Search results for "Response"
showing 10 items of 4136 documents
Support Vector Machines Framework for Linear Signal Processing
2005
This paper presents a support vector machines (SVM) framework to deal with linear signal processing (LSP) problems. The approach relies on three basic steps for model building: (1) identifying the suitable base of the Hilbert signal space in the model, (2) using a robust cost function, and (3) minimizing a constrained, regularized functional by means of the method of Lagrange multipliers. Recently, autoregressive moving average (ARMA) system identification and non-parametric spectral analysis have been formulated under this framework. The generalized, yet simple, formulation of SVM LSP problems is particularized here for three different issues: parametric spectral estimation, stability of I…
Active Plasmonics in True Data Traffic Applications: Thermo-Optic On/Off Gating Using a Silicon-Plasmonic Asymmetric MachZehnder Interferometer
2012
We present the first system-level demonstration of an active plasmonic device in 10-Gb/s data traffic conditions. An asymmetric silicon-plasmonic Mach-Zehnder interferometer with dielectric-loaded plasmonic waveguides serving as the electrically controlled arms, operates as thermo-optic ON/OFF gating element with 2.8-mu s response time and 10.8-mW power consumption. We present the first system-level demonstration of an active plasmonic device in 10-Gb/s data traffic conditions. An asymmetric silicon-plasmonic Mach-Zehnder interferometer with dielectric-loaded plasmonic waveguides serving as the electrically controlled arms, operates as thermo-optic ON/OFF gating element with 2.8-mu s respon…
Switchable Bactericidal Effects from Novel Silica-Coated Silver Nanoparticles Mediated by Light Irradiation
2011
Here we report on the triggering of antibacterial activity by a new type of silver nanoparticle coated with porous silica, Ag@silica, irradiated at their surface plasmon resonant frequency. The nanoparticles are able to bind readily to the surface of bacterial cells, although this does not affect bacterial growth since the silica shell largely attenuates the intrinsic toxicity of silver. However, upon simultaneous exposure to light corresponding to the absorption band of the nanoparticles, bacterial death is enhanced selectively on the irradiated zone. Because of the low power density used for the treatments, we discard thermal effects as the cause of cell killing. Instead, we propose that …
Efficacy of a 12-Week Simeprevir Plus Peginterferon/Ribavirin (PR) Regimen in Treatment-Naïve Patients with Hepatitis C Virus (HCV) Genotype 4 (GT4) …
2017
Background HCV GT4 accounts for up to 20% of HCV infections worldwide. Simeprevir, given for 12 weeks as part of a 24- or 48-week combination regimen with PR is approved for the treatment of chronic HCV GT4 infection. Primary study objectives were assessment of efficacy and safety of simeprevir plus PR in treatment-naïve patients with HCV GT4 treated for 12 weeks. Primary efficacy outcome was sustained virologic response 12 weeks post-treatment (SVR12). Additional objectives included investigation of potential associations of rapid virologic response and baseline factors with SVR12. Methods This multicentre, open-label, single-arm study (NCT01846832) evaluated efficacy and safety of simepre…
UV Exposure Boosts Transcutaneous Immunization and Improves Tumor Immunity: Cytotoxic T-Cell Priming through the Skin
2010
Immunologic approaches to combat cancer aim at the induction of tumor-reactive immune responses to achieve long-term protection. In this context, we recently developed a transcutaneous immunization (TCI) method using the Toll-like receptor (TLR) 7 agonist imiquimod and a peptide epitope. Application onto intact skin induces potent cytotoxic T lymphocyte (CTL) responses and protection against transplanted tumors. The purpose of this study was to explore the effects of UV irradiation on imiquimod-based TCI. Here we show that skin exposure to low-dose UV light before TCI with imiquimod strongly boosts specific CTL responses leading to memory formation and enhanced tumor protection. Toward the …
Identification and Characterization of Stress-Responsive TAS3-Derived TasiRNAs in Melon
2019
Small interfering RNAs (siRNA) are key regulators of gene expression that play essential roles in diverse biological processes. Trans-acting siRNAs (tasiRNAs) are a class of plant-endogenous siRNAs that lead the cleavage of non-identical transcripts. TasiRNAs are usually involved in fine-tuning development. However, increasing evidence supports that tasiRNAs may be involved in stress response. Melon is a crop of great economic importance extensively cultivated in semiarid regions frequently exposed to changing environmental conditions that limit its productivity. However, knowledge of the precise role of siRNAs in general, and of tasiRNAs in particular, in regulating the response to adverse…
Selecting between Competitors in Multiplication Tasks: An Explanation of the Errors Produced by Adolescents with Learning Difficulties
1997
Two experiments were conducted in order to determine the nature of the difficulties encountered by learning disabled (LD) adolescents in the resolution of multiplication problems ( a b, where a and b vary between 2 and 9). A response production task (Experiment 1) revealed that the incorrect responses generally belonged to the table of one of the two operands, and that the order of difficulty of the problems was the same for the LDs as for normal children, adolescents, and educated adults as reported in the literature. This result suggests that the difficulties are not solely due to memory problems. Experiment 2 tested the hypothesis that these difficulties were caused by a problem in inhi…
The individuals’ interest in preventing everyday accidents and crises : A Swedish explorative study of the importance of motivation
2014
This explorative study presents an empirical examination of the connection between motivation and the measures individuals take to prevent everyday accidents and prepare for crises. Positional factors (age and gender) and situational factors (education, size of locality, and household composition) are included because the literature highlights their importance. The study used data gathered in a 2010/2011 poll of randomly selected Swedish residents aged 16–75 (N = 2000; 44.8% response rate). A factor analysis reduced the theoretical model for situational motivation (Guay, Vallerand, & Blanchard, 2000) from four to two dimensions: motivation and amotivation. Subsequent regression analyses sta…
Individual variance in responsiveness to early computerized mathematics intervention
2015
Abstract We examined the effects of short, intensive computerized intervention in early number skills for kindergarteners with poor addition skills (below 1.5 SD ). The mathematical content of the software was hierarchically organized, starting from one-to-one correspondence, comparing and ordering, and proceeding via number concept and counting to basic addition. The results showed positive within-group effects for basic addition (Wilcoxon ES ( r ) = .59), verbal counting (.56), and the Number Sets Test (.45; see Geary, Bailey, & Hoard, 2009 ). The effects remained stable over a 9-week follow-up period. However, there was no significant between-group difference in terms of gain scores as c…
Asking Sensitive Questions
2013
This article is an empirical contribution to the evaluation of the randomized response technique (RRT), a prominent procedure to elicit more valid responses to sensitive questions in surveys. Based on individual validation data, we focus on two questions: First, does the RRT lead to higher prevalence estimates of sensitive behavior than direct questioning (DQ)? Second, are there differences in the effects of determinants of misreporting according to question mode? The data come from 552 face-to-face interviews with subjects who had been convicted by a court for minor criminal offences in a metropolitan area in Germany. For the first question, the answer is negative. For the second, it is po…