Search results for "Regional"

Evolutionary and phenotypic characterization of spike mutations in a new SARS-CoV-2 Lineage reveals two Variants of Interest

2021

Molecular epidemiology of SARS-CoV-2 aims to monitor the appearance of new variants with the potential to change the virulence or transmissibility of the virus. During the first year of SARS-CoV-2 evolution, numerous variants with possible public health impact have emerged. We have detected two mutations in the Spike protein at amino acid positions 1163 and 1167 that have appeared independently multiple times in different genetic backgrounds, indicating they may increase viral fitness. Interestingly, the majority of these sequences appear in transmission clusters, with the genotype encoding mutations at both positions increasing in frequency more than single-site mutants. This genetic outco…

The Covid-19 containment effects of public health measures:A spatial difference-in-differences approach

2021

Abstract The paper studies the containment effects of public health measures to curb the spread of Covid‐19 during the first wave of the pandemic in spring 2020 in Germany. To identify the effects of six compound sets of public health measures, we employ a spatial difference‐in‐differences approach. We find that contact restrictions, mandatory wearing of face masks and closure of schools substantially contributed to flattening the infection curve. The significance of the impact of restaurant closure does not prove to be robust. No incremental effect is evidenced for closure of establishments and the shutdown of nonessential retail stores.

Mapping the Idea of Europe : Cultural Production of Border Imaginaries through Heritage

2021

In contrast to recent reinforcements of Europe's internal and external borders due to the refugee situation on the Mediterranean and the Covid-19 outbreak, talk of European borders has in the past decades focused on the freedom of mobility guaranteed by the Schengen treaty. In many senses, free intra-European mobility has become a recited truth in the EU discourse: a phrase that hides under its repetition the gap between its implied content and empirical realities of many of those who are affected by European borders’ exclusive tendencies. Through the concept of borderscape, this article focuses on the role that cultural products – especially maps exhibited at heritage sites – have in recit…

Buccal drug delivery: what's new and what does the future hold?

2014

The buccal mucosa is the stratified squamous epithelial tissue inside lining of the cheeks. It is a favorable site of drug absorption since the tissue is non-keratinized, relatively immobile and strongly supplied with blood by a dense capillary-vessel network; moreover, it is highly tolerant to allergens, resistant to potentially harmful agents and has a relatively low enzymatic activity. The tissue consents quick onset of effect, offers an easily accessible and generally well-accepted site for drug delivery, is a useful route of administration in patients in an unconscious state (e.g., when swallowing is impaired), and is suitable for retentive dosage forms of administration. Buccal mucosa…

5-Fluororacile-loaded matrix tablets for locoregional delivery: effects on a three-dimensional culture model of primary oral squamous cell carcinoma

2012

Innovation Policies for Regional Structural Change: Combining Actor-Based and System-Based Strategies

2018

This chapter analyses opportunities and challenges for regional innovation policies designed to promote new path development in different types of regional innovation systems (RISs). RISs differ enormously in their capacity to develop new growth paths due to pronounced differences in endogenous potentials and varying abilities to attract and absorb exogenous sources for new path development. We distinguish between different types of regional industrial path development, which reflect various degrees of radicalness of regional structural change. The chapter offers a conceptual analysis of conditions and influences that enable and constrain new path development in different types of RISs and …

The evolution of Military Health in Valencia during the Spanish Civil War (1936-1939)

2011

Antecedentes y objetivos: Tras la insurrección militar del 18 de julio de 1936 el Ejército de la República quedó parcialmente desarticulado, resultando afectada la Sanidad Militar. En el caso de Valencia, ésta fue asumida rápidamente por el Comité Sanitario Popular, un organismo revolucionario que lideró la respuesta sanitaria de Valencia a la Guerra Civil. Posteriormente, el Gobierno Republicano procedió a recuperar el poder a través de medidas de carácter centralizador, como fue la militarización de algunos hospitales. Fue entonces cuando volvió a articularse una auténtica Sanidad Militar. El objetivo de este trabajo es estudiar la evolución de la Sanidad Militar en Valencia, una de las z…

Health coverage for a retreating army: a Medical Captain’s action during the Maestrazgo campaign (April-July 1938).

2012

espanolAntecedentes y objetivos: Tras la entrada definitiva de las tropas del general Franco en la ciudad de Teruel en febrero de 1938 se inicio la retirada progresiva del Ejercito de Maniobra de la republica. El rapido avance de las fuerzas nacionales hacia el Mediterraneo marco las caracteristicas de la cobertura sanitaria militar. El objetivo de este trabajo es realizar una aproximacion a la Sanidad del Ejercito republicano durante su retirada por el Maestrazgo castellonense, que tuvo lugar entre abril y julio de 1938 en el contexto de la Guerra Civil Espanola (1936-1939). Material y metodos: Hemos utilizado una fuente de gran valor historico, como es el testimonio oral de un Capitan Med…

Combined Innovation Policy: Linking Scientific and Practical Knowledge in Innovation Systems

2012

New research indicates that firms combining the science-based STI (Science, Technology, Innovation) and the experience-based DUI (Doing, Using, Interacting) modes of innovation are more efficient when it comes to improving innovation capacity and competitiveness. With regard to innovation policy, the STI mode calls for a supply driven policy, typically aimed to commercialise research results. The DUI mode suggests a demand driven policy approach, such as supporting the development of new products or services to specific markets. This paper analyses how the two types of innovation policy and the two innovation modes can be combined in regional innovation systems. The analysis builds on studi…

Cities as Enablers of Innovation

2018

The relationship between cities and innovation in present times can be regarded from a distinctive perspective. As it is vital to rethink our development patterns, in order to contrast global warming and its ominous threats, cities are themselves concrete materials for innovation. Therefore, cities challenge the very same concept of innovation by adding the long-term perspective to its social assessment framework. Cities are therefore seen both as hotbeds of creativity and innovative culture and places where different actors (policy makers, civil servants, NGOs, citizens, start-uppers, entrepreneurs, etc.) receive continuous stimuli to engage in innovations that fulfil specific needs (be th…