Search results for "Reference"
showing 10 items of 2491 documents
CD36 AA genotype is associated with decreased lipid taste perception in young obese, but not lean, children.
2015
Obesity is an alarming threat for all age groups, including children. Fat overconsumption is one of the factors that directly influences this pathology. Recent studies have suggested that a common variant in the CD36 gene, that is, single-nucleotide polymorphism (SNP) rs1761667-A allele, that reduces CD36 expression, associates with high oral fat detection thresholds in some obese subjects. The objective was to assess fatty acid sensitivity in relation to CD36 SNP in young lean and obese children. We studied lingual detection thresholds for emulsions, containing oleic acid, in Algerian children (n=116, age=8±0.5 years) who were divided into two groups: obese (n=57; body mass index (BMI) z-s…
Cell mechanisms of gustatory lipids perception and modulation of the dietary fat preference.
2014
Dietary lipids are usually responsible of several metabolic disorders. Recent compelling evidences suggest that there is a sixth taste modality, destined for the detection of oro-gustatory fats. The lipid-binding glycoprotein CD36, expressed by circumvallate papillae (CVP) of the mouse tongue, has been shown to be implicated in oro-gustatory perception of dietary lipids. We demonstrate that linoleic acid (LA) by activating sPLA2, cPLA2 and iPLA2 via CD36, produced arachidonic acid (AA) and lyso-phosphatidylcholine (Lyso-PC) which triggered Ca(2+) influx in CD36-positive taste bud cells (TBC), purified from mouse CVP. LA induced the production of Ca(2+) influx factor (CIF). CIF, AA and Lyso-…
CD36 and taste of fat.
2012
Purpose of review This review explores the recent literature on the role of CD36 in the taste of fat, eating behavior and obesity risk in rodents and humans. Recent findings During the last decade, evidence was accumulated supporting the existence of a taste of fat responsible for the spontaneous preference for lipid-rich foods. Surprisingly, the multifunctional membrane-associated protein CD36 appears to play a significant role in this system in rodents. Recently, another plausible gustatory lipid sensor, the GPR120, was also identified in mice, revealing that the mechanism involved in oral fat detection is more complex than initially expected. Interestingly, lingual CD36 and GPR120 displa…
Skin conductance measurement for the assessment of analgosedation adequacy in infants treated with mechanical ventilation: A multicenter pilot study
2020
Background Patients treated in neonatal/pediatric intensive care units (N/PICUs) are frequently exposed to pain. To assess its severity, several behavioral and behavioral-physiological scales are used, but their usefulness is limited. It is therefore justified to search for additional methods to assess the adequacy of analgesia and sedation in these patients. Objectives To evaluate the usefulness of skin conductance (SC) measurement in the assessment of analgosedation quality in infants requiring mechanical ventilation treated in N/PICUs. Material and methods Thirty infants aged 6-208 days treated in 6 N/PICUs, mechanically ventilated and receiving analgosedation, were included for the stud…
CUSHAW Suite: Parallel and Efficient Algorithms for NGS Read Alignment
2017
Next generation sequencing (NGS) technologies have enabled cheap, large-scale, and high-throughput production of short DNA sequence reads and thereby have promoted the explosive growth of data volume. Unfortunately, the produced reads are short and prone to contain errors that are incurred during sequencing cycles. Both large data volume and sequencing errors have complicated the mapping of NGS reads onto the reference genome and have motivated the development of various aligners for very short reads, typically less than 100 base pairs (bps) in length. As read length continues to increase, propelled by advances in NGS technologies, these longer reads tend to have higher sequencing error rat…
A new simple approach to evaluate pedogenic clay transformation in a Vertic Calcisol
2006
The aim of this study is to characterize the pedogenic clay minerals by using simple approach: Mixing mineralogical and geochemical findings. The fine clay fractions (< 0.1 μm) of a Vertic Cambisol profile were studied by means of X-ray diffraction (XRD), infrared spectroscopy (FTIR) and cation exchange capacity (CEC). Qualitative and quantitative mineralogical compositions of the clay mixture were determined. Moreover, chemical equilibria and thermodynamic stabilities of minerals (calcite, gypsum, kaolinite, smectites and illites) were studied using results of ionic activities obtained from total concentration of various aqueous species in water extracts from soil-saturated pastes. XRD ana…
Effect of Choice Feeding in the Pre-weaning Period on the Growth Performance of Calves during the Pre- and Post-weaning Periods
2017
The aim of this study was to investigate the effects of choice feeding in the pre-weaning period on the growth performance of calves during the pre- and post-weaning period. It is possible that high Crude protein (CP) intake during the pre-weaning period may improve post-weaning performance of calves. Currently, there is insufficient data available on the effect of pre-weaning feeding method on post-weaning performance of calves; therefore the aim of this study was to examine the effect of choice feeding on growth performance of calves during the pre and post-weaning period. Results: Twenty eight male and 28 female Holstein calves were assigned to two different feeding systems. After weanin…
Acute myeloid leukemia (AML)-reactive cytotoxic T lymphocyte clones rapidly expanded from CD8(+) CD62L((high)+) T cells of healthy donors prevent AML…
2008
Objective Current in vitro techniques for isolating leukemia-reactive cytotoxic T lymphocytes (CTLs) from healthy donors are of relatively low efficiency and yield responder populations with unknown biological significance. This study aimed at the development of a more reliable approach, allowing generation and expansion of acute myeloid leukemia (AML)-reactive CTLs using primary in vitro stimulation. Materials and Methods We established allogeneic mini-mixed lymphocyte-leukemia cultures (mini-MLLCs) by stimulating donor CD8 + T cells with human leukocyte antigen (HLA) class I–matched AML blasts in microtiter plates. Before culture, CD8 + T cells were separated into CD62L (high)+ and CD62L …
Assessing Preferences in Patients with Head and Neck Squamous Cell Carcinoma: Phase I and II of Questionnaire Development.
2020
Shared-decision making for head and neck squamous cell carcinoma (HNSCC) is challenged by the difficulty to integrate the patient perception of value within the framework of a multidisciplinary team approach. The aim of this study was to develop a questionnaire to assess the preferences of HNSCC patients with respect to the disease trajectory, expected treatment, and toxicities. In accordance with the standardized EORTC Quality of Life Group&rsquo
SMOS REFLEX 2003: L-band emissivity characterization of vineyards
2005
The goal of the Soil Moisture and Ocean Salinity mission over land is to infer surface soil moisture from multiangular L-band radiometric measurements. As the canopy affects the microwave emission of land, it is necessary to characterize different vegetation layers. This paper presents the Reference Pixel L-Band Experiment (REFLEX), carried out in June-July 2003 at the Vale/spl grave/ncia Anchor Station, Spain, to study the effects of grapevines on the soil emission and on the soil moisture retrieval. A wide range of soil moisture (SM), from saturated to completely dry soil, was measured with the Universitat Polite/spl grave/cnica de Catalunya's L-band Automatic Radiometer (LAURA). Concurre…