Search results for "Renta"
showing 10 items of 733 documents
Addressing HCV Elimination Barriers in Italy: Healthcare Resource Utilization and Cost Impact Using 8 Weeks’ Glecaprevir/Pibrentasvir Therapy
2021
Introduction: In Italy, hepatitis C virus (HCV) elimination is achievable; however, barriers remain to achieving the World Health Organization's elimination targets, and have become more pronounced with the spread of COVID-19. Glecaprevir/pibrentasvir (G/P) is a direct-acting antiviral therapy for HCV, approved for 8-week treatment in patients without cirrhosis, and with compensated cirrhosis (CC). Previously, 12 weeks of therapy was recommended for patients with CC. Shortened treatment may reduce the burden on healthcare resources, allowing more patients to be treated. This study presents the benefits that 8-week vs 12-week treatment with G/P may have in Italy. Methods: A multicohort Marko…
Gene expression changes after parental exposure to metals in the sea urchin affect timing of genetic programme of embryo development
2021
Simple Summary Intergenerational and transgenerational effects, in which exposure to stressors in a parental generation affects the phenotype of the offspring have been connected to anthropic impacts on biological systems. Therefore, environmental stress experienced inside a generation, particularly during gametogenesis, may lead to erroneous patterns in their offspring just emerging at early developmental stages. In this scenario, the sea urchin embryo represents a suitable model for integrating analyses of gene expression through embryogenesis with developmental alteration induced by environmental stressors. Herein we provide pieces of evidence for the alteration of the gene regulatory ne…
The Coat-Hanger Angle Sign
2016
An infant boy, the second child of healthy parents, was born at 35.5 weeks of gestation by cesarean delivery performed in emergency because of fetal bradycardia and polyhydramnios. At birth his weight was 2770 g (62nd percentile), length 48.3 cm (69th percentile), and head circumference 33.5 cm (64th percentile). Findings of a phys- ical examination showed a broad forehead, a depressed nasal bridge, anteverted nares, a long and protruding philtrum, a high arched palate, retrognathia, joint contractures, and an umbilical hernia. The Apgar score was 6/8 at 1/5 minutes. Because of progressive respiratory distress he required hos- pitalization and noninvasive support ventilation for the first 3…
Real life experiences in HCV management in 2018
2019
Introduction: Hepatitis C virus (HCV) infection is a major cause of chronic liver disease, with approximately 71 million chronically infected individuals worldwide. Treatment of chronic hepatitis C has considerably improved in the last few years thanks to the introduction of direct-acting antivirals able to achieve sustained virological response in more than 95% of patients. Successful anti-HCV treatment can halt liver disease progression and solve the HCV-related extra-hepatic manifestations, eventually reducing liver-related and overall mortality. Areas covered: With the aim to respond to unmet needs in patient’s identification, universal access to antiviral therapy and treatment optimiza…
RELACIÓN ENTRE ESTRÉS PARENTAL Y HABILIDADES LINGÜÍSTICAS EN NIÑOS CON TEA
2016
Abstract:The objectives of this study were: 1) Compare the perceived parental stress between a group of parents of children with ASD and a group of parents of children with typical development. The rest of the objectives are focused on the analysis of the ASD group.2) Compare the perceived parental stress between the parents of the ASD children with language and the parents of the ASD children without language. 3) Analyze the relationship between the perceived parental stress and the child’s receptive linguistic skills. 4) Analyze the relationship between the perceived parental stress and the child’s expressive linguistic skills. The Parenting Stress Index scale (the child domain) was used …
Psychological predictors of homophobic bullying among adolescents and young adults: The role of parental psychological control and sensation seeking
2021
AbstractWe aimed to investigate the relationship between homophobic bullying, parental psychological control and sensation seeking among adolescents and young adults and to examine the mediating role of sensation seeking. The participants included 394 adolescents and young adults aged 15 to 20 years attending the 3rd, 4th and 5th years of two public high schools in Italian cities. Participants completed the Homophobic Bullying Scale, the Dependency—oriented and Achievement—oriented Parental Psychological Control, and the Sensation—Seeking Scale. The results showed that parental psychological control predicted bullying toward gay and lesbian people. However, the two dimensions of sensation s…
Mindfulness-Based Stress Reduction (MBSR) and Self Compassion (SC) Training for Parents of Children with Autism Spectrum Disorders: A Pilot Trial in …
2021
This study aims to develop a clinical trial to test the efficacy of a mindfulness-based stress reduction (MBSR) and self-compassion (SC) program on self-reported values of anxiety, depression, and stress in parents of children with autism spectrum disorder (ASD) in primary school, in order to assess their integration into the framework of community intervention programs in Spain. Methods: A brief 8-week training program using mindfulness-based intervention (MBSR) and self-compassion (SC) has been applied to twelve Valencian ASD parents, ten of whom completed the program. Participants were assigned to two groups
CAN I TELL JUST BY MYSELF? DISCUSSING A PARENTAL MENTAL DISORDER WITH A CHILD IN A RESEARCH INTERVIEW
2016
In this single-case study, we focus on how to have a dialogue in a research interview with a child whose parent has been diagnosed with a mental disorder. The interactional context and the interviewer’s role in co-constructing the child’s accounts have been largely neglected in the qualitative psychological research on this subject. Stigma related to mental disorders is increasingly being recognized as a central issue for the entire mental health field. It is considered to have far-reaching effects on the social interaction of the stigmatized person and also to contaminate the interactions of those around that person. We examine how the stigma of a parental mental disorder arises and is neg…
Paternal uniparental disomy chromosome 14-like syndrome due a maternal de novo 160 kb deletion at the 14q32.2 region not encompassing the IG- and the…
2015
The human chromosome 14q32 carries a cluster of imprinted genes which include the paternally expressed genes (PEGs) DLK1 and RTL1, as well as the maternally expressed genes (MEGs) MEG3, RTL1as, and MEG8. PEGs and MEGs expression at the 14q32.2-imprinted region are regulated by two differentially methylated regions (DMRs): the IG-DMR and the MEG3-DMR, which are respectively methylated on the paternal and unmethylated on the maternal chromosome 14 in most cells. Genetic and epigenetic abnormalities affecting these imprinted gene clusters result in two different phenotypes currently known as maternal upd(14) syndrome and paternal upd(14) syndrome. However, only few patients carrying a maternal…
Consumo de alcohol, tabaco, cannabis y otras drogas en la adolescencia: efectos de la familia y peligro del barrio
2015
El objetivo de este estudio fue analizar los factores de protección o riesgo de los estilos educativos parentales para el consumo de alcohol, tabaco, cannabis y otras drogas, considerando la interacción de los estilos parentales con la peligrosidad del barrio. A partir de las respuestas de 628 adolescentes, 369 mujeres (58.8%) y 259 hombres (41.2%) entre 15 y 17 años (M = 16.03 años, DT = 0.79 años), se clasificaron las familias según el estilo educativo (autorizativo, indulgente, autoritario o negligente) y el riesgo percibido en el barrio (alto o bajo). Los resultados no mostraron interacciones, pero sí efectos principales de los estilos educativos y del riesgo percibido. Los adolescentes…