Search results for "Residual"

Friction Stir Welding of Ti6Al4V complex geometries for aeronautical applications: a feasibility study

2020

Abstract While Friction Stir Welding (FSW) of aluminium alloys can be considered a mature technology, even for complex joint morphologies, as T joints welded “in transparency”, welding of hard material still presents several open issues. In fact, welding of titanium alloys is a challenging process due to the chemical, mechanical and thermal characteristics of such materials which are subjected to atmosphere contamination resulting in joint hydrogen, oxygen and nitrogen embrittlement; additionally, due to the high melting temperature, large distortion and residual stress are found in joints obtained by traditional fusion welding processes as gas metal arc welding, electron beam welding and l…

Influence of residual stress, surface roughness and crystallographic texture induced by machining on the corrosion behaviour of copper in salt-fog at…

2012

International audience; The influence of quadratic stress, crystallographic texture, lubrication and surface roughness generated by superfinish turning on the corrosion behaviour of pure copper was quantified in salt-fog atmosphere. This was done using statistical analysis (Pearson's correlation matrix). Three compounds were found after corrosion tests: atacamite/paratacamite and a black layer (mixture of the lubricant and the salt atmosphere). Surface characteristics were classified according to their decreasing influence on the formation of atacamite/paratacamite as follows: surface roughness and quadratic stress. Lubrication and the crystallographic texture have the lowest influence on c…

Impact des conditions d'usinage sur la zone du matériau affectée par le procédé

2007

Colloque avec actes et comité de lecture. Internationale.; International audience; Les procédés d'usinage peuvent créer des contraintes résiduelles à la surface des pièces usinées et ainsi modifier la microstructure et la texture de la matière proche de la surface. De tels changements sont importants pour l'étude du comportement des pièces au cours du temps. Il est alors nécessaire de quantifier les contraintes résiduelles, les composantes de texture et de déterminer la microstructure induite par l'usinage pour comprendre et prédire le comportement des surfaces considérées. Dans cette étude, le matériau cuivre pur a été choisi et considéré comme un "système modèle". En tournage, l'influence…

Identification of Objects Based on Generalized Amplitude-Phase Images Statistical Models

2017

The article presents the dynamical objects identification technology based on statistical models of amplitude-phase images (APIm) – multidimensional data arrays (semantic models) and statistical correlation analysis methods using the generalized discrete Hilbert transforms (DHT) – 2D Hilbert (Foucault) isotropic (HTI), anisotropic (HTA) and total transforms – AP-analysis (APA) to calculate the APIm. The identified objects are modeled with 3D airplanes templates rotated in space around the center of Cartesian coordinate system. The DHT domain system of coordinates displaying the plane projections (2D flat images) remains to be space-invariant. That causes the anisotropic properties of APIm a…

The minimum mean cycle-canceling algorithm for linear programs

2022

Abstract This paper presents the properties of the minimum mean cycle-canceling algorithm for solving linear programming models. Originally designed for solving network flow problems for which it runs in strongly polynomial time, most of its properties are preserved. This is at the price of adapting the fundamental decomposition theorem of a network flow solution together with various definitions: that of a cycle and the way to calculate its cost, the residual problem, and the improvement factor at the end of a phase. We also use the primal and dual necessary and sufficient optimality conditions stated on the residual problem for establishing the pricing step giving its name to the algorith…

On the reactivation of a large landslide induced by rainfall in highly fissured clays

2018

Abstract The paper discusses the field investigations, geotechnical characterization and time evolution of horizontal displacements in a wide landslide. The latter, triggered by an earthquake occurring in September 2002, is located in Sicily and involves a thick body of stiff and highly fissured clays belonging to a Varicoloured Clay formation. In order to characterise the reactivation of landslide mechanisms induced by rainfall, a three-year monitoring programme (2008–2011) was implemented to measure rain, pore water pressures, and deep and superficial displacements. The monitoring data made it possible to recognize three distinct landslides, which evolve at variable rates in different dir…

Is preoxygenation still important? New concepts

2017

Patient-individualized CD8+cytolytic T-cell therapy effectively combats minimal residual leukemia in immunodeficient mice

2015

Adoptive transfer of donor-derived cytolytic T-lymphocytes (CTL) has evolved as a promising strategy to improve graft-versus-leukemia (GvL) effects in allogeneic hematopoietic stem-cell transplantation. However, durable clinical responses are often hampered by limited capability of transferred T cells to establish effective and sustained antitumor immunity in vivo. We therefore analyzed GvL responses of acute myeloid leukemia (AML)-reactive CD8(+) CTL with central and effector memory phenotype in a new allogeneic donor-patient specific humanized mouse model. CTL lines and clones obtained upon stimulation of naive CD45RA(+) donor CD8(+) T cells with either single HLA antigen-mismatched or HL…

Circulating Tumor DNA Detection by Digital-Droplet PCR in Pancreatic Ductal Adenocarcinoma: A Systematic Review

2021

Simple Summary Pancreatic cancer is a digestive tumor that is most difficult to treat and carries one of the worst prognoses. The anatomical location of the pancreas makes it very difficult to obtain enough tumor material to establish a molecular diagnosis, so knowing the biology of this tumor and implementing new targeted-therapies is still a pending issue. The use of liquid biopsy, a blood sample test to detect circulating-tumor DNA fragments (ctDNA), is key to overcoming this difficulty and improving the evolution of this tumor. Liquid biopsies are equally representative of the tissue from which they come and allow relevant molecular and diagnostic information to be obtained in a faster …

Ibrutinib, obinutuzumab, and venetoclax in relapsed and untreated patients with mantle cell lymphoma: a phase 1/2 trial.

2020

Abstract Ibrutinib, obinutuzumab, and venetoclax demonstrate synergy in preclinical models of mantle cell lymphoma (MCL). OAsIs (NCT02558816), a single-arm multicenter prospective phase 1/2 trial, aimed to determine the maximum tolerated dose of venetoclax in combination with fixed doses of ibrutinib and obinutuzumab, in relapsed MCL patients. At the venetoclax MTD, extension cohorts were opened for relapsed and untreated patients. Safety and efficacy were secondary objectives. Minimal residual disease (MRD) was assessed by allele-specific oligonucleotide quantitative polymerase chain reaction. Between 14 October 2015 and 29 May 2018, 48 patients were enrolled. No dose-limiting toxicity was…