Search results for "Response"

showing 10 items of 4136 documents

Blood Vessel Detection Algorithm for Tissue Engineering and Quantitative Histology.

2021

AbstractImmunohistochemistry for vascular network analysis plays a fundamental role in basic science, translational research and clinical practice. However, identifying vascularization in histological tissue images is time consuming and markedly depends on the operator’s experience. In this study, we present “blood vessel detection—BVD”, an automatic algorithm for quantitative analysis of blood vessels in immunohistochemical images. BVD is based on extraction and analysis of low-level image features and spatial filtering techniques, which do not require a training phase. BVD algorithm performance was comparatively evaluated on histological sections from three different in vivo experiments. …

Settore ING-INF/05 - Sistemi Di Elaborazione Delle InformazioniNeovascularization PathologicTissue EngineeringBiomedical EngineeringImage Processing Computer-AssistedSettore ING-IND/34 - Bioingegneria IndustrialeHumansAngiogenesis Automated image analysis Biomaterials host response Blood vessel formation Blood vessel morphology Quantitative histology Quantitative immunohistochemistry VascularizationImmunohistochemistryAlgorithmsAnnals of biomedical engineering
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Il delitto di "caporalato" tra diritti minimi della persona e tutela del mercato del lavoro

2020

Il contributo analizza il reato di intermediazione illecita e sfruttamento lavorativo, offrendo un’analisi comparata con il sistema repressivo tedesco. Lo studio si sofferma, in particolare, sui limiti di legittimazione del diritto penale nella punizione dei fatti di “caporalato”, nel tentativo di scongiurare che l’intervento repressivo nelle dinamiche economiche e contrattuali, di natura sinallagmatica, possa assumere una portata tale da porsi in contrasto con il canone della sussidiarietà. A tal fine, si suggerisce una prospettiva ermeneutica che incentri il disvalore penale del reato di cui all’art. 603-bis c.p. sulla lesione dei diritti fondamentali del lavoratore – riconducibili agli a…

Settore IUS/17 - Diritto PenaleThe paper analyses the offence of unlawful work intermediation and exploitation offering a comparative analysis with the German punitive system. The study focuses in particular on the limits of legitimacy of criminal law in the punishment of gangmaster acts in the attempt to avoid that the punitive intervention in economic and contractual dynamics of a mutual nature could be so intrusive to be in contrast with the principle of subsidiarity. To this end the author suggests an interpretative perspective that centres the penal disvalue of the offence under article 603-bis of the criminal code on the harm to fundamental workers’ rights – as linked to articles 4 35 and 36 of the Italian Constitutions – which work as a limit to entrepreneurial freedom. To be sure the indexes of exploitation listed by the criminalising norm seem to echo those fundamental human rights attributed to a person as a worker: those very same rights that – when harmed in their minimal and therefore intangible dimension – legitimise the intervention of the ius terribile. The article also stresses the protection of the job market: in this sense the offence – even if situated within the Kernstrafrecht – represents a new paradigm of the institutional response within the framework of the contemporary relationships between law and economics.
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Eminentissimae foeminae: la dinastia giulio-claudia vista dalla Sicilia

2019

The paper deals with the portraits of the female members of the Julio-Claudian dynasty that were found in Sicily (Tyndaris, Thermae Himeraeae, Solunto, Centuripe, Syracuse, Catania, ?Lipari) and in the surrounding small islands (Pantelleria/S. Teresa, Malta/Rabat, Gozo/Victoria). In addition to some portrait heads, a series of lesser known pieces, among which several fragments of iconic statues, rather neglected till now, are discussed. Iconography, associations and contexts are considered in order to assess the messages and functions of the statues, and the role these images played in the cultural discourse.

Settore L-ANT/07 - Archeologia ClassicaRoman Sicily Julio-Claudians Portraiture Imperial ideology and local response
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Ancora sulle "esplosive palatali" nelle inchieste dell'Atlante Linguistico del Mediterraneo (ALM): i punti albanesi

2021

Tra i «Problemi redazionali» emersi in fase di controllo e organizzazione dei materiali giunti dalla campagna di rilevamenti dell’Atlante Linguistico del Mediterraneo (ALM), Berruto (1971-1973) rileva la proliferazione e l’eterogeneità di alcune scelte grafemiche operate da diversi raccoglitori che, impegnati in una trascrizione più o meno puntuale delle risposte ottenute, avevano interpretato e risolto variamente alcune delle indicazioni previste nel sistema di trascrizione fonetica che accompagnava il Questionario. Particolarmente complesso era emerso il quadro relativo alla trascrizione di alcune consonanti del settore “palatale”, per le quali i grafemi (e i foni a essi corrispondenti) p…

Settore L-FIL-LET/12 - Linguistica ItalianaAmong the «Editorial problems» that emerged during the control and organization of the materials coming from the survey campaign of the Atlante Linguistico del Mediterraneo (ALM) Berruto (1971-1973) notes the proliferation and heterogeneity of some graphemic choices made by different field researchers. As they were engaged in a more or less punctual transcription of the answers obtained they had interpreted and solved differently some of the directions provided in the phonetic transcription system that accompanied the Questionnaire. The picture relating to the transcription of some consonants of the palatal sector had emerged as particularly complex since the graphemes (and the corresponding phones) foreseen in the original system (ALM 1959) were insufficient. Not even the 1971 updates meant to improve the representation of some phonetic features emerged from the investigations in the operations of Response reviewing allowed to obtain a clear homogeneous picture regarding the «plosive palatal» consonants. With regard to the phonetic trait under scrutiny I have already had the opportunity to propose a path aiming to the achievement of possible operational solutions. This has taken place in view of the planned simplification / homologation and transcoding phase from the ALM original system to the IPA one - while proceeding from the examination of the Schedoni’s current state with regard to the surveys referring to central-southern Italy Corsica and Sicily (see Matranga 2019). The scope is now to investigate the same phonetic trait as proven in the materials about the surveys carried out by Lirak Dodbiba in the ALM’s three Albanian points.
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Centenarians born before 1919 are resistant to COVID-19.

2022

Although mortality from COVID-19 progressively increases with age, there are controversial data in the literature on the probability of centenarians dying from COVID-19. Moreover, it has been claimed that men in their 90s and 100s are more resilient than women. To gain insight into this matter, we analysed, according to gender, mortality data during the first year of pandemic of Sicilian nonagenarians and centenarians. We used mortality data from the 2019 as a control. The crude excess mortality between the two years was calculated. Data on deaths of Sicilian 90 + years show that, in line with what is known about the different response to infections between the two genders, oldest females a…

Settore MED/04 - Patologia GeneraleAgingCentenariansCOVID-19GenderImmune responsesSpanish FluGeriatrics and GerontologyAging clinical and experimental research
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Poly-functional immune response in HIV infection: a correlation between immunological and clinical status

2015

Aim: We analysed patient immunological status and serum cytokine profile to establish immune-activation state and afterwards the obtained data were correlated to viral activity and ARV therapy. Materials and Methods: 50 HIV-1 mono-infected patients (pt) were recruited: 5 naïve, 5 virologic controllers, 10 virologic non controllers (ARV drug-untreated pt with HIV viremia above 10,000 copies/ml), 20 virologic responders (ARV drug-treated pt with undetectable HIV viremia) and 10 virologic non responders patients (ARV drug-treated pt with HIV viremia ≥ 400 copies/ml). IFN- production and plasmatic cytokine pattern levels (IL-1β, IL-2, IL-6, TNF-β, IL-4, IL-10, IL-13, IP-10, IL-8, MIP-1 α, MIP-…

Settore MED/04 - Patologia GeneraleSettore MED/17 - Malattie InfettiveHIV infection Poly-functional immune response
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Efficacy and safety of γδT cell-based tumor immunotherapy: a meta-analysis.

2014

Vγ9Vδ2 T cells are important effector cells that may play a role in the anti-tumor immune response. Their capability to exert MHC-nonrestricted lytic activity against different tumor cells in vitro and their detection among tumor infiltrating lymphocytes in a variety of human cancers have supported the development of Vγ9Vδ2 T cell-based immunotherapy in the context of novel treatment against cancer. Accordingly, promising reports from recent clinical trials support the use of V γ9Vδ2 T cells as immunotherapeutic agents, either via adoptive transfer of ex-vivo expanded V γ9Vδ2 T cells or in vivo activation of V γ9Vδ2 T cells with compounds such as phosphoantigens or aminobisphosphonates. In …

Settore MED/04 - Patologia GeneraleVγ9Vδ2 T cells; anti-tumoral response;meta-analysis.anti-tumoral responseVγ9Vδ2 T cellmeta-analysis.
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Role of sex and age in fatal outcomes of COVID-19: women and older centenarians are more resilient.

2023

In the present paper, we have analysed the role of age and sex in the fatal outcome of COVID-19, as there are conflicting results in the literature. As such, we have answered three controversial questions regarding this aspect of the COVID-19 pandemic: (1) Have women been more resilient than men? (2) Did centenarians die less than the remaining older people? (3) Were older centenarians more resistant to SARS-CoV-2 than younger centenarians? The literature review demonstrated that: (1) it is women who are more resilient, in agreement with data showing that women live longer than men even during severe famines and epidemics; however, there are conflicting data regarding centenarian men; (2) c…

Settore MED/04 - Patologia Generalenarrative reviewOrganic ChemistryCOVID-19General MedicinemortalityCatalysisimmune responsesComputer Science ApplicationsInorganic ChemistryagelongevitysexSpanish fluPhysical and Theoretical ChemistryMolecular BiologySpectroscopyage; COVID-19; immune responses; longevity; mortality; narrative review; sex; Spanish flu
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Immune-inflammatory responses in alzheimer's disease: therapeutic implications.

2011

Settore MED/04 - Patologia Generaletherapeuthic implications.immune-inflammatory responsealzheimer's disease
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Down with the erythropoietin. Long live the erythropoietin!

2009

In recent years the use of erythropoietin has exploded, and the anaemia of patients with chronic renal failure has been practically resolved with the administration of rHuEpo (recombinant human, Erythropoietin). However, as a result of an intense commercial campaign, strong therapies with this growth hormone, prescribed to achieve surprising sporting performances, got athletes to run the risk of thrombosis and vascular accidents because of red blood cells increase. Erythropoietin represents a significant subject of research. In fact, besides the ability of stimulating erythrocyte production, it has many pleiotropic effects. Several studies allow the assertion that EPO, in different concentr…

Settore MED/09 - Medicina InternaAngiogenesisClinical BiochemistryCentral nervous systemUrodelaStimulationAthletic PerformanceBioinformaticsRegenerative MedicineRegenerative medicineDose-Response RelationshipKidney FailureDrug DiscoverymedicineErythropoietin NeuroprotectionAnimalsHumansChronicErythropoietinPharmacologyRecombinantDose-Response Relationship Drugbusiness.industrySettore MED/27 - NeurochirurgiaRegeneration (biology)CancerAnemiamedicine.diseaseRecombinant Proteinsmedicine.anatomical_structureAnemia Angiogenesis Inducing Agents Animals Athletic Performance Dose-Response Relationship; Drug Erythropoietin Erythropoietin; Recombinant Humans Kidney Failure; Chronic Regenerative Medicine UrodelaErythropoietinImmunologyMolecular MedicineKidney Failure ChronicAngiogenesis Inducing AgentsDrugbusinessmedicine.drugHormone
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