Search results for "Residual"
showing 10 items of 554 documents
Retinoic-Acid-Induced Downregulation of the 67 KDa Laminin Receptor Correlates with Reduced Biological Aggressiveness of Human Neuroblastoma Cells
2012
Neuroblastoma is a common tumor of the childhood arising from embryonal sympathetic neural cell precursors. Despite of the improved therapeutic strategies, the survival rate of high-risk neuroblastoma patients is poor. Although complete clinical remissions can be achieved, relapse is relatively frequent, indicating a role for the persistence of the minimal residual disease (for review, Maris, 2010). Treatments with derivatives of retinoic acid (RA), the biologically active form of vitamin A, produce significant improvements on the therapy of high-risk neuroblastoma patients, when used together with intensive multimodal therapies (Reynolds et al., 2003, for review). Despite some controversy …
Estudio de la enfermedad residual mínima en pacientes con mieloma múltiple en muy buena respuesta parcial o completa convencional mediante citometría…
2021
El mieloma múltiple (MM) es una gammapatía monoclonal maligna caracterizada por la proliferación clonal de células plasmáticas patológicas (CPP) en la médula ósea (MO) o, con menos frecuencia, en lesiones extramedulares. Tradicionalmente, la evaluación de la respuesta al tratamiento en el MM se ha realizado mediante la cuantificación del componente monoclonal (CM) en suero y la presencia de CPP en MO, siendo la desaparición de ambas cosas la definición de una respuesta completa (RC). Sin embargo, la mayoría de estos pacientes que alcanzan RC, siguen sufriendo recaídas debido a la denominada enfermedad residual mínima (ERM). Recientemente, en el marco de ensayos clínicos, se ha demostrado qu…
Estudio del tratamiento anaerobio de aguas residuales urbanas en biorreactores de membranas
2014
Las aguas residuales urbanas (ARU) constituyen la fuente puntual de contaminantes más importante a escala global. Actualmente, un elevado porcentaje de las aguas residuales producidas a nivel mundial son vertidas al medio sin haber recibido ningún tipo de tratamiento, con consecuencias inmediatas, y en algunas ocasiones desastrosas, para la salud pública y la calidad del entorno natural. El tratamiento anaerobio está considerado como una de las alternativas más atractivas para el desarrollo de sistemas sostenibles de tratamiento de aguas residuales que ayuden a mitigar los efectos negativos de la urbanización y del desarrollo socioeconómico. El atractivo de estos sistemas reside en su mayor…
Emisiones difusas: medidas experimentales y modelización aplicadas a instalaciones de tratamiento de aguas residuales
2015
Los olores emitidos por la actividad rutinaria de una planta de tratamiento de aguas residuales (EDAR) representan una importante fuente de molestia medioambiental que, por lo general, implica la liberación atmosférica de sustancias que causan mal olor y problemas de salud asociados. Actualmente, existe una preocupación pública sobre los olores que se generan con trabajos de tratamiento de residuos. Esta preocupación ha aumentado en la última década debido principalmente a la sobrecarga en las zonas de captación y la invasión de núcleos habitados en torno a instalaciones de tratamiento de aguas residuales (reduciendo los márgenes de seguridad impuestos a éstos). Estas potenciales emisiones …
Quantification of LAI interannual anomalies by adjusting climatological patterns
2011
International audience; Scaling variations and shifts in the timing of seasonal phenology are central features of global change research. In this study, we propose a novel climatology fitting approach to quantify inter-annual anomalies in LAI seasonality. A consistent archive of daily LAI estimates was first derived from historical AVHRR satellite data for the 1981-2000 period over a globally representative sample of sites. The climatology values were then computed by averaging multi-year LAI profiles, gap filling and smoothing to eliminate possible high temporal frequency residual artifacts. The inter-annual variations in LAI were finally quantified by scaling and shifting the seasonal cli…
Residual errors in ASTER temperature and emissivity standard products AST08 and AST05
2011
Abstract Land surface temperature and emissivity are independent variables, and the thermal-infrared spectral radiance measured in remote sensing is dependent on both. Therefore the inverse Planck equation is under-determined, with two unknowns and a single measurement. Practical inversion algorithms designed to calculate temperature and emissivity from the measurements cannot do a perfect job of separation, and recovered temperature and emissivity may co-vary. For ASTER images, validation studies of recovered temperature and emissivity, regarded individually, have shown that they are within the precision and accuracy limits predicted in designing the ASTER TES algorithm used to calculate …
Obtención de los principales parámetros del agua residual urbana empleados en los modelos matemáticos de fangos activados a partir de una caracteriza…
2017
El tratamiento de las aguas residuales se ha realizado en España mediante procesos biológicos como el comúnmente utilizado de fangos activados. Estos procesos han sido descritos mediante modelos matemáticos que describen la eliminación de los contaminantes presentes en el agua (materia orgánica, nitrógeno y fósforo). La utilización de estos modelos requiere de una caracterización detallada de los contaminantes presentes en el agua residual urbana (ARU). La caracterización de un ARU es clave para el uso de estos modelos de simulación, tanto en el diseño como en la simulación de las Estaciones Depuradoras de Aguas Residuales (EDAR). Este trabajo ha utilizado y considerado los parámetros propu…
Daily evapotranspiration assessment by means of residual surface energy balance modeling: A critical analysis under a wide range of water availability
2012
Summary An operational use of the actual evapotranspiration assessed by remote sensing approaches requires the integration of instantaneous fluxes to daily values. This is commonly achieved under the hypotheses of daytime self-preservation of evaporative fraction and negligible daily ground heat flux. The aim of this study is to evaluate the effect of these assumptions on estimate daily evapotranspiration over a full phenological cycle, including phases characterized by significant changes both in net radiation and vegetation cover. To assess the reliability of these hypotheses, the observations made by a flux tower, installed within a homogeneous field of cereal located in the valley part …
Applications of a remote sensing-based two-source energy balance algorithm for mapping surface fluxes without in situ air temperature observations
2012
Abstract The two-source energy balance (TSEB) model uses remotely sensed maps of land–surface temperature (LST) along with local air temperature estimates at a nominal blending height to model heat and water fluxes across a landscape, partitioned between dual sources of canopy and soil. For operational implementation of TSEB, however, it is often difficult to obtain representative air temperature data that are compatible with the LST retrievals, which may themselves have residual errors due to atmospheric and emissivity corrections. To address this issue, two different strategies in applying the TSEB model without requiring local air temperature data were tested over a typical Mediterranean…
Towards More Specificity and Effectivity in the Antileukemia Immune Response
2014
Experimental and clinical studies have shown that alloreactive T-cell responses derived from donor lymphocytes can effectively eliminate leukemia cells after allogeneic hematopoietic stem cell transplantation. However, there are still too many patients in whom this graft-versus-leukemia reactivity is insufficient to prevent leukemia relapse or who suffer from severe alloreactivity to nonmalignant host tissues also mediated by donor-derived T cells. Therefore, various conceptually different approaches have been developed at the level of donor T cells in order to improve the efficacy of leukemia-directed immunity while reducing the incidence of unwanted graft-versus-host disease. As outlined …