Search results for "Reich"
showing 10 items of 93 documents
Archeologia dziewiętnastowiecznej pamięci w insurekcyjnym tryptyku Jarosława Iwaszkiewicza ("Noc czerwcowa", "Zarudzie", "Heydenreich")
2013
Three short “insurrection” stories written by Jarosław Iwaszkiewicz in the years 1963–1974 have inspired various interpretations; it seems, however, that there are still many undeciphered codes, references, and allusions. The author’s metatextual comments as well as the implicit poetics of the stories make it possible to consider them as a dialogue with the historical, cultural and aesthetic heritage of the 19th century: as a form of its literary archeology. The article deals with many literary and aesthetic conventions employed in the stories, with the emphasis on the concept of sérénité and on various associations with 19th-century art. Notably, the scope of analysis includes such motifs …
Du Néolithique récent à l’âge du Bronze dans le Centre Nord de la France : les étapes de l’évolution chrono-culturelle
2011
Die seit 2001 im Rahmen eines PCR (Programme Collectif Régional) durchgeführte Gemeinschaftsarbeit über das Ende des Neolithikums und den Beginns der Bronzezeit im Zentrum Nordfrankreichs führt heute zu einer neuen Periodisierung der Zeit zwischen 3600 und 1800 v. Chr. in acht Etappen. Obwohl, insbesondere bezüglich der Transition zwischen dem Mittel-und dem Jungneolithikum einerseits und dem Jung-und dem Endneolithikum andererseits, auch weiterhin einige Lücken bestehen, erlaubt dieser präzisere Rahmen die Hauptetappen im Zentrum Nordfrankreichs mit denen der benachbarten Regionen zu synchronisieren, um eine dynamischere Vision der kulturellen Phänomene vorzuschlagen.
Climate–human interactions contributed to historical forest recruitment dynamics in Mediterranean subalpine ecosystems
2020
Long-term tree recruitment dynamics of subalpine forests mainly depend on temperature changes, but little is known about the feedbacks between historical land use and climate. Here, we analyze a southern European, millennium-long dataset of tree recruitment from three high-elevation pine forests located in Mediterranean mountains (Pyrenees, northeastern Spain; Pollino, southern Italy; and Mt. Smolikas, northern Greece). We identify synchronized recruitment peaks in the late 15th and early 16th centuries, following prolonged periods of societal and climate instability. Major European population crises in the 14th and 15th centuries associated with recurrent famines, the Black Death pandemic,…
High-elevation inter-site differences in Mount Smolikas tree-ring width data
2017
Abstract We present the longest high-elevation tree-ring width dataset in the Mediterranean reaching back to the 6th century CE. The network includes 101 living and 92 relict Pinus heldreichii Christ trees from four differently exposed sites in the 2100–2200 m a.s.l. elevation range of Mt. Smolikas in the Pindus Mountains in Greece. Though the sites were all sampled within a distance of 1550–2014 = 0.65–0.87), indicating site exposure might affect tree-ring formation. We here explore the consequence of exposure differences on the climate signals in an eastern Mediterranean treeline ecotone. Temporally stable growth/climate relationships reveal similar seasonal patterns among the four sites…
Does an ant-dispersed plant, Viola reichenbachiana, suffer from reduced seed dispersal under inundation disturbances?
2008
Many plant species use ants as seed dispersers. This dispersal mode is considered to be susceptible to disturbances, but the effect of natural, small-scale disturbances is still unknown. We investigated how small-scale disturbances due to inundation affect seed dispersal in Viola reichenbachiana, a dominant myrmecochorous herb in riparian forests. Inundation disturbances were high in depressions and low on hillocks of the forest floor. We found that V reichenbachiana was similarly abundant at highly and less disturbed sites, contrary to other, non ant-dispersed species. We also found that the motivation of ants to disperse seeds was higher at highly disturbed sites. Nevertheless, the number…
PPAR gamma agonist leriglitazone improves frataxin-loss impairments in cellular and animal models of Friedreich Ataxia
2020
Friedreich ataxia (FRDA), the most common autosomal recessive ataxia, is characterized by degeneration of the large sensory neurons and spinocerebellar tracts, cardiomyopathy, and increased incidence in diabetes. The underlying pathophysiological mechanism of FRDA, driven by a significantly decreased expression of frataxin (FXN), involves increased oxidative stress, reduced activity of enzymes containing iron‑sulfur clus-ters (ISC), defective energy production, calcium dyshomeostasis, and impaired mitochondrial biogenesis, leading to mitochondrial dysfunction. The peroxisome proliferator-activated receptor gamma (PPARγ) is a ligand-activated transcriptional factor playing a key role in mito…
Oxidative stress modulates rearrangement of endoplasmic reticulum-mitochondria contacts and calcium dysregulation in a Friedreich's ataxia model
2020
Friedreich ataxia (FRDA) is a neurodegenerative disorder characterized by neuromuscular and neurological manifestations. It is caused by mutations in the FXN gene, which results in loss of the mitochondrial protein frataxin. Endoplasmic Reticulum-mitochondria associated membranes (MAMs) are inter-organelle structures involved in the regulation of essential cellular processes, including lipid metabolism and calcium signaling. In the present study, we have analyzed in both, unicellular and multicellular models of FRDA, calcium management and integrity of MAMs. We observed that function of MAMs is compromised in our cellular model of FRDA, which was improved upon treatment with antioxidants. I…
Reversible Axonal Dystrophy by Calcium Modulation in Frataxin-Deficient Sensory Neurons of YG8R Mice
2017
15 Pages, 8 Figures. The Supplementary Material for this article can be found online at: http://journal.frontiersin.org/article/10.3389/fnmol.2017.00264/full#supplementary-material
Friedreich Ataxia: current state-of-the-art, and future prospects for mitochondrial-focused therapies
2021
Friedreichs Ataxia is an autosomal recessive genetic disease causing the defective gene product, frataxin. A body of literature has been focused on the attempts to counteract frataxin deficiency and the consequent iron imbalance, in order to mitigate the disease-associated prooxidant state and clinical course. The present mini review is aimed at evaluating the basic and clinical reports on the roles and the use of a set of iron chelators, antioxidants and some cofactors involved in the key mitochondrial functions. Extensive literature has focused on the protective roles of iron chelators, coenzyme Q10 and analogs, and vitamin E, altogether with varying outcomes in clinical studies. Other st…
Oxidative Stress, a Crossroad Between Rare Diseases and Neurodegeneration
2020
Oxidative stress is an imbalance between production and accumulation of oxygen reactive species and/or reactive nitrogen species in cells and tissues, and the capacity of detoxifying these products, using enzymatic and non-enzymatic components, such as glutathione. Oxidative stress plays roles in several pathological processes in the nervous system, such as neurotoxicity, neuroinflammation, ischemic stroke, and neurodegeneration. The concepts of oxidative stress and rare diseases were formulated in the eighties, and since then, the link between them has not stopped growing. The present review aims to expand knowledge in the pathological processes associated with oxidative stress underlying …