Search results for "Repo"
showing 10 items of 2753 documents
Avoimuudella on merkitystä! Kirjaston julkaisuyksikkö Jyväskylän yliopiston vaikuttavuuden edistäjänä
2012
Julkaisuyksikkö on toimintansa alusta alkaen tähdännyt Jyväskylän yliopiston näkyvyyden ja menestymisen sekä tieteen avoimuuden tukemiseen. Pekka Olsbo käy artikkelissaan läpi julkaisuyksikön toiminnan keskeisiä virstanpylväitä. Julkaisuyksikkö on vuosien saatossa vakiinnuttanut asemansa yliopiston keskeisenä palveluyksikkönä. Yliopistossa tuotettavien moninaisten digitaalisten aineistojen verkkojulkaisemisen myötä se myös jatkaa työtään kansallisen open access -työn eturintamassa. nonPeerReviewed
Regulation of X Chromosome-Linked Inhibitor of Apoptosis Protein (XIAP) in Kainic Acid Induced Neuronal Cell Death in the Rat Hippocampus
2001
INTRODUCTION. Inhibitor of apoptosis protein (IAP) family consists of several antiapoptotic proteins conserved among species. The IAPs have a well-conserved motif of approximately 65 residues, called the baculovirus inhibitory repeat (BIR) (1). Baculovirus and drosophila IAPs have two, but most IAPs contain three BIR domains. Most of the IAPs also have a C-terminal RING domain which consists of conserved amino acids with zinc binding capacity. XIAP is one of the five known human IAPs and it binds directly and inhibits the activity of caspases (2). The BIR2 domain in XIAP is sufficient to mediate this inhibition (3). However little is known about the presence and function of XIAP in the nerv…
Epigenetic control of IL-23 expression in keratinocytes is important for chronic skin inflammation
2018
The chronic skin inflammation psoriasis is crucially dependent on the IL-23/IL-17 cytokine axis. Although IL-23 is expressed by psoriatic keratinocytes and immune cells, only the immune cell-derived IL-23 is believed to be disease relevant. Here we use a genetic mouse model to show that keratinocyte-produced IL-23 is sufficient to cause a chronic skin inflammation with an IL-17 profile. Furthermore, we reveal a cell-autonomous nuclear function for the actin polymerizing molecule N-WASP, which controls IL-23 expression in keratinocytes by regulating the degradation of the histone methyltransferases G9a and GLP, and H3K9 dimethylation of the IL-23 promoter. This mechanism mediates the inducti…
Two rare cases of oral metastasis arising from lung adenocarcinoma and esophageal carcinoma
2020
Metastasis to the oral cavity are rare, representing only 1% of all oral malignancies, and originate from various sites such as the breast, prostate, lung and kidney. Clinically, they can simulate reactive and inflammatory lesions common in the oral cavity, and the clinical and microscopic diagnosis of these metastasis is a challenge. In this article, we report two new cases of esophageal and lung metastasis to oral tissues, highlighting their clinical characteristics and the process of diagnostic elucidation. We emphasize the importance for clinicians to consider the possibility of metastatic lesions in the oral cavity in patients previously diagnosed with malignant lesions in distant tiss…
Effects of whole-body vibration exercise on muscular strength and power, functional mobility and self-reported knee function in middle-aged and older…
2013
Abstract Background Whole-body vibration training using vertical-vibration machines is called “acceleration training” (AT). The purpose of this study was to elucidate the effect of AT on lower-limb muscular strength and power, functional mobility and self-reported knee function in middle-aged and older Japanese women with knee pain. Methods Thirty-eight middle-aged and older Japanese women (aged 50–73 years) with knee pain were divided into two groups: (1) the AT group (n = 29) engaged in AT three times per week for eight weeks, and (2) the control group (C group, n = 9). The AT program consisted of flexibility training, strength training of mainly the quadriceps and surrounding muscles and…
On the use of information systems research methods in data mining
2006
Information systems are powerful instruments for organizational problem solving through formal information processing (Lyytinen, 1987). Data mining (DM) and knowledge discovery are intelligent tools that help to accumulate and process data and make use of it (Fayyad, 1996). Data mining bridges many technical areas, including databases, statistics, machine learning, and human-computer interaction. The set of data mining processes used to extract and verify patterns in data is the core of the knowledge discovery process. Numerous data mining techniques have recently been developed to extract knowledge from large databases. The area of data mining is historically more related to AI (Artificial…
The Common Good Balance Sheet, an Adequate Tool to Capture Non-Financials?
2019
In relation to organizational performance measurement, there is a growing concern about the creation of value for people, society and the environment. The traditional corporate reporting does not adequately satisfy the information needs of stakeholders for assessing an organization&rsquo
Explorando la divulgación de información integrada por universidades colombianas. Un análisis de páginas web basado en el marco del IIRC
2021
La información integrada se presenta como un fenómeno de reciente auge que permite a diversas organizaciones informar de una manera simplificada pero completa sobre su gestión respecto a diversos tipos de capitales. Aunque predominantemente se ha desarrollado en las empresas privadas, en el ámbito internacional viene reconociéndose que otro tipo de organizaciones como las universidades, divulgan esta información o cuentan con la necesidad y el potencial para ello. Este trabajo tiene como objetivo analizar en qué medida la información solicitada para construir un reporte integrado de acuerdo con los requerimientos del Marco Conceptual del IIRC, ya está revelada en internet por las universida…
The role of social report for performance measurement of museums: an Italian survey from the web
2017
This paper aims to explore the concept of performance in the museum field, in particular whether and how it could find an adequate representation through social reporting tools. The social reports, indeed, in non-profit and public sector organisations are typically considered the main tools for institutional communication. To investigate on this topic, we analyse the social reports of some Italian museums using the content analysis in order to understand how the performance is evaluated and communicated. The empirical findings show how the reports are not fully able to represent the performance of the museums.
Kyrieleis’ vasculitis in acute retinal necrosis
2010
We report the first case in the literature of Kyrieleis' vasculitis related to acute retinal necrosis by Varicella zoster virus in a 76-year-old woman with bilateral involvement. In our patient the arterial lesions appeared 15 days after the initial presentation.