Search results for "Regula"
showing 10 items of 6299 documents
Obtención de células madre de la pulpa dental : caracterización y adaptación a diversas condiciones de oxígeno
2013
Uno de los retos actuales de las cirugías odontológicas es la regeneración ósea, especialmente del hueso alveolar para la realización del implante dental. En los últimos años, las células madre mesenquimales derivadas la pulpa dental (CMPDs), se han convertido en un objetivo de estudio prometedor para la regeneración ósea gracias a su potencial de diferenciación a odontoblastos y osteoblastos así como sus propiedades inmunológicas. Sin embargo, su aplicación sigue siendo limitada por el gran número de células y el tiempo requerido para su obtención. Para ello, nos propusimos el objetivo de optimizar el tiempo de obtención de las CMPDs en la condición fisiológica de oxígeno (3-6% O2) así com…
Sparse nonnegative tensor decomposition using proximal algorithm and inexact block coordinate descent scheme
2021
Nonnegative tensor decomposition is a versatile tool for multiway data analysis, by which the extracted components are nonnegative and usually sparse. Nevertheless, the sparsity is only a side effect and cannot be explicitly controlled without additional regularization. In this paper, we investigated the nonnegative CANDECOMP/PARAFAC (NCP) decomposition with the sparse regularization item using l1-norm (sparse NCP). When high sparsity is imposed, the factor matrices will contain more zero components and will not be of full column rank. Thus, the sparse NCP is prone to rank deficiency, and the algorithms of sparse NCP may not converge. In this paper, we proposed a novel model of sparse NCP w…
Les enjeux de la professionnalisation des agents de développement. L’ingénierie territoriale prise en étau entre les conceptions organique et mécanis…
2011
International audience; Cet article relie les mécanismes de régulation de l’action publique territoriale à des enjeux de professionnalisation des agents de développement, acteurs pivot de l’ingénierie territoriale. Ceux-ci, inscrits dans des communautés épistémiques, posent les jalons d’une régulation pragmatique de l’action publique.Cependant, le registre concurrentiel de l’excellence territoriale couplé aux nouvelles formes de contrôles bureaucratique transforme les territoires de projet en segments d’exécution de politiques définies par des agences regroupant expertise et gestion. Au final, la personnalité bureaucratique des agents de développement l’emporte sur leur rôle d’ « agitateurs…
Kryminalizowanie finansowania terroryzmu
2016
El impacto del cambio climático en la movilidad humana : las migraciones climáticas en el contexto internacional y europeo
2021
For decades, the migration phenomenon has been one of the thorniest regulatory issues in the European Union (EU) policy. In addition, today, the fight against climate change in all regions of the world makes the situation worse for the new ?climate refugees? or ?environmental displaced people?, whose legal status is not yet covered by the ancient 1951 Refugee Convention.
The variation of the law applicable to the family property regime in EU regulations n. 2016/1103 and 1104
2021
The essay examines the discipline of EU regulations n. 2016/1103 and 1104 concerning the identification of the law applicable to the family property regime. Specifically, the work reflects on problems arising after a change, during the relationship, of the substantial law applicable to the couple?s property regime.
MTOR inhibitor-based combination therapies for pancreatic cancer
2018
Background: Although the mechanistic target of rapamycin (MTOR) kinase, included in the mTORC1 and mTORC2 signalling hubs, has been demonstrated to be active in a significant fraction of patients with pancreatic ductal adenocarcinoma (PDAC), the value of the kinase as a therapeutic target needs further clarification. Methods: We used Mtor floxed mice to analyse the function of the kinase in context of the pancreas at the genetic level. Using a dual-recombinase system, which is based on the flippase-FRT (Flp-FRT) and Cre-loxP recombination technologies, we generated a novel cellular model, allowing the genetic analysis of MTOR functions in tumour maintenance. Cross-species validation and pha…
Response to the Letter to the editor regarding “Targeting NUPR1 with the small compound ZZW-115 is an efficient strategy to treat hepatocellular carc…
2021
Zero-Heat-Flux and Esophageal Temperature Monitoring in Orthopedic Surgery: An Observational Study
2021
Judy Munday,1,2 Niall Higgins,1,3 Lee Jones,1,4 Dimitrios Vagenas,4 André Van Zundert,1,5,6 Samantha Keogh1,3 1School of Nursing & Centre for Healthcare Transformation, Faculty of Health, Queensland University of Technology, Kelvin Grove, QLD, Australia; 2Department of Health and Nursing Science, Faculty of Health and Sports Sciences, University of Agder, Grimstad, Norway; 3Royal Brisbane and Womenâs Hospital, Herston, QLD, Australia; 4Research Methods Group, Institute of Health and Biomedical Innovation (IHBI), Faculty of Health, Queensland University of Technology, Kelvin Grove, QLD, Australia; 5Department of Anaesthesia and Perioperative Medicine, Royal Brisbane and Womenâs Hosp…
Uzņēmumam piemītošo cilvēktiesību aizsardzība konkurences tiesību pārkāpumu izmeklēšanas procesā
2021
Konkurences tiesības ir tiesisks instruments, kas nodrošina efektīvu brīvā tirgus darbību un tautsaimniecības attīstību, komplementāri aizsargājot sabiedrības kopējo labklājību. Izrietoši, konkurences tiesību pārkāpumu identificēšana, atklāšana un izmeklēšana ir pašmērķis, kura sasniegšanu ir jāveicina konkurences iestādei. Vienlaikus konkurences tiesību pārkāpumu izmeklēšanas procesam ir jābūt efektīvām un tiesiskam, konkurences iestādei īstenojot izmeklēšanas darbības un piemērojot uzņēmuma cilvēktiesības vismazāk ierobežojošus līdzekļus. Autore darbā analizē šobrīd spēkā esošo Eiropas Savienības konkurences tiesību regulēju…