Search results for "Reactive"
showing 10 items of 1469 documents
Dryofragin, a phloroglucinol derivative, induces apoptosis in human breast cancer MCF-7 cells through ROS-mediated mitochondrial pathway
2012
Dryofragin is a phloroglucinol derivative extracted from Dryopteris fragrans (L.) Schott. In this study, the anticancer activity of dryofragin on human breast cancer MCF-7 cells was investigated. Dryofragin inhibited the growth of MCF-7 cells in a time and concentration-dependent manner. The cell viability was measured using MTT assay. After treatment with dryofragin for 72, 48 and 24 h, the IC₅₀ values were 27.26, 37.51 and 76.10 μM, respectively. Further analyses of DNA fragmentation and Annexin V-PI double-labeling indicated an induction of apoptosis. Dryofragin-treatment MCF-7 cells had a significantly accumulation of reactive oxygen species (ROS), as well as an increased percentage of …
The therapeutic modulation of atherogenic dyslipidemia and inflammatory markers in the metabolic syndrome: what is the clinical relevance?
2008
The metabolic syndrome consists of a constellation of clinical and biochemical risk factors that cluster together and heighten the risk for atherogenesis, cardiovascular diseases, and diabetes. Established risk cardiovascular factors like hypertension, atherogenic dyslipidaemia, and glucose intolerance occur in the setting of insulin resistance and central adiposity, with genetic and environmental influences modulating the ultimate risk. Chronic insults to the endothelium take its toll in the form of silent as well as clinically evident cardiovascular events. The cellular and vascular accompaniments have shed some light into the underlying pathophysiology. Heightened, low-grade inflammatory…
Polynitroxylated hemoglobin-based oxygen carrier: inhibition of free radical-induced microcirculatory dysfunction.
1999
Reactive oxygen species have been identified as key mediators of leukocyte/endothelial cell interaction under various pathological conditions and diseases such as ischemia/reperfusion injury, inflammation, and after exposure to cigarette smoke. Consequently, antioxidants have been shown to successfully prevent the sequelae of these conditions, ranging from tissue infarction to atherogenesis. In this study we investigated whether, via its established superoxide dismutase-like activity, a novel polynitroxyl hemoglobin-based oxygen carrier (PNH), could affect the stimulation of leukocyte rolling and adhesion to endothelial cells in response to cigarette smoke. Using the dorsal skin fold chambe…
Hypothalamic glucose sensing : mitochondrial dynamic involument in reactive oxygen species signaling
2011
Energetic homeostasis results in the balance between energy intake and expenditure. The hypothalamus plays an important role in the regulation of both energetic metabolism and food intake in sensing hormonal and metabolic signals. For instance, changes in hypothalamic glucose level modulate food intake and insulin secretion. We have previously found that 1) increased hypothalamic glucose level triggers production of mitochondrial reactive oxygen species (mROS) from the electron transport chain; 2) hypothalamic mROS production is involved in glucose homeostasis and food intake control. The molecular mechanisms involved in glucose-induced hypothalamic mROS production are still unknown. Mitoch…
Thermodynamics, transport phenomena, and electrochemistry of external field-assisted nonthermal food technologies
2017
Interest in the development and adoption of nonthermal technologies is burgeoning within the food and bioprocess industry, the associated research community, and among the consumers. This is evident from not only the success of some innovative nonthermal technologies at industrial scale, but also from the increasing number of publications dealing with these topics, a growing demand for foods processed by nonthermal technologies and use of natural ingredients. A notable feature of the nonthermal technologies such as cold plasma, electrohydrodynamic processing, pulsed electric fields, and ultrasound is the involvement of external fields, either electric or sound. Therefore, it merits to study…
A GRASP algorithm for the container stowage slot planning problem
2016
This work presents a generalization of the Slot Planning Problem which raises when the liner shipping industry needs to plan the placement of containers within a vessel (stowage planning). State-of-the-art stowage planning relies on a heuristic decomposition where containers are first distributed in clusters along the vessel. For each of those clusters a specific position for each container must be found. Compared to previous studies, we have introduced two new features: the explicit handling of rolled out containers and the inclusion of separations rules for dangerous cargo. We present a novel integer programming formulation and a Greedy Randomized Adaptive Search Procedure (GRASP) to solv…
The metrological characterization of the static meters for reactive energy in the presence of harmonic distortion
2007
For the electricity metering for billing purposes in distribution systems, the static meters are substituting the traditional inductive meters. Thus, the evaluation of the performances of such equipments is required, also in the presence of disturbances affecting the power systems. With respect to this, this paper analyzes the main aspects related to the metrological characterization of the static meters for reactive energy in the presence of harmonic distortion. Particular attention is given to the reference standard meters, that are not considered by the actual in-force Standards. The analysis is supported by several experimental tests.
Static meters for the reactive energy in the presence of harmonics: an experimental metrological characterization
2009
Electricity metering plays a crucial role for all the commercial transactions on the energy market. Thus, an accurate evaluation of the performance of the electricity metering equipment is required not only in the reference operating conditions but also in the presence of disturbances affecting the power systems. As regards this matter, this paper analyzes the main aspects related to the metrological characterization of the static meters for the reactive energy in the presence of harmonic distortion. Attention is focused not only to the meters covered by the current standards but also to the meters of better accuracy and to the reference standard meters. The analysis is supported by several…
A model for reactive power tracing by addition of fictitious nodal injections
2012
Abstract This paper proposes an efficient solution to the problem of reactive power flow tracing in electrical transmission networks. For such systems, the tracing techniques used for active power flows cannot be used straightforwardly, due to reactive power variations induced by the line reactances, these variations often being comparable to the powers delivered to the loads. In other words, as is well known, in transmission systems the reactive flows are strongly influenced by the inductive and capacitive effects of the network, making the tracing of power flow and allocation of losses more critical. In this paper, after discussing some methodological aspects, an approach based on the use…
Power quality effects on the measurement of reactive power in three-phase power systems in the light of the IEEE Standard 1459–2000.
2007
Reactive power is a very important quantity in electric power systems since it affects the efficiency of these systems. Also, capacitive loads can produce over-voltages in electric transformers by Ferranti effect, which produces bad power quality, so it is necessary to measure the reactive power correctly. In this paper reactive phenomena in three-phase power systems with unbalanced voltages are expressed and measured in the light of the IEEE Std 1459-2000. For analyzing the reactive phenomena the positive-sequence fundamental frequency instantaneous reactive power is used. By comparing the expressions of this instantaneous power in three-phase systems with unbalanced voltages with those co…