Search results for "Reference"

Determining a healthy reference range and factors potentially influencing PRO-C3 – A biomarker of liver fibrosis

2021

Background & Aims Progressive fibrosis has been identified as the major predictor of mortality in patients with non-alcoholic fatty liver disease (NAFLD). Several biomarkers are currently being evaluated for their ability to substitute the liver biopsy as the reference standard. Recent clinical studies in NAFLD/NASH patients support the utility of PRO-C3, a marker of type III collagen formation, as a marker for the degree of fibrosis, disease activity, and effect of treatment. Here we establish the healthy reference range, optimal sample handling conditions for both short- and long-term serum storage, and robustness for the PRO-C3 assay. Methods PRO-C3 was measured in 269 healthy volunteers…

Effect of two xeno-hormones, genistein and vinclozolin on development and exocrines and endocrines functions of submandibular salivary glands of Wist…

2012

The salivary glands are mixed glands: saliva (exocrine product) is involved inmaintaining oral homeostasis whereas endocrine secretions (eg growth factors) have aphysiological role (gametogenesis, osteogenesis, hypertension ..). In mammals, they displaysexual dimorphism suggesting a possible susceptibility to xeno-hormones.This manuscript presents the action of genistein (phytoestrogen) and/or vinclozolin (antiandrogenic)on the submandibular gland (SM) rats when performing an early exposure via themother (pregnancy, lactation) or an exposure during the growth period (from weaning toadulthood). The SM glands, collected at immature and young adult ages, have been analyzedaccording histologica…

Cross-reinstatement by cocaine and amphetamine of morphine-induced place preference in mice

2005

The cross-reinstatement by psychostimulants of a conditioned place preference (CPP) induced by morphine was evaluated in mice. In Experiment 1, we examined the effects of a single dose of cocaine and amphetamine on a previously extinguished morphine CPP. After acquisition of CPP induced by morphine (40 mg/kg), animals underwent daily extinction sessions of 15 min duration until the CPP was extinguished. Subsequently, animals received a non-contingent injection of cocaine (25 mg/kg) or amphetamine (4 mg/kg), which produced the reinstatement of the extinguished morphine-induced CPP. In Experiment 2, we evaluated the reinstating effects of several priming doses of cocaine (Experiment 2A) or am…

Acoustic rhinometry in pre-school children.

1993

Acoustic rhinometry was performed in 35 normal nose-breathing children between 3 and 6 years. The average cross-sectional areas at the nasal valve, at the anterior end of the turbinates, and in the nasopharynx were 0.34 +/- 0.06 cm2, 0.35 +/- 0.08 cm2 and 1.37 +/- 0.48 cm2 respectively. The average minimal cross-sectional area was 0.29 +/- 0.06 cm2. The minimal cross-sectional area was located at the nasal valve in 14 and at the anterior end of nasal turbinates in 21 of the 35 children. As would be expected, the cross-sectional areas at different sites of the nasal cavity increased with increasing age of the children. But, whereas the minimal cross-sectional area increased by 0.024 cm2 per …

Cooperation and cultural transmission in a coordination game

2009

Abstract The aim of this paper is to analyze if cooperation can be the product of cultural evolution in a two-stage coordination game, consisting of a production stage followed by a negotiation phase. We present an overlapping generations model with cultural transmission of preferences where the distribution of preferences in the population and the strategies are determined endogenously and simultaneously. There are several groups in the society; some of them play cooperatively and others do not. Socialization takes place inside the group, but there is a positive rate of migration among groups which parents anticipate. Our main result shows that all groups converge to the cooperative equili…

Application of a model for the evaluation of the “Visitor Satisfaction” in a nature reserve of South Italy

2017

The protected natural area represents an important resource because from it sustainable and long-lasting social and economic development processes can start. In fact, the conservation of biodiversity can help create economic values by using natural capital which, if properly valorised, can help the momentum of local sustainable development and create diffuse welfare in terms of employment and income. To such a purpose, the evaluation both of the demand by those who enjoy the services of a protected area and of the level of satisfaction that visitors draw from their experience becomes a priority. The present study aims at investigating the behaviour and the preferences of the visitors to a p…

Assessing movie similarity using a multilayer network model

2021

International audience; This work investigates the movie similarity issue. A multilayer network model capturing various aspects of the story is built from movie scripts. Based on this representation, movies are compared not from summary or actors but using their storyboard. We rely on the "Portrait divergence" to quantify distances between graph characteristics. We illustrate the effectiveness of this approach in comparing movie series.

Electrophysiological evidence of memory-based detection of auditory regularity violations in anesthetized mice

2017

In humans, automatic change detection is reflected by an electrical brain response called mismatch negativity (MMN). Mismatch response is also elicited in mice, but it is unclear to what extent it is functionally similar to human MMN. We investigated this possible similarity by recording local field potentials from the auditory cortex of anesthetized mice. First, we tested whether the response to stimulus changes reflected the detection of regularity violations or adaptation to standard stimuli. Responses obtained from an oddball condition, where occasional changes in frequency were presented amongst of a standard sound, were compared to responses obtained from a control condition, where no…

Supervised reference region extraction for the quantification of [11C]-(R)-PK11195 brain studies

2006

A narrowband MIMO car-to-car channel model based on the geometrical street scattering model

2012

In this paper, we model a narrowband multiple-input multiple-output (MIMO) car-to-car (C2C) channel model based on the geometrical street scattering model. Starting from the geometrical model, a MIMO reference channel model is derived under the assumption of single-bounce scattering in line-of-sight (LOS) and non-LOS (NLOS) propagation environments. In the proposed channel model, an infinite number of scatterers are uniformly distributed in rectangular grids located on both sides of the street. Analytical solutions are presented for the three-dimensional (3D) space-time cross-correlation function (CCF), the temporal autocorrelation function (ACF), and the two-dimensional (2D) space CCF. An …