Search results for "Reproducibility"
showing 10 items of 1976 documents
MicroRNA hsa-miR-4717-5p regulates RGS2 and may be a risk factor for anxiety-related traits
2015
Regulator of G-protein Signaling 2 (RGS2) is a key regulator of G-protein-coupled signaling pathways involved in fear and anxiety. Data from rodent models and genetic analysis of anxiety-related traits and disorders in humans suggest down-regulation of RGS2 expression to be a risk factor for anxiety. Here we investigated, whether genetic variation in microRNAs mediating posttranscriptional down-regulation of RGS2 may be a risk factor for anxiety as well. 75 microRNAs predicted to regulate RGS2 were identified by four bioinformatic algorithms and validated experimentally by luciferase reporter gene assays. Specificity was confirmed for six microRNAs (hsa-miR-1271-5p, hsa-miR-22-3p, hsa-miR-3…
General Factor of Personality Questionnaire (GFPQ): Only one Factor to Understand Personality?
2010
This study proposes a psychometric approach to assess the General Factor of Personality (GFP) to explain the whole personality. This approach defends the existence of one basic factor that represents the overall personality. The General Factor of Personality Questionnaire (GFPQ) is presented to measure the basic, combined trait of the complete personality. The questionnaire includes 20 items and is constituted by two scales with 10 items each one: the Extraversion Scale (ES) and the Introversion Scale (IS). The GFPQ shows adequate internal consistency and construct validity, while the relationships with the personality factors of other models and with psychopathology are as expected. It cor…
The relationship of personality traits to substance abuse in patients with bipolar disorder
2007
AbstractPurposeThe aim of this study is to determine if personality traits contribute to the likelihood of substance abuse in Bipolar Disorder (BD).Subjects/materials and methodsFifty-nine patients meeting DSM-IV criteria for BD: 20 without any history of Substance Related Disorder (SRD), 21 with a lifetime history of SRD but without current SRD, and 18 with current SRD. Patients filled out the TCI, the differences were analyzed by ANOVA and the likelihood was obtained by Multinomial Logistic Regression.ResultsOnly Novelty Seeking (NS) is statistically different between the groups. Patients with BD with current SRD have higher rates in NS than those with past SRD, and those without a histor…
Comparison between direct and predicted maximal oxygen uptake measurement during cycling.
2013
Predicted maximal oxygen uptake (VO2max) measurements are based on the assumption of linear relationship between heart rate or power output and oxygen consumption during various intensities. To develop more reliable predicted test for soldiers, the purpose of the present study was to compare the results of direct measurements of VO2max to respective predicted values in cycling (military fitness test). The predicted mean (+/- SD) peak oxygen uptake (VO2peak) value was 45.2 +/- 7.7 mL kg(-1) min(-1) during first week, whereas the respective direct value was 44.8 +/- 8.5 mL kg(-1) min(-1). During the ninth week, the predicted and measured mean (+/-SD) VO2max values were 47.4 +/- 6.7 mL kg(-1) …
Mother-child interactional patterns in high-and low-risk mothers
1998
Abstract Objective: The aim of the present study was to determine the extent to which mother-child interactional patterns in high-and low-risk (for child physical abuse) mothers were similar to patterns observed in physically abusive parents. Method: Ten high-risk and 10 demographically similar low-risk mother-child dyads were studied. Trained observers coded maternal-child interaction patterns in the home during five 1-hour periods using the Standardized Observation Codes system. Results: As expected, high-risk mothers made fewer neutral approaches to their children, displayed more negative behaviors toward their children, and made more indiscriminant responses to their children's prosocia…
Intrasubject repeatability of corneal power, thickness, and wavefront aberrations with a new version of a dual rotating Scheimpflug–Placido system
2014
Purpose To determine the intrasubject repeatability of a recently introduced dual-camera rotating Scheimpflug–Placido imaging system (Galilei G4) in determining corneal thickness, power, and wavefront aberrations in young healthy subjects. Setting University of Valencia, Valencia, Spain. Design Prospective evaluation of diagnostic technology. Methods The study comprised right eyes of 25 subjects aged 20 to 40 years with a spherical equivalent ranging from −4.25 to +1.00 diopters. The central corneal thickness, thinnest point value and location, anterior and posterior surface curvatures, total corneal power, and corneal wavefront aberrations were measured for distance vision using the dual S…
Development and validation of a reliable method for studying the distribution pattern for opiates metabolites in brain
2012
Abstract Brain distribution pattern of “street” heroin metabolites (morphine and codeine) was investigated in two fatalities due to “acute narcotism”. A suitable sample pretreatment prior to solid-phase-extraction was developed to achieve a good recovery of the analytes and to eliminate the interfering species. After derivatization with MSTFA, samples were analyzed by GC/MS. Specificity, accuracy, precision and linearity of the method were evaluated; LOD and LOQ were, respectively, 10 ng/25 ng for morphine and 5 ng/10 ng for codeine. This method was applied to the analysis of six brain areas (hippocampus, frontal lobe, occipital lobe, nuclei, bulb and pons) coming from two cases of heroin-r…
Confirmatory Factor Analysis of the Valencia Scale of Attitudes and Beliefs Toward Hypnosis–client Version in a Portuguese Sample
2018
Research literature about hypnosis highlights the importance of clients' attitudes and beliefs toward hypnosis because they promote hypnotic responses and may predict the effectiveness of hypnotic interventions as well as minimize iatrogenic effects for clients. This study analyzes the factorial structure and psychometric properties with confirmatory methodology of the Valencia Scale of Attitudes and Beliefs Toward Hypnosis-Client Version, using a Portuguese sample. We expected to replicate the results obtained in previous research conducted with samples from various countries. The Portuguese sample comprised 1,977 participants. We found a structure of 8 factors, with an adequate internal c…
Permanently online and permanently connected : development and validation of the Online Vigilance Scale
2017
Smartphones and other mobile devices have fundamentally changed patterns of Internet use in everyday life by making online access constantly available. The present paper offers a theoretical explication and empirical assessment of the concept of online vigilance, referring to users' permanent cognitive orientation towards online content and communication as well as their disposition to exploit these options constantly. Based on four studies, a validated and reliable self-report measure of online vigilance was developed. In combination, the results suggest that the Online Vigilance Scale (OVS) shows a stable factor structure in various contexts and user populations and provides future work i…
pBrain: A novel pipeline for Parkinson related brain structure segmentation
2020
[EN] Parkinson is a very prevalent neurodegenerative disease impacting the life of millions of people worldwide. Although its cause remains unknown, its functional and structural analysis is fundamental to advance in the search of a cure or symptomatic treatment. The automatic segmentation of deep brain structures related to Parkinson's disease could be beneficial for the follow up and treatment planning. Unfortunately, there is not broadly available segmentation software to automatically measure Parkinson related structures. In this paper, we present a novel pipeline to segment three deep brain structures related to Parkinson's disease (substantia nigra, subthalamic nucleus and red nucleus…