Search results for "Restenosis"

showing 10 items of 73 documents

Cryoplasty versus angioplasty in the treatment of arterial restenosis in an experimental model of atherosclerosis in rabbits

2014

Abstract Cryoplasty may reduce the incidence of post-angioplasty restenosis in peripheral atherosclerotic arteries. Our study is looking to investigate the mid-term effects (4 weeks) of an FDA-approved cryoplasty catheter (PolarCath®, Boston Scientific) compared to a conventional angioplasty catheter using a hypercholesterolemic rabbit model of arterial restenosis based on diet plus vessel injury. Thirty-six normolipidemic, 3-month old male New Zealand White rabbits were used. Balloon angioplasty was performed on left external iliac arteries on day 1. Animals were fed with a hypercholesterolemic diet for 60 days. On day 120, three groups of animals were established: conventional PTA (percut…

Malemedicine.medical_specialtyPercutaneousmedicine.medical_treatmentHypercholesterolemiaCryotherapyConstriction PathologicBalloonCryosurgeryIliac ArteryGeneral Biochemistry Genetics and Molecular BiologyRestenosisInternal medicineAngioplastyAnimalsMedicinebusiness.industryGeneral MedicineModels TheoreticalAtherosclerosismedicine.diseaseStenosisCatheterCryotherapyCardiologyRabbitsTunica IntimaGeneral Agricultural and Biological SciencesbusinessVascular StenosisAngioplasty BalloonCryobiology
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Subclavian Stenosis/Occlusion in Patients with Subclavian Steal and Previous Bypass of Internal Mammary Interventricular Anterior Artery: Medical or …

2004

There are only a few published studies on the association between subclavian steal syndrome and ischemic heart disease. The objective of this report is to evaluate the efficacy of subclavian stenoocclusion treatment in patients with subclavian steal syndrome (SSS) and previous cor- onary bypass. Over the last 8 years we observed 207 patients who underwent left internal mammary artery–intraventricular artery (LIMA–IVA) bypass graft. Of these, 31 patients were affected by steno-occlusion of the homolateral subclavian artery. Ten patients (group 1) showed latent vertebral-SSS and were pharmacologically treated. Seven patients (group 2) had an intermittent vertebral-SSS; four patients were trea…

Malemedicine.medical_specialtyTiclopidinemedicine.medical_treatmentConstriction PathologicSubclavean stenosis/occlusionAnginaSubclavian Steal SyndromeRestenosisRisk FactorsInternal medicinemedicine.arteryAngioplastymedicineHumanscardiovascular diseasesInternal Mammary-Coronary Artery AnastomosisSubclavian arteryAgedAspirinmedicine.diagnostic_testbusiness.industryAngioplastyStentGeneral MedicineMiddle Agedmedicine.diseaseSurgerybody regionssurgical procedures operativeAngiographycardiovascular systemCardiologyPlatelet aggregation inhibitorFemaleStentsSurgeryCardiology and Cardiovascular MedicinebusinessSubclavian steal syndromePlatelet Aggregation InhibitorsAnnals of Vascular Surgery
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Combining Sirolimus-eluting Stents and External Irradiation in Cholesterol-fed Rabbits Increased Incomplete Stent Apposition and Decreased Re-endothe…

2009

Restenosis after the implantation of a drug-eluting stent or after vascular irradiation therapy shares similar physiopathological mechanisms. No experimental data are currently available on vascular wall behavior after external irradiation on arteries stented with sirolimus-eluting stents (SES). Ten New Zealand white rabbits received a 0.5% cholesterol-enriched chow for 1 month. Bilateral iliac artery stent implantation was then performed with an SES (Cypher; Cordis Corp). The animals were randomized into either an irradiated group (I, 2 Gy external x-ray irradiation, n = 5) or a control group (C, n = 5). The cholesterol-enriched chow was continued for 1 additional month after stent implant…

Malemedicine.medical_specialtyTime FactorsEndotheliummedicine.medical_treatmentUrologyCholesterol Dietarychemistry.chemical_compoundRestenosismedicineAnimalsSirolimusPharmacologyCholesterolbusiness.industryX-RaysStentDose-Response Relationship RadiationDrug-Eluting StentsIncomplete stent appositionequipment and suppliesmedicine.diseaseImmunohistochemistryPathophysiologySurgeryStenosisCholesterolmedicine.anatomical_structurechemistrySirolimusEndothelium VascularRabbitsTunica IntimaTunica MediaCardiology and Cardiovascular MedicinebusinessImmunosuppressive Agentsmedicine.drugJournal of Cardiovascular Pharmacology
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9-Month Clinical and Angiographic Outcomes of the COBRA Polyzene-F NanoCoated Coronary Stent System

2016

Abstract Objectives The aim of this study was to assess the safety and effectiveness of the COBRA Polyzene-F NanoCoated Coronary Stent System (CeloNova Biosciences, San Antonio, Texas) for the treatment of de novo coronary artery lesions. Background Polyzene-F–coated coronary stents have shown reduced thrombogenicity and inflammation in preclinical studies. Methods Patients with de novo coronary artery lesions meeting eligibility criteria were enrolled in a nonrandomized, prospective clinical trial. The primary endpoint was target vessel failure (TVF) (defined as a composite of cardiac death, myocardial infarction, or clinically driven target vessel revascularization) at 9 months. A pre-spe…

Malemedicine.medical_specialtyTime FactorsPolymersmedicine.medical_treatmentCoronary Artery Disease030204 cardiovascular system & hematologyCoronary AngiographyProsthesis DesignCoronary RestenosisCoronary artery disease03 medical and health sciencesOrganophosphorus Compounds0302 clinical medicineCoated Materials BiocompatibleCoronary thrombosisRestenosisPredictive Value of TestsRisk FactorsInternal medicineAngioplastyCoronary stentmedicineClinical endpointHumansProspective Studies030212 general & internal medicineMyocardial infarctionAngioplasty Balloon CoronaryAgedbusiness.industryCoronary ThrombosisStentMiddle Agedmedicine.diseaseCoronary VesselsSurgeryTreatment OutcomeCardiologyNanoparticlesFemaleStentsCardiology and Cardiovascular MedicinebusinessJACC: Cardiovascular Interventions
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Optical Coherence Tomography Versus Intravascular Ultrasound to Evaluate Coronary Artery Disease and Percutaneous Coronary Intervention

2013

ObjectivesWe compared intravascular ultrasound (IVUS) and 2 different generations of optical coherence tomography (OCT)—time-domain OCT (TD-OCT) and frequency-domain OCT (FD-OCT)—for the assessment of coronary disease and percutaneous coronary intervention (PCI) using stents.BackgroundOCT is a promising light-based intravascular imaging modality with higher resolution than IVUS. However, the paucity of data on OCT image quantification has limited its application in clinical practice.MethodsA total of 227 matched OCT and IVUS pull backs were studied. One hundred FD-OCT and IVUS pull backs in nonstented (n = 56) and stented (n = 44) vessels were compared. Additionally, 127 matched TD-OCT and …

Malemedicine.medical_specialtyTime Factorsgenetic structuresmedicine.medical_treatmentTreatment outcomeSeverity of Illness Indexintravascular ultrasoundCoronary RestenosisCoronary artery diseaseOptical coherence tomographyPredictive Value of TestsNeointimaIntravascular ultrasoundmedicineHumanscardiovascular diseasesUltrasonography InterventionalAgedCell ProliferationAnalysis of VarianceHyperplasiaoptical coherence tomographymedicine.diagnostic_testbusiness.industrypercutaneous coronary interventionCoronary StenosisPercutaneous coronary interventionMiddle Agedequipment and suppliesmedicine.diseaseCoronary Vesselseye diseasesTreatment Outcomesurgical procedures operativeLinear ModelsFemaleStentssense organsTomographyRadiologyUltrasonographybusinessCardiology and Cardiovascular MedicineTomography Optical CoherenceJACC: Cardiovascular Interventions
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Real world safety and efficacy of the Janus Tacrolimus-Eluting stent: long-term clinical outcome and angiographic findings from the Tacrolimus-Elutin…

2009

Objectives: We sought to evaluate the safety and performance of the Janus Tacrolimus-Eluting stent (TES) in an unselected population of patients, without application of restrictive clinical or angiographic criteria. Background: Continued attention to the safety, efficacy, and deliverability of first-generation drug eluting stents has led to the development of new antiproliferative agents with alternative stent platforms and different drug carrier vehicles. Methods: The TEST (Tacrolimus Eluting STent) registry is a prospective, nonrandomized single-center registry in which 140 consecutive patients who underwent single- or multi-vessel percutaneous coronary intervention between February 2005 …

Malemedicine.medical_specialtyTime Factorsmedicine.medical_treatmentPopulationMyocardial InfarctionRestenosiKaplan-Meier EstimateCoronary AngiographyProsthesis DesignRisk AssessmentTacrolimusCoronary RestenosisRestenosismedicineHumansRadiology Nuclear Medicine and imagingMyocardial infarctionProspective StudiesRegistriesAngioplasty Balloon CoronaryeducationAgededucation.field_of_studybusiness.industryCoronary StenosisStentPercutaneous coronary interventionTacrolimus eluting stent.Cardiovascular AgentsDrug-Eluting StentsGeneral MedicineMiddle Agedmedicine.diseaseTacrolimusSurgeryTreatment OutcomeAntiproliferative AgentsFemaleRadiologySafetyCardiology and Cardiovascular MedicinebusinessMaceCatheterization and cardiovascular interventions : official journal of the Society for Cardiac AngiographyInterventions
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Feasibility of Implanting 50-60 mm-Tapered Drug Eluting Stents in Chronic Total Occlusions.

2018

Abstract Background Percutaneous coronary intervention (PCI) of chronic total occlusions (CTO) usually involves multiple overlapping stents implantation to cover long coronary segments. A higher rate of restenosis has been described with stent overlapping. Recently, new long tapered stents emerged as a potential tool for treating long coronary lesions. Feasibility of using these new devices for the CTO PCI has not been described. The aim of this work was to describe our initial experience with 50 and 60 mm-long tapered sirolimus-eluting stents (SES) in CTO PCI. Methods We included 54 consecutive patients who underwent a CTO PCI and in whom an attempt to implant a 50 or 60 mm-long tapered SE…

Malemedicine.medical_specialtyTime Factorsmedicine.medical_treatmentTarget vessel030204 cardiovascular system & hematologyProsthesis DesignCoronary Restenosis03 medical and health sciences0302 clinical medicinePercutaneous Coronary InterventionRestenosismedicineHumanscardiovascular diseases030212 general & internal medicineVascular PatencyAgedRetrospective StudiesSirolimusbusiness.industryPercutaneous coronary interventionStentCardiovascular AgentsDrug-Eluting StentsGeneral MedicineMiddle Agedmedicine.diseaseSurgerysurgical procedures operativeTreatment OutcomeCoronary OcclusionConventional PCIChronic DiseaseFeasibility StudiesFemaleImplantCardiology and Cardiovascular MedicinebusinessCardiovascular revascularization medicine : including molecular interventions
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Bioresorbable vascular scaffold versus everolimus-eluting stents or drug eluting balloon for the treatment of coronary in-stent restenosis: 1-Year fo…

2017

Objectives to compare the 1-year outcome between bioresorbable vascular scaffold (BVS), everolimus-eluting stent (EES), and drug-eluting balloon (DEB) for in-stent restenosis (ISR) treatment. Background BVS has been proposed as alternative for ISR treatment. To date a direct comparison between BVS and DES or DEB for ISR treatment is lacking. Methods We retrospectively analyzed all ISR lesions treated with BVS, DEB, and EES from January 2012 to December 2014. A total of 548 lesions (498 patients) were included. By applying two propensity-score matching, 93 lesions treated with BVS were compared with 93 lesions treated with DEB, and 100 lesions treated with BVS were compared to 100 lesions tr…

Malemedicine.medical_specialtyTime Factorsmedicine.medical_treatmentUrology030204 cardiovascular system & hematologyProsthesis DesignBalloonRisk AssessmentCardiac CathetersCoronary Restenosis03 medical and health sciences0302 clinical medicineCoated Materials BiocompatibleRestenosisRisk FactorsAbsorbable ImplantsmedicineHumansRadiology Nuclear Medicine and imagingEverolimus030212 general & internal medicineAngioplasty Balloon CoronaryPropensity ScoreAgedRetrospective StudiesBioresorbable vascular scaffoldin stent restenosibusiness.industryIncidence (epidemiology)percutaneous coronary interventionStentPercutaneous coronary interventionCardiovascular AgentsDrug-Eluting StentsGeneral MedicineMiddle Agedmedicine.diseaseTreatment OutcomeItalyDrug-eluting stentPropensity score matchingFemalebioresorbable vascular scaffolddrug eluting balloonCardiology and Cardiovascular Medicinebusinessdrug eluting stent
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Fludarabine prevents smooth muscle proliferation in vitro and neointimal hyperplasia in vivo through specific inhibition of STAT-1 activation.

2007

Drug-eluting stents are increasingly used to reduce in-stent restenosis and adverse cardiac events after percutaneous coronary interventions. However, the race for the ideal drug-eluting stent is still on, with special regard to the best stent-coating system and the most effective and less toxic drug. Fludarabine, a nucleoside analog, has both anti-inflammatory and antiproliferative cellular effects. The aim of the present study was to assess the cellular and molecular effects of fludarabine on vascular smooth muscle cell (VSMC) growth in vitro and in vivo and the feasibility and efficacy of a fludarabine-eluting stent. To study the biomolecular effects of fludarabine on VSMC proliferation…

Malemedicine.medical_specialtyVascular smooth muscleTime FactorsPhysiologyMyocytes Smooth MusclePharmacologyProsthesis DesignTransfectionMuscle Smooth VascularRestenosisIn vivoPhysiology (medical)medicineAnimalsCarotid StenosisRNA AntisensePhosphorylationRats WistarAortaCells CulturedCell ProliferationNeointimal hyperplasiaHyperplasiaDose-Response Relationship Drugbusiness.industryCardiovascular AgentsHyperplasiaJanus Kinase 2medicine.diseaseFludarabineSurgeryRatsDisease Models AnimalSTAT1 Transcription FactorCardiovascular agentSTAT proteinFeasibility StudiesStentsRabbitsCardiology and Cardiovascular MedicinebusinessCarotid Artery InjuriesTunica IntimaAngioplasty BalloonVidarabinemedicine.drug
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Peripheral atherosclerosis is associated with the occurrence of restenosis after percutaneous coronary intervention

2007

The aim of our study was to evaluate, in patients with proven coronary artery disease (CAD) and treated with elective percutaneous coronary intervention (PCI), whether the coexistence of asymptomatic carotid and femoral atherosclerotic lesions would provide prognostic information in terms of occurrence of restenosis.We studied 104 patients with CAD (M/F=77/27), mean age 60.5+/-9 years. All patients were treated with elective PCI. After PCI the suspicion of restenosis was confirmed by coronary angiography. All patients underwent ultrasound duplex scan of carotid and femoral-popliteal-tibial axis to detect atherosclerotic lesions. According to ultrasound results, patients were classified as n…

Malemedicine.medical_specialtymedicine.medical_treatmentBalloonAsymptomaticPeripheral atherosclerosispercutaneous coronary interventionCoronary RestenosisCoronary artery diseaseRestenosisInternal medicineAngioplastymedicineHumanscardiovascular diseasesAngioplasty Balloon CoronaryAgedPeripheral Vascular Diseasesbusiness.industryPercutaneous coronary interventionGeneral MedicineMiddle AgedAtherosclerosisPrognosismedicine.diseasePeripheralConventional PCICardiologyFemalemedicine.symptomCardiology and Cardiovascular MedicinebusinessCoronary Artery Disease
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