Search results for "Residual"

Predictive Factors for Outcome of First Allogeneic Transplant for Elderly Patients With Acute Lymphoblastic Leukemia

2021

Abstract Introduction/Background: The treatment of acute lymphoblastic leukemia (ALL) in patients older than 70 is extremely challenging with dismal outcome. Allogeneic stem cell transplantation (alloHCT) has seen many advancements in the last decades showing benefits in younger ALL patients, but this treatment modality is decreasingly used with increasing age due to high treatment-related mortality. Patients and Methods: We identified 84 ALL patients 70 to 84 years old allografted In 2002 to 2019 from a matched related (23%), unrelated (58%), haploidentical (17%), or cord blood (2%) donor at EBMT participating centers with a median follow-up of 23 months. Results: The 2-year relapse incide…

68 O - Maintenance low-dose (LD) oral idarubicin (oIDA) in elderly patients (pts) with acute myelogeneous leukemia (AML)

1996

IDA by i.v. route. especially in combination with cytosine arabinoside (Ara-C). proved quite effective for intensive chemotherapy of AML However, persisting controversies on aggressive/intensive versus “ottenvated” regimens for elderly AML pts emphasize the interest of olDA in this latter setting (ct M.R. Howard et al and M.J. Keating. Clin. Drug Invest. 1995; 9. Suppl. 2: 16–38) A 69% complete response (CR) rate was recentty reported (F. Leoni et al Br. J. Hoematol 1995; 90: 169–174) among 25 elderly AML pts (> 60 yrs old) with an “attenuated” dose of IDA, i.e. 8 mg/m2 i.v. d, 1. 3, and 5. plus Ara-C 200 mg/m2 by continuous i.v. infusion (ClV) d, 1–7, and etoposide (VP-16) 60 mg/m2 i.v. d,…

FIRST APPLICATION OF MINIMAL RESIDUAL DISEASE ANALYSIS IN SPLENIC MARGINAL ZONE LYMPHOMA TRIALS: PRELIMINARY RESULTS FROM BRISMA/IELSG36 PHASE II STU…

2019

Optimal duration of low molecular weight heparin for the treatment of cancer-related deep vein thrombosis. The ”CANCER DACUS” study

2014

Purpose We evaluated the role of residual vein thrombosis (RVT) to assess the optimal duration of anticoagulants in patients with cancer who have deep vein thrombosis (DVT) of the lower limbs. Patients and Methods Patients with active cancer and a first episode of DVT treated with low molecular weight heparin (LMWH) for 6 months were eligible. Patients were managed according to RVT findings: those with RVT were randomly assigned to continue LMWH for an additional 6 months (group A1) or to discontinue it (group A2), and patients without RVT stopped LMWH (group B). The primary end point was recurrent venous thromboembolism (VTE) during the 1 year after disconinuation of LMWH, and the secondar…

Measurement of Mechanical Properties of Cantilever Shaped Materials

2008

Microcantilevers were first introduced as imaging probes in Atomic Force Microscopy (AFM) due to their extremely high sensitivity in measuring surface forces. The versatility of these probes, however, allows the sensing and measurement of a host of mechanical properties of various materials. Sensor parameters such as resonance frequency, quality factor, amplitude of vibration and bending due to a differential stress can all be simultaneously determined for a cantilever. When measuring the mechanical properties of materials, identifying and discerning the most influential parameters responsible for the observed changes in the cantilever response are important. We will, therefore, discuss the…

Optimal Pre-Oxygenation: The Nasoral-System

1994

The human body’s intra-and extrapulmonary O2 reserves, i.e. the oxygen stores of the functional residual capacity (FRC) and the blood, will be rapidly depleted during any kind of respiratory arrest (apnea). Application of oxygen prior to iatrogenic apnea (e.g. for endotracheal intubation procedures), therefore, commonly is discussed [e.g. Miller, 1990] as the proposed measure designed to achieve an increase in the human body’s oxygen stores sufficient to avoid hypoxemia. This prophylactic application of oxygen simply has become to be termed “pre-oxygenation”, regardless of the amount of increase in the O2 stores actually achieved. A myriad of different techniques and procedures are practica…

Hydraulic conductivity and strength of pervious concrete for deep trench drains

2019

Abstract Pervious concrete for deep trench drains, used to stabilise slopes, must meet many requirements, namely, adequate hydraulic conductivity, adequate shear strength a few days after pouring, capacity to act as a protective filter for soils in which the drain is installed, good resistance to clogging and adequate residual hydraulic conductivity. In current engineering practice, the composition of pervious concrete for drains is improperly selected according to criteria used for no-fines concrete for road pavements. To detect more suitable and specific criteria, a laboratory investigation has been conducted aimed at identifying the composition and the properties of pervious concrete sat…

Negative ions and their importance for the analysis of residual gas

1963

Abstract In the case of heavy molecules, mass spectre obtained with the help of positive ions generally lead to the recording of fragments only, and thus do not indicate the true original mass. In order to overcome this drawback, an attempt was made to attach slow electrons to heavy molecules, since less dissociation products are expected with spectre produced by negative ions. As a preliminary experiment, a simple and cheap form of ion source was constructed which produces mainly atomic negative ions.

Pediatric Anaplastic Large Cell Lymphoma with Concomitant Involvement of Spine and Central Nervous System: A Case Report and Review of Literature

2021

Anaplastic large cell lymphoma (ALCL) is a histological subtype of non-Hodgkin lymphoma, largely characterized by anaplastic lymphoma kinase (ALK) positivity, resulting from the chromosomal translocation t(2;5). We report a pediatric case of ALK-positive ALCL with primary concomitant involvement of bone and central nervous system (CNS); thereafter, a literature review about pediatric primary bone and primary CNS ALCL was conducted. According to the analyzed data, our case is unique because it is characterized by the contemporary involvement of the spine and CNS. During and after chemotherapy, our patient was monitored by detecting minimal residual disease (MRD) through the analysis of fusio…

Numerical modelling of fatigue crack initiation of martensitic steel

2010

Numerical simulation of micro-crack initiation that is based on Tanaka-Mura micro-crack nucleation model is presented. Three improvements were added to this model. Firstly, multiple slip bands where micro-cracks may occur are used in each grain. Second improvement deals with micro-crack coalescence by extending existing micro-cracks along grain boundaries and connecting them into a macro-crack. The third improvement handles segmented micro-crack generation, where a micro-crack is not nucleated in one step like in Tanaka-Mura model, but is instead generated in multiple steps. Numerical simulation of crack-initiation was performed with ABAQUS, using a plug-in that was written specially for ha…