Search results for "Response surface method"

Optimization of a LC method for the enantioseparation of a non-competitive glutamate receptor antagonist, by experimental design methodology

2006

Abstract The aim of this work was to obtain the direct optical resolution of a new glutamate receptor antagonist (( p -chloro)1-aryl-6,7,-dimethoxy-1,2,3,4-tetrahydroisoquinoline, PS3), by liquid chromatography on Chiralcel ® OD column. A response surface methodology (RSM) was employed to optimize the enantiomeric separation of the racemate with the lowest number of experiments; in particular, a face-centred design (FCD) was applied to evaluate the influence of critical parameters on the experimental response. Furthermore, in order to find the best compromise between several responses, a multicriteria decision-making approach, the Derringer's desirability function, was successful to simulta…

An optimization procedure for the friction stir welding FEM model of corner fillet joints

2012

Friction stir welding (FSW) is an energy efficient and environmentally "friendly" (no fumes, noise, or sparks) welding process, during which the sheets are welded together in a solid-state joining process. FSW is mature for simple configurations but a significant lack of knowledge is found when dealing with different designs such as T-sections, box sections and corner welds. Although the latter joint morphology has traditionally been considered unfeasible for the process, it seems to have a great potential to be used also for T-joint configurations, a recurrent design pattern in transport applications. A specific tool has been developed and a set of experimental welds has been produced with…

Tecniche di ottimizzazione multi-obiettivo e metodologie di supporto alle decisioni per la progettazione di processi di stampaggio di lamiere

2010

Analysis of stamping performances of dual phase steels: A multi-objective approach to reduce springback and thinning failure

2009

The industrial interest on light weight components has contributed in the last years to a significant research effort on new materials able to guarantee high mechanical properties, good formability and reasonable costs together with reduced weights when compared to traditional mild steels. Among such materials advanced high strength steels (AHSS) such as transformations induced plasticity (TRIP) and dual phase (DP), and light weight alloys proved their usefulness in stamping of automotive components. As AHSS are concerned, one of the main drawbacks is related to springback occurrence. Many aspects have to be taken into account when springback reduction is investigated: material behavior iss…

Purification of recovered phosphoric acid by extracting aluminium with di-2-ethylhexyl phosphoric acid

2021

AbstractThe extraction of aluminium from dilute phosphoric acid with di-2-ethylhexyl phosphoric acid (DEHPA) was optimized using response surface methodology. The optimization was based on the experimental three-level central composite face-centred design (CCF) and was conducted on real-life samples. The three variables included were pH, extractant concentration and aqueous to organic phase ratio (AO). Under the optimized conditions (pH 2.5, 0.6 M DEHPA and AO ratio 1:2), extraction efficiency of 99% for aluminium in four extraction stages is achieved. The purified phosphoric acid solution can then be utilized by the fertilizing industry. Stripping tests for organic phase loaded with alumin…

Optimization of Polyphenols' Recovery from Purple Corn Cobs Assisted by Infrared Technology and Use of Extracted Anthocyanins as a Natural Colorant i…

2022

An ecofriendly extraction technology using infrared (IR) irradiation Ired-Irrad® was applied to purple corn cobs to enhance polyphenol recovery for the first time. The IR extraction efficiency was compared to that of the water bath (WB) method. Response surface methodology (RSM) using a central composite design was conducted to determine the effect of the experimental conditions (extraction time and treatment temperature) and their interactions on the total polyphenol and anthocyanin yields. Optimal extraction of total phenolic compounds (37 mg GAE/g DM) and total monomeric anthocyanins (14 mg C3G/g DM) were obtained at 63 °C for 77 min using IR as an extraction technique and water as a sol…

Efficient extraction and preparative separation of four main isoflavonoids from Dalbergia odorifera T. Chen leaves by deep eutectic solvents-based ne…

2016

In this study, green and efficient deep eutectic solvent-based negative pressure cavitation-assisted extraction (DES-NPCE) followed by macroporous resin column chromatography was developed to extract and separate four main isoflavonoids, i.e. prunetin, tectorigenin, genistein and biochanin A from Dalbergia odorifera T. Chen leaves. The extraction procedure was optimized systematically by single-factor experiments and a Box-Behnken experimental design combined with response surface methodology. The maximum extraction yields of prunetin, tectorigenin, genistein and biochanin A reached 1.204, 1.057, 0.911 and 2.448mg/g dry weight, respectively. Moreover, the direct enrichment and separation of…

On the self-heating behavior of upgraded biochar pellets blended with pyrolysis oil: Effects of process parameters

2020

Abstract Biochar obtained from biomass pyrolysis is a promising carbon neutral material which can be used in substitution of fossil coal and coke in metallurgical applications. Biochar’s mechanical properties improve significantly without compromising reactivity, when upgraded by densification with pyrolysis oil and reheated. However, upgraded biochar pellets use in the industry is limited due to the risks associated with self-heating. This issue must be seriously considered for further industrial production of upgraded biochar pellets. Self-heating oven tests are generally time-consuming and limit the possibility of testing various potential solutions. The aim of this work was both to inve…

On the Moving Least Squares (MLS) approximation effectiveness in a T-Shaped tube hydroforming design

2009

High pressure processing of fruit juice mixture sweetened with Stevia rebaudiana Bertoni: Optimal retention of physical and nutritional quality

2013

Abstract The impact of high pressure processing (HPP) technology on physicochemical properties (color, browning index, turbidity index), bioactive compounds (ascorbic acid, total phenolic compounds, total anthocyanins, total carotenoids) and antioxidant capacity of a fruit juice mixture (papaya (32.5%, v/v), mango (10%, v/v) and orange (7.5%, v/v)) sweetened with Stevia rebaudiana Bertoni at different percentages was studied. The experimental design comprised a response surface methodology according to a central composite face-centered design. The variable ranges were 300–500 MPa (pressure), 5–15 min (time), 0–2.5% Stevia percentage. This design was used to determine the optimal high pressu…