Search results for "Research Design"
showing 10 items of 487 documents
Genetic variants linked to myopic macular degeneration in persons with high myopia: CREAM Consortium.
2019
Purpose: To evaluate the roles of known myopia-associated genetic variants for development of myopic macular degeneration (MMD) in individuals with high myopia (HM), using case-control studies from the Consortium of Refractive Error and Myopia (CREAM). Methods: A candidate gene approach tested 50 myopia-associated loci for association with HM and MMD, using meta-analyses of case-control studies comprising subjects of European and Asian ancestry aged 30 to 80 years from 10 studies. Fifty loci with the strongest associations with myopia were chosen from a previous published GWAS study. Highly myopic (spherical equivalent [SE] ≤ -5.0 diopters [D]) cases with MMD (N = 348), and two sets of cont…
New Hepatocyte In Vitro Systems for Drug Metabolism: Metabolic Capacity and Recommendations for Application in Basic Research and Drug Development, S…
2003
Primary hepatocytes represent a well-accepted in vitro cell culture system for studies of drug metabolism, enzyme induction, transplantation, viral hepatitis, and hepatocyte regeneration. Recently, a multicentric research program has been initiated to optimize and standardize new in vitro systems with hepatocytes. In this article, we discuss five of these in vitro systems: hepatocytes in suspension, perifusion culture systems, liver slices, co-culture systems of hepatocytes with intestinal bacteria, and 96-well plate bioreactors. From a technical point of view, freshly isolated or cryopreserved hepatocytes in suspension represent a readily available and easy-to-handle in vitro system that c…
Reporting guidelines for health research: protocol for a cross-sectional analysis of the EQUATOR Network Library
2019
© Author(s) (or their employer(s)) 2019.
The categorization of amateur cyclists as research participants: findings from an observational study.
2018
Sampling bias is an issue for research involving cyclists. The heterogeneity of cyclist populations, on the basis of skill level and riding purpose, can generate incorrect inferences about one specific segment of the population of interest. In addition, a more accurate categorization would be helpful when physiological parameters are not available. This study proposes using self-reported data to categorize amateur cyclist types by varying skill levels and riding purposes, therefore improving sample selection in experimental studies. A total of 986 cyclists completed an online questionnaire between February and October 2016. Two-step cluster analyses were performed to generate distinct group…
Studying the User Experience in Online Banking Services: An Eye-Tracking Application
2019
Abstract Neuromarketing as research method contrbutes to understanding consumer behavior a step further than traditional marketing research. The aim of the current study is to explore the usability and cognitive understanding of banking services webpages. In this regard, the theoretical part of the article reviews the relevant literature related to neuromarketing as research method and the use of eye-tracker as research technique. Further on, a two-step research design was developed for studying the consumers’ attention and memory during and after viewing two Romanian banking services websites. The results showed that the way information is structured and presented on the webpages influence…
Comparison Between Classic and Light Touch Massage on Psychological and Physical Functional Variables in Athletes: a Randomized Pilot Trial
2020
Background: Despite the general belief of the benefits and the widespread use of massage in sport field, there are limited empirical data on possible effectiveness of massage on psychological and physical functional variables.
 Purpose: The main objective of the present study was to compare the effectiveness of classical and light touch massage on psychological and physical functional variables in athletes.
 Setting: Athletic club of Valencia
 Participants: 20 amateur athletes were recruited from two athletic clubs.
 Research Design: A single-blind, randomized, pilot-placebo trial.
 Intervention: The subjects were randomly allocated to two different groups: a) Massa…
The Relationship of Sexism and Gender Ideology to Self-Concept and Self-Esteem in Persons with Spinal Cord Injury
2017
The process of adapting to a physical disability is complex and multi-dimensional. It is influenced by many variables that affect adequate life adjustment and psychological wellbeing. This study addresses the specific effects of sexism and gender stereotypes on self-esteem and selfconcept in persons with spinal cord injury (SCI). The research design is cross-sectional and correlational. The sample comprises 127 persons, including 95 men and 32 women, with a long-term spinal injury. The results of the MANOVAs do not demonstrate statistically significant differences based on sex for the following variables: self-esteem, self-concept, traditional sexism and neosexism. The relationships among v…
Rationale, study design, and analysis plan of the Alveolar Recruitment for ARDS Trial (ART): study protocol for a randomized controlled trial.
2012
Abstract Background Acute respiratory distress syndrome (ARDS) is associated with high in-hospital mortality. Alveolar recruitment followed by ventilation at optimal titrated PEEP may reduce ventilator-induced lung injury and improve oxygenation in patients with ARDS, but the effects on mortality and other clinical outcomes remain unknown. This article reports the rationale, study design, and analysis plan of the Alveolar Recruitment for ARDS Trial (ART). Methods/Design ART is a pragmatic, multicenter, randomized (concealed), controlled trial, which aims to determine if maximum stepwise alveolar recruitment associated with PEEP titration is able to increase 28-day survival in patients with …
Positive family history of colorectal cancer in a general practice setting [FRIDA.Frankfurt]: study protocol of a of a cross-sectional study.
2015
Background Although the risk of developing colorectal cancer (CRC) is 2-4 times higher in case of a positive family history, risk-adapted screening programs for family members related to CRC- patients do not exist in the German health care system. CRC screening recommendations for persons under 55 years of age that have a family predisposition have been published in several guidelines. The primary aim of this study is to determine the frequency of positive family history of CRC (1st degree relatives with CRC) among 40–54 year old persons in a general practitioner (GP) setting in Germany. Secondary aims are to detect the frequency of occurrence of colorectal neoplasms (CRC and advanced adeno…
Cost analysis of the flash monitoring system (FreeStyle Libre 2) in adults with type 1 diabetes mellitus
2020
IntroductionCompare cost of the interstitial liquid glucose flash monitoring (FM) system (FreeStyle Libre 2) versus self-monitoring of blood glucose (SMBG) in adults with type 1 diabetes mellitus (T1DM) in Spain.Research design and methodsA model was developed to estimate, with the perspective of the Spanish health system, the annual costs associated with glucose monitoring and hypoglycemic events management in T1DM population, with multiple insulin daily doses (MDI). According to published evidence, rate of severe hypoglycemia (SHE) of 4.90 episodes per patient-year was applied. Reduction of SHE (58.6%) was modeled associated with FM use. Published rates of hospital care (20.2%) and subseq…