Pd(bzbudtc)(PPh3)Cl] (3), (where, 4-dpmpzdtc = 4-(diphenylmethyl)piperazinecarbodithioato anion, bzbudtc = N-benzyl-N-butyldithiocarbamato anion and PPh3 = triphenylphosphine) have been synthesized from their respective parent dithiocarbamates by ligand exchange reactions and characterized by IR and NMR (1H, 13C and 31P) spectroscopy. IR and NMR spectral data support the isobidentate coordination of the dithiocarbamate ligands in all complexes (1–3) in solid and in solution, respectively. Single crystal diffraction analysis of complexes 1–3 evidence…

Open-source QCD analysis of nuclear parton distribution functions at NLO and NNLO

2019

We present new sets of nuclear parton distribution functions (nPDFs) at next-to-leading order (NLO) and next-to-next-to-leading order (NNLO). Our analyses are based on deeply inelastic scattering data with charged-lepton and neutrino beams on nuclear targets. In addition, a set of proton baseline PDFs is fitted within the same framework with the same theoretical assumptions. The results of this global QCD analysis are compared to existing nPDF sets and to the fitted cross sections. Also, the uncertainties resulting from the limited constraining power of the included experimental data are presented. The published work is based on an open-source tool, xFitter, which has been modified to be ap…

Mukaiyama-Michael reactions with α-substituted acroleins - a useful tool for the synthesis of the pectenotoxins and other natural product targets

2013

Synthesis and Molecular Modeling Studies of Derivatives of a Highly Potent Peptidomimetic Vinyl Ester as Falcipain-2 Inhibitors

2012

Herein we report the synthesis of a set of constrained peptidomimetics endowed with an electrophilic vinyl ester warhead and structurally related to a previously identified lead compound, a potent and irreversible inhibitor of falcipain-2 (FP-2). FP-2 is the main hemoglobinase of the malaria parasite P. falciparum. The new compounds were evaluated for their inhibition against FP-2, and the results were rationalized on the basis of docking experiments. These studies underscore the pivotal role of both the ester function at the P1' site and the trifluoromethyl group of the P3 side chain in determining the correct orientation of the Michael acceptor warhead in the catalytic site, and as a cons…

THE ROLE OF THE CLINICAL PHARMACIST IN THE MANAGEMENT OF ANTIRETROVIRAL THERAPY

2020

Over the last few years, the Hospital Pharmacy has developed in an excellent way in Europe, proposing in many countries the clinical pharmacist as a new professional figure, and adapting its responsibilities to national health systems. The purpose of this study is to evaluate and promote the prescriptive appropriateness through the close collaboration between the pharmacist and the medical team. The aspect of the dispensation of antiretroviral therapy was deepened by providing useful information to the patient on the possible undesired effects and interactions due to the polypharmacy, on the correct way of storing the drugs, and on the importance of the regularity of the polypharmacy intake…

Conformational-Dependent Photodissociation of Glycolic Acid in an Argon Matrix

2023

Ultraviolet-induced photodissociation and photo-isomerization of the three most stable conformers (SSC, GAC, and AAT) of glycolic acid are investigated in a low-temperature solid argon matrix using FTIR spectroscopy and employing laser radiation with wavelengths of 212 nm, 226 nm, and 230 nm. The present work broadens the wavelength range of photochemical studies of glycolic acid, thus extending the understanding of the overall photochemistry of the compound. The proposed kinetic model for the photodissociation of glycolic acid proceeds from the lowest energy conformer (SSC). The model suggests that ultraviolet light induces isomerization only between the SSC and GAC conformers and between …

Majorana parameters of the interacting boson model of nuclear structure and their implication for 0νββ decay

2021

Nucleon dissociation and incoherent J/ψ photoproduction on nuclei in ion ultraperipheral collisions at the CERN Large Hadron Collider

2019

Using the general notion of cross section fluctuations in hadron-nucleus scattering at high energies, we derive an expression for the cross section of incoherent J / ψ photoproduction on heavy nuclei d σ γ A → J / ψ Y / d t , which includes both elastic d σ γ p → J / ψ p / d t and proton-dissociation d σ γ p → J / ψ Y / d t photoproduction on target nucleons. We find that, with good accuracy, d σ γ A → J / ψ Y / d t can be expressed as a product of the sum of the d σ γ p → J / ψ p / d t and d σ γ p → J / ψ Y / d t cross sections, which have been measured at HERA, and the common nuclear shadowing factor, which is calculated using the leading twist nuclear shadowing model. Our prediction for …