Search results for "Repo"

ID4 Is Required for Normal Ependymal Cell Development

2021

Ependymal cells are radial glia-derived multiciliated cells lining the lateral ventricles of the brain and spinal cord. Correct development and coordinated cilia beating is essential for proper cerebrospinal fluid (CSF) flow and neurogenesis modulation. Dysfunctions of ependymal cells were associated with transcription factor deregulation. Here we provide evidence that the transcriptional regulator ID4 is involved in ependymal cell development and maturation. We observed that Id4-deficient mice display altered ventricular cell cytoarchitecture, decreased ependymal cell number and enlarged ventricles. In addition, absence of ID4 during embryonic development resulted in decreased ependymal ce…

Presurgical role of MRI tractography in a case of extensive cervicothoracic spinal ependymoma

2017

Background: Intramedullary spinal ependymoma is a tumor, hardly characterizable with conventional magnetic resonance (MR) imaging only. MR diffusion tensor imaging (DTI) with three dimensional fiber tracking reconstructions allows the evaluation of the relationship between neoplasm and white matter fiber tracts, being a powerful tool in presurgical planning. We present DTI findings in a case of a young female with an extensive cervicothoracic spinal ependymoma. Case Description: The patient complained of a 2 month history of acute urinary retention, weakness and numbness on the lower limbs and the upper left limb. She underwent MR imaging that showed an extensive cervicothoracic spinal mass…

Further development of the β-lactamase MutaGen assay and evaluation by comparison with Ames fluctuation tests and theumu test

2005

A rapid, high-throughput bacterial mutagenicity test system has been developed (MutaGen test) that detects reversions of inactivating base-pair substitutions and frameshifts in a TEM-1 class A β-lactamase (ampicillinase) gene. To quickly and sensitively detect mutagens, the system utilises a series of plasmids that contain the mutated ampicillinase gene and the mucAB operon. Inactivating mutations in the ampicillinase gene include frameshifts integrated into repetitive GC-sequences and G-runs known to be mutagenic hot-spots, and base-pair substitutions inserted in or around the β-lactamase active site. Frameshift mutations completely inactivated the enzyme only when located downstream of th…

Confirmatory factor analysis of the proxy version of Kidscreen-27 and relationships between health-related quality of life dimensions and body mass i…

2020

Highlights • The full Kidscreen-27 should be used with caution for young children. • Physical activity was positively associated with physical well-being. • Body mass was negatively associated with physical well-being. • Compared to older children, the youngest may have more negative school experiences.

Two Half-Truths Make a Whole? On Bias in Self-Reports and Tracking Data

2019

The pervasive use of mobile information technologies brings new patterns of media usage, but also challenges to the measurement of media exposure. Researchers wishing to, for example, understand the nature of selective exposure on algorithmically driven platforms need to precisely attribute individuals’ exposure to specific content. Prior research has used tracking data to show that survey-based self-reports of media exposure are critically unreliable. So far, however, little effort has been invested into assessing the specific biases of tracking methods themselves. Using data from a multimethod study, we show that tracking data from mobile devices is linked to systematic distortions in sel…

Red Cell Membrane Protein Lateral Mobility in Vascular Atherosclerotic Disease: Preliminary Report

1993

Influence of Training Load on Mood Disturbance at Sea Level and 3900 m Altitude: A Case Study of a Wheelchair Athlete

2018

The purpose of this case study was to investigate the influence of a training load (TL), oxygen saturation (SO2) and blood pressure (BP) on mood states in a wheelchair marathoner during (7 weeks at sea level (SL), 5 weeks at 3860 m altitude, 1 week returning to SL). TL was obtained with Foster’s equation while mood states were obtained with the Profile of Mood States Questionnaire (POMS). Furthermore, SO2 and BP were assessed upon wakening. SO2 (%) decreased at altitude, compared to SL (88.31 ± 2.46 vs. 98.52 ± 0.11) and increased until the last week at altitude (92.64 ± 1.12). Systolic pressure (SP) increased at altitude compared to pre-altitude (126.0 ± 5…

Using Wavelet Techniques to Approximate the Subjacent Risk of Death

2018

In Actuarial science, graduation techniques have been used extensively: the large number of scientific papers and technical documentation published evidences this fact (see Ayuso M et al. (Estadistica Actuarial Vida. UBe, Barcelona (2007)), Baeza Sampere and Morillas Jurado (Rev. Anales del Instituto de Actuarios Espanoles 135–164 (2011)), London (Graduation: The Revision of Estimates. ACTEX Publications, Connecticut (1985)), Cairns, et al. (Scand Actuar J 2(3):79–113 (2008)) and the references therein). Graduation techniques are defined by Haberman and Renshaw J Inst Actuar 110:135–156 (1983) as a set of principles and techniques for use that are used on raw data so that a more appropriate…

The Effects of IFRS Adoption on the Unconditional Conservatism of Spanish Listed Companies

2017

This paper analyses the effects on unconditional conservatism of the mandatory adoption of International Financial Reporting Standards (IFRS) by Spanish listed companies in January 2005. The lack of robustness in the previous evidence justifies analysing this issue from different perspectives. To this end, we use, for the first time in this context, Ahmed and Duellman’s methodology (J. Account. Econ., 2007). In its design, these authors consider the impact of growth options and other future incomes, controlling for the idiosyncratic factors that the literature has found to condition this type of conservatism. Additionally, beyond the pooled regression techniques usually used, we use econome…

Socioemotional characteristics of minors in foster care: A comparison between the estimation of parents, teachers and children

2013

Abstract During the child's first few years, it's of fundamental importance the presence of a strong emotional base as long as it creates the possibility to open themselves to physical and social world with confidence, and as it acts as a facilitator of cognitive development. For this reason, if the family cannot ensure such base, social services are forced to resort to foster care, a resource that has a lot of difficulties, leading to different implications in the development of the child and of the foster family. It is therefore important to analyze in depth the socio-emotional variables that characterize children who are in a situation of foster care in order to provide adequate assistan…