Search results for "Response"
showing 10 items of 4136 documents
3′-Demethyldihydromaldoxin and dihydromaldoxin, two anti-inflammtory diaryl ethers from a Steganospora species
2012
CXCL10 (IP-10) is a highly inducible chemoattractant, which contributes to the recruitment of inflammatory cells such as macrophages and T-lymphocytes and thereby has important roles in chronic inflammatory conditions. In a search for new inhibitors of CXCL10 expression in MonoMac6 (MM6) cells, the new diaryl ether 3'-demethyldihydromaldoxin (1) along with the known compound dihydromaldoxin (2), were isolated from fermentations of a Steganospora species. The structures of the compounds were elucidated by a combination of one- and two-dimensional NMR spectroscopy and mass spectrometry. Compounds (1) and (2) inhibited lipopolysaccharide (LPS)/interferon-γ (IFN-γ)-induced CXCL10 promoter activ…
Production of Norspermidine Contributes to Aminoglycoside Resistance in pmrAB Mutants of Pseudomonas aeruginosa
2019
Emergence of resistance to polymyxins in Pseudomonas aeruginosa is mainly due to mutations in two-components systems, that promote addition of 4-amino-4-deoxy-L-arabinose to the lipopolysaccharide (LPS) through upregulation of operon arnBCADTEF-ugd (arn) expression. Here, we demonstrate that mutations occurring in different domains of histidine kinase PmrB or in response regulator PmrA result in coresistance to aminoglycosides and colistin. All seventeen clinical strains tested exhibiting such a cross-resistance phenotype were found to be pmrAB mutants. As shown by gene deletion experiments, the decreased susceptibility of the mutants to aminoglycosides was independent from operon arn but r…
Same–different discrepancy in an exhaustive matching task
1988
In this study, we investigated in a multistimulus matching task the size of the discrepancy between response times for “same” and response times for “different” judgments. Frequently, results have shown that “same” judgments are faster than “different” judgments. Krueger (1984) found inversion in the speed advantage when stimuli were presented simultaneously and concluded that a self-termination factor would explain this result. In the experiment reported here, the subject had to exhaustively scan the whole set of items in the stimulus string. The analysis shows no significant interaction of presentation and response type; that is, the advantage for same stimuli is not reduced for simultane…
The German COPD cohort COSYCONET: Aims, methods and descriptive analysis of the study population at baseline
2016
Abstract Background The German COPD cohort study COSYCONET (" CO PD and SY stemic consequences- CO morbidities NET work") investigates the interaction of lung disease, comorbidities and systemic inflammation. Recruitment took place from 2010 to 2013 in 31 study centers. In addition to the baseline visit, follow-up visits are scheduled at 6, 18, 36 and 54 months after baseline. The study also comprises a biobank, image bank, and includes health economic data. Here we describe the study design of COSYCONET and present baseline data of our COPD cohort. Methods Inclusion criteria were broad in order to cover a wide range of patterns of the disease. In each visit, patients undergo a large panel …
Prenatal exposure to perfluoroalkyl substances, immune-related outcomes, and lung function in children from a Spanish birth cohort study.
2019
Background: Prenatal exposure to perfluoroalkyl substances (PFASs) has been associated with impaired immune and respiratory health during childhood but the evidence is inconsistent and limited for lung function. We studied the association between prenatal PFASs exposure and immune and respiratory health, including lung function, up to age 7 years in the Spanish INMA birth cohort study. Methods: We assessed four PFASs in maternal plasma samples collected during the 1st trimester of pregnancy (years: 2003-2008): perfluorohexane sulfonate (PFHxS), perfluorooctane sulfonate (PFOS), perfluorooctanoate (PFOA), and perfluorononanoate (PFNA). Mothers reported the occurrence (yes/no) of lower respir…
A model-based approach for assessing bronchodilator responsiveness in children: The conventional cutoff revisited
2020
An increase in FEV1 >=12% has been proposed in international guidelines as a clue to airway reversibility for diagnosing asthma in both adults and children. However, the validity of this cut-off has been questioned in the pediatric population. The aim of this study was to provide evidence that different cut-off values in BDR may be associated with better performance in discriminating among outpatient children with naïve asthma (A) and without asthma (NA). We compared three approaches: i) the conventional cutoff (12%); ii) the cut-off estimated by Youden's criteria; and iii) the cut-off based on a model-driven approach. we found that the conventional cut-off of 12% showed poor sensitivity in…
Wavelet Frames Generated by Spline Based p-Filter Banks
2014
This chapter presents a design scheme to generate tight and so-called semi-tight frames in the space of discrete-time periodic signals. The frames originate from oversampled perfect reconstruction periodic filter banks. The filter banks are derived from discrete-time and discrete periodic splines. Each filter bank comprises one linear phase low-pass filter (in most cases interpolating) and one high-pass filter, whose magnitude response mirrors that of a low-pass filter. In addition, these filter banks comprise a number of band-pass filters. In this chapter, frames generated by four-channel filter banks are briefly outlined (see Chap. 17 in [2] for details) and tight frames generated by six-…
Biorthogonal Wavelet Transforms Originating from Splines
2015
This chapter describes how to design families of biorthogonal wavelet transforms of signals and respective biorthogonal Wavelet bases in the signal space using spline-based prediction filters. Although the designed Wavelets originate from splines, they are not splines themselves. The design and implementation of the biorthogonal Wavelet transforms is done using the Lifting scheme. Most of the filters participating in the expansion of signals over the presented bases have infinite impulse responses and are implemented by recursive filtering whose computational cost is competitive with the FIR filtering cost. Properties of the designed Wavelets, such as symmetry, flat spectra, good time domai…
Quasi-interpolating and Smoothing Local Splines
2015
In this chapter, local quasi-interpolating and smoothing splines are described. Although approximation properties of local spline are similar to properties of the global interpolating and smoothing splines, their design does not require the IIR filtering of the whole data array. The computation of a local spline value at some point utilizes only a few adjacent grid samples. Therefore, local splines can be used for real-time processing of signals and for the design of FIR filter banks generating wavelets and wavelet frames (Chaps. 12 and 14). In the chapter, local splines of different orders are designed and their approximation properties are established which are compared with the propertie…
Selective killing of human monocytes and cytokine release provoked by sphingomyelinase (beta-toxin) of Staphylococcus aureus.
1996
The best-known activity of Staphylococcus aureus sphingomyelinase C, alias beta-toxin, is as a hemolysin that provokes hot-cold lysis of erythrocytes which contain substantial amounts of sphingomyelin in the plasma membrane. Sheep erythrocytes are most susceptible, and we found that one hemolytic unit, representing the toxin concentration that elicits 50% hemolysis of 2.5 X 10(8) erythrocytes per ml, corresponds to 0.05 enzyme units or to approximately 0.25 microg of sphingomyelinase per ml. The cytotoxic action of beta-toxin on nucleated cells has not been described in any detail before, and the present investigation was undertaken to fill this information gap. We now identify beta-toxin a…