Search results for "Regions"
showing 10 items of 1521 documents
Noble gas geochemistry in seismic (Umbria, Italy) and volcanic (Grand Comore Island, Indian Ocean) regions: New methodologies and implications
2020
The noble gases are among the most powerful geochemical tools in different geological settings. For this reason, they represent one of the most valuable tracers of geochemical processes whose variations can be straightforwardly ascribed to magmatic/crustal dynamics. In this dissertation, noble gas (He, Ne, Ar) geochemistry applied in both seismic and volcanic regions are presented. The PhD research has firstly been devoted to the test on the field of an auto-sampler for high-frequency collection of the water samples in order to be analysed for their dissolved noble gases. Then, I developed a lab-based methodology for the in-vacuum extraction of noble gases from waters collected in the coppe…
EUROPEAN COMMITTEE OF REGIONS, REGIONAL AND LOCAL AUTONOMIES AND CONFERENCE ON THE FUTURE OF EUROPE
2022
Questo lavoro analizza il ruolo, l’organizzazione e le competenze del Comitato europeo delle Regioni alla luce dell’evoluzione normativa che ha contraddistinto l’organismo considerato il “guardiano della sussidiarietà europea” nel rapporto con i cittadini ed i territori. In particolare si approfondiscono le possibili traiettorie di riforma nella prospettiva della Conferenza sul futuro dell’Europa. This essay illustrates the role, organization and competences of the European Committee of the Regions in the light of the discipline of the European legal system. Specific consideration is given to the function of “guardian of European subsidiarity” than the Lisbon Treaty, but even more so in rel…
Isolated lip dermatitis (atopic cheilitis), successfully treated with topical tacrolimus 0.03%
2020
Background Exfoliative and erosive cheilitis, may be a source of speech and chewing discomfort, but may also be an aesthetic issue for the patients affected. Such a clinical presentation may implicate a variety of inflammatory conditions, including atopic (eczematous) cheilitis. Topical and systemic agents, e.g. corticosteroids, have been used to treat inflammatory lip conditions. Topical tacrolimus has also been used in some inflammatory lip conditions. Material and Methods We performed a retrospective clinical analysis of atopic cheilitis patients. Results Between 2015 and 2020, we addressed 7 (seven) patients with atopic dermatitis affecting only lips and were diagnosed as atopic-eczemat…
Neurophysiological Changes After Paired Brain and Spinal Cord Stimulation Coupled With Locomotor Training in Human Spinal Cord Injury
2021
Neurophysiological changes that involve activity-dependent neuroplasticity mechanisms via repeated stimulation and locomotor training are not commonly employed in research even though combination of interventions is a common clinical practice. In this randomized clinical trial, we established neurophysiological changes when transcranial magnetic stimulation (TMS) of the motor cortex was paired with transcutaneous thoracolumbar spinal (transspinal) stimulation in human spinal cord injury (SCI) delivered during locomotor training. We hypothesized that TMS delivered before transspinal (TMS-transspinal) stimulation promotes functional reorganization of spinal networks during stepping. In this p…
Comparison of 99mTc-Labeled Colloid SPECT/CT and Planar Lymphoscintigraphy in Sentinel Lymph Node Detection in Patients with Melanoma: A Meta-Analysis
2020
We compared the detection rate (DR) for sentinel lymph nodes (SLNS), the number of SLNs and the subjects with additional SLNs of single-photon emission computed tomography (SPECT/CT) and planar lymphoscintigraphy (PL) in patients with melanoma. Furthermore, we evaluated the impact of SPECT/CT on surgical plans. Articles containing head-to-head comparisons between SPECT/CT and PL were searched in Pubmed/MEDLINE and Scopus. The literature search was updated until December 31st, 2019. DR was calculated on a per-patient-based analysis; the studies were pooled by their odds ratios (ORs) with a random effects model to assess the significance of difference (p < 0.05). The number of additional S…
Rac1 and PAK1 are upstream of IKK-ε and TBK-1 in the viral activation of interferon regulatory factor-3
2004
The anti-viral type I interferon (IFN) response is initiated by the immediate induction of IFN beta, which is mainly controlled by the IFN-regulatory factor-3 (IRF-3). The signaling pathways mediating viral IRF-3 activation are only poorly defined. We show that the Rho GTPase Rac1 is activated upon virus infection and controls IRF-3 phosphorylation and activity. Inhibition of Rac1 leads to reduced IFN beta promoter activity and to enhanced virus production. As a downstream mediator of Rac signaling towards IRF-3, we have identified the kinase p21-activated kinase (PAK1). Furthermore, both Rac1 and PAK1 regulate the recently described IRF-3 activators, I kappa B kinase- and TANK-binding kina…
The origin of heavy metals and radionuclides accumulated in the soil and biota samples collected in Svalbard, near Longyearbyen
2017
Heavy metals and radioactive compounds are potentially hazardous substances for plants, animals and humans in the Arctic. A good knowledge of the spatial variation of these substances in soil and primary producers, and their sources, is therefore essential. In the samples of lichen Thamnolia vermicularis, Salix polaris and Cassiope tetragona, and the soil samples collected in 2014 in Svalbard near Longyearbyen, the concentrations of the following heavy metals were determined: Mn, Ni, Cu, Zn, Cd, Pb and Hg, as well as the activity concentrations of the following: K-40, Cs-137, Pb-210, Pb-212, Bi-212, Bi-214, Pb-214, Ac-228, Th-231 and U-235 in the soil samples. The differences in the concent…
La parifica dei rendiconti regionali: un caso ancora aperto
2022
The extension of the financial audit to the Regions reveals a physiological distortion between the function and legal regime of the institution that arises several relevant issues: on the one hand, in terms of the legal nature of this form of judgment; on the other hand, on a systematic level, with regard to its insertion in a constitutional structure at least formally characterized by a strong regionalism and a related apparatus of guarantees. In the case law of the Court of Auditors, in particular, it has not been clarified whether the financial audit is a real form of financial control or, in the light of the guidelines of the Constitutional Court, a form of jurisdiction. In the absence …
The uncertainty of the energy demand in existing mediterranean urban blocks
2013
The objective of the paper is to describe a stochastic model that has been developed to obtain load profiles for household electricity. For the study, several profiles have been generated in order to simulate the electrical demand of a residential building block or neighbourhood and evaluate the uncertainty of its energy use. The paper is divided in three different parts: development of the model, validation and determination of the uncertainty demand. In the first parts the basis of the model and how it works is explained. The second one represents the validation of the model, the input data and its results. The last step is focused on a statistical analysis of the electricity demand of a …
INSTITUTIONALISATION OF RETURN MIGRATION IN LATVIA: THE CASE OF REGIONAL COORDINATORS
2021
Emigration countries such as Latvia institutionally should address the negative consequences of the ageing populations' economic and demographic challenges. To this aim, in 2018 network of five regional return migration coordinators was established to foster and nationally encourage return migration. The primary function of the regional coordinator is to foster and facilitate requests of potential return migrants.Drawing on interview materials collected in 2020 with return migration coordinators at the regional level – Latgale, Vidzeme, Zemgale, Kurzeme and Riga, we illustrate good-practice of return migration institutionalisation in Latvia.Our study focuses on three main fields of interest…