Search results for "Response"
showing 10 items of 4136 documents
Asymmetric Disulfanylbenzamides as Irreversible and Selective Inhibitors of Staphylococcus aureus Sortase A
2020
Abstract Staphylococcus aureus is one of the most frequent causes of nosocomial and community‐acquired infections, with drug‐resistant strains being responsible for tens of thousands of deaths per year. S. aureus sortase A inhibitors are designed to interfere with virulence determinants. We have identified disulfanylbenzamides as a new class of potent inhibitors against sortase A that act by covalent modification of the active‐site cysteine. A broad series of derivatives were synthesized to derive structure‐activity relationships (SAR). In vitro and in silico methods allowed the experimentally observed binding affinities and selectivities to be rationalized. The most active compounds were f…
Non-Gaussian probability density function of SDOF linear structures under wind actions
1998
Abstract Wind velocity is usually analytically described adding a static mean term to a zero mean fluctuation stationary process. The corresponding aerodynamic alongwind force acting on a single degree of freedom (SDOF) structure can be considered as a sum of three terms proportional to the mean wind velocity, to the product between mean and fluctuating part of the wind velocity and to the square power of the fluctuating wind velocity, respectively. The latter term, often neglected in the literature, is responsible for the non-Gaussian behaviour of the response. In this paper a method for the evaluation of the stationary probability density function of SDOF structures subjected to non-Gauss…
An association model for bivariate data with application to the anlysis of university students' success.
2015
The academic success of students is a priority for all universities. We analyze the students' success at university by considering their performance in terms of both ‘qualitative performance’, measured by their mean grade, and ‘quantitative performance’, measured by university credits accumulated. These data come from an Italian University and concern a cohort of students enrolled at the Faculty of Economics. To jointly model both the marginal relationships and the association structure with covariates, we fit a bivariate ordered logistic model by penalized maximum likelihood estimation. The penalty term we use allows us to smooth the association structure and enlarge the range of possible …
The Psychological Science Accelerator’s COVID-19 rapid-response dataset
2023
Funder: Amazon Web Services (AWS) Imagine Grant
Estimating person parameters via item response model and simple sum score in small samples with few polytomous items: A simulation study
2018
Background The Item Response Theory (IRT) is becoming increasingly popular for item analysis. Theoretical considerations and simulation studies suggest that parameter estimates will become precise only by utilizing many items in large samples. Method A simulation study focusing on a single scale was performed on data with (a) n = 40, 60, 80, 120, 200, 300, 500, and 900 cases utilizing (b) 4, 8, 16, or 32 items. The items were (c) symmetrically distributed vs. skew (skewness 0, 1, and 2). Item loadings were (d) homogeneous vs. heterogeneous. Item loadings were (e) low vs. high. Half of the items had (f) a correlated error or not. The number of answering categories (g) was four vs. five. A to…
Fast and universal estimation of latent variable models using extended variational approximations
2022
AbstractGeneralized linear latent variable models (GLLVMs) are a class of methods for analyzing multi-response data which has gained considerable popularity in recent years, e.g., in the analysis of multivariate abundance data in ecology. One of the main features of GLLVMs is their capacity to handle a variety of responses types, such as (overdispersed) counts, binomial and (semi-)continuous responses, and proportions data. On the other hand, the inclusion of unobserved latent variables poses a major computational challenge, as the resulting marginal likelihood function involves an intractable integral for non-normally distributed responses. This has spurred research into a number of approx…
Ranking Scientific Journals Via Latent Class Models for Polytomous Item Response Data
2015
Summary We propose a model-based strategy for ranking scientific journals starting from a set of observed bibliometric indicators that represent imperfect measures of the unobserved ‘value’ of a journal. After discretizing the available indicators, we estimate an extended latent class model for polytomous item response data and use the estimated model to cluster journals. We illustrate our approach by using the data from the Italian research evaluation exercise that was carried out for the period 2004–2010, focusing on the set of journals that are considered relevant for the subarea statistics and financial mathematics. Using four bibliometric indicators (IF, IF5, AIS and the h-index), some…
A heuristic method for estimating attribute importance by measuring choice time in a ranking task
2012
The evaluation of a product or service in terms of its attributes has been broadly studied in marketing, management and decision sciences. However, methods for finding important attributes have theoretical and practical limitations. The former are related to the selection of the most appropriate model; the latter are due to large number of variables that affect the specific experimental context. This study aims to present a new methodology that captures attribute preferences from a respondent and in particular, by using the choice time in a ranking task, it allows to indirectly obtain the importance weights for several tested attributes through a simple, fast and inexpensive procedure. More…
Generalized Symmetry Models for Hypercubic Concordance Tables
2000
Summary Frequency data obtained classifying a sample of 'units' by the same categorical variable repeatedly over 'components', can be arranged in a hypercubic concordance table (h.c.t.). This kind of data naturally arises in a number of different areas such as longitudinal studies, studies using matched and clustered data, item-response analysis, agreement analysis. In spite of the substantial diversity of the mechanisms that can generate them, data arranged in a h.c.t. can all be analyzed via models of symmetry and quasi-symmetry, which exploit the special structure of the h.c.t. The paper extends the definition of such models to any dimension, introducing the class of generalized symmetry…
Power and Type I Error of the Mean and Covariance Structure Analysis Model for Detecting Differential Item Functioning in Graded Response Items.
2016
In this simulation study, we investigate the power and Type I error rate of a procedure based on the mean and covariance structure analysis (MACS) model in detecting differential item functioning (DIF) of graded response items with five response categories. The following factors were manipulated: type of DIF (uniform and non-uniform), DIF magnitude (low, medium and large), equality/inequality of latent trait distributions, sample size (100, 200, 400, and 800) and equality or inequality of the sample sizes across groups. The simulated test was made up of 10 items, of which only 1 contained DIF. One hundred replications were generated for each simulated condition. Results indicate that the MA…