Search results for "Retard"

showing 10 items of 146 documents

Excess of de novo variants in genes involved in chromatin remodelling in patients with marfanoid habitus and intellectual disability.

2020

PurposeMarfanoid habitus (MH) combined with intellectual disability (ID) (MHID) is a clinically and genetically heterogeneous presentation. The combination of array CGH and targeted sequencing of genes responsible for Marfan or Lujan–Fryns syndrome explain no more than 20% of subjects.MethodsTo further decipher the genetic basis of MHID, we performed exome sequencing on a combination of trio-based (33 subjects) or single probands (31 subjects), of which 61 were sporadic.ResultsWe identified eight genes with de novo variants (DNVs) in at least two unrelated individuals (ARID1B, ATP1A1, DLG4, EHMT1, NFIX, NSD1, NUP205 and ZEB2). Using simulation models, we showed that five genes (DLG4, NFIX, …

ProbandMale[SDV]Life Sciences [q-bio]intellectual deficiencyMESH: NFI Transcription Factorschromatin remodelingMarfan SyndromeCraniofacial AbnormalitiesMESH: ChildIntellectual disabilityMESH: Craniofacial AbnormalitiesMESH: Mental Retardation X-LinkedExomeChildde novo variantsGenetics (clinical)Exome sequencingGeneticsMESH: ExomeMESH: Middle AgedbiologyMESH: Genetic Predisposition to DiseaseMiddle AgedNFIXMESH: Young AdultFemaleAdultMESH: MutationAdolescentChromatin remodelingMESH: Intellectual DisabilityMESH: Marfan SyndromeEHMT1Young AdultMESH: Whole Exome SequencingIntellectual DisabilityExome SequencingGeneticsmedicineHumansGenetic Predisposition to Diseasemarfanoid habitusGeneMESH: Neurodevelopmental DisordersMESH: AdolescentMESH: HumansGenetic heterogeneityMESH: Chromatin Assembly and DisassemblyMESH: Histone-Lysine N-MethyltransferaseMESH: AdultHistone-Lysine N-Methyltransferasemedicine.diseaseChromatin Assembly and DisassemblyMESH: MaleNFI Transcription FactorsNeurodevelopmental DisordersMutationbiology.proteinMental Retardation X-LinkedMESH: FemaleJournal of medical genetics
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Modelling and optimization of modular system for power generation from a salinity gradient

2019

Abstract Pressure retarded osmosis has been proposed for power generation from a salinity gradient resource. The process has been promoted as a promising technology for power generation from renewable resources, but most of the experimental work has been done on a laboratory size units. To date, pressure retarded osmosis optimization and operation is based on parametric studies performed on laboratory scale units, which leaves a gap in our understanding of the process behaviour in a full-scale modular system. A computer model has been developed to predict the process performance. Process modelling was performed on a full-scale membrane module and impact of key operating parameters such as h…

Process modeling060102 archaeologyRenewable Energy Sustainability and the Environmentbusiness.industry020209 energyPressure-retarded osmosisProcess (computing)06 humanities and the arts02 engineering and technologyOsmosisRenewable energyMembrane technologyElectricity generation0202 electrical engineering electronic engineering information engineeringEnvironmental science0601 history and archaeologyProcess optimizationbusinessProcess engineeringRenewable Energy
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On a step method and a propagation of discontinuity

2019

In this paper we analyze how to compute discontinuous solutions for functional differential equations, looking at an approach which allows to study simultaneously continuous and discontinuous solutions. We focus our attention on the integral representation of solutions and we justify the applicability of such an approach. In particular, we improve the step method in such a way to solve a problem of vanishing discontinuity points. Our solutions are considered as regulated functions.

Regulated functionIntegral representationregulated function discontinuous function retarded differential equation delay Kurzweil-Stieltjes integral breaking pointsDifferential equationComputer scienceApplied Mathematics010102 general mathematicsMathematicsofComputing_NUMERICALANALYSIS01 natural sciences010101 applied mathematicsComputational MathematicsDiscontinuity (linguistics)Settore MAT/05 - Analisi MatematicaApplied mathematics0101 mathematicsFocus (optics)Step methodComputational and Applied Mathematics
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New reactive isoeugenol based phosphate flame retardant : toward green epoxy resins

2019

A biobased reactive phosphate flame retardant derived from isoeugenol was synthesized and fully characterized (1H, 13C, 31P NMR, FTIR, MS) with the aim of improving flame retardancy behavior of bio...

Renewable Energy Sustainability and the EnvironmentGeneral Chemical Engineering02 engineering and technologyGeneral ChemistryEpoxy[PHYS.MECA]Physics [physics]/Mechanics [physics]010402 general chemistry021001 nanoscience & nanotechnologyPhosphate01 natural scienceshumanities0104 chemical scienceschemistry.chemical_compoundIsoeugenolfluids and secretionschemistryvisual_artvisual_art.visual_art_mediumEnvironmental ChemistryOrganic chemistryFourier transform infrared spectroscopy0210 nano-technologyreproductive and urinary physiologyComputingMilieux_MISCELLANEOUSFire retardant
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Pressure Retarded Osmosis: a Membrane Process for Environmental Sustainability

2016

Salinity Gradient Power (SGP) based on the controlled mixing between two solutions at different salinities is a viable alternative to produce power from renewable sources. Pressure Retarded Osmosis (PRO) is one of the most promising technologies proposed so far for the exploitation of such energy source. Apart from the typical source of salinity gradients, namely river water and seawater, more and more interest has been raised recently towards the use of non-conventional saline solutions. In this work, water originating from a sewage treatment plant is used as the dilute solution (feed solution), while brine exiting from a desalination plant is used as the concentrate (draw solution), thus …

Salinity gradient power Pressure Retarded Osmosis Process Modelling Brine MembraneSettore ING-IND/26 - Teoria Dello Sviluppo Dei Processi ChimiciSettore ING-IND/24 - Principi Di Ingegneria Chimicalcsh:Computer engineering. Computer hardwareSettore ING-IND/25 - Impianti Chimicilcsh:TP155-156lcsh:TK7885-7895lcsh:Chemical engineeringChemical Engineering Transactions
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Optical retarder system with programmable spectral retardance.

2014

An optical system that works as a retarder waveplate with programmable spectral retardance is proposed. The system is based on a pixelated liquid crystal on silicon (LCoS) spatial light modulator (SLM). The input light beam is spectrally dispersed and different spectral components are projected onto different pixels of the LCoS-SLM. A different retardance is then addressed for each pixel, adapted to the incoming wavelength. Light reflected from the SLM is then recombined by the same setup. In this way a programmable polarization spectrum can be encoded. We illustrate the broadband characterization that is required for proper use of the system. Then several examples are shown, including spec…

SiliconSpatial light modulatorMaterials sciencebusiness.industrySpectrum AnalysisPhysics::OpticsOptical DevicesPhysics::Classical PhysicsRetarderWaveplateAtomic and Molecular Physics and Opticslaw.inventionLiquid CrystalsLiquid crystal on siliconWavelengthLight intensityOpticslawLight beambusinessBeam splitterOptics letters
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Determination of organophosphate flame retardants in soil and fish using ultrasound-assisted extraction, solid-phase clean-up, and liquid chromatogra…

2017

A solid–liquid extraction method in combination with high‐performance liquid chromatography and tandem mass spectrometry was developed and optimized for extraction and analysis of organophosphorus flame retardants in soil and fish. Methanol was chosen as the optimum extraction solvent, not only in terms of extraction efficiency, but also for its broader analyte coverage. The subsequent clean‐up by solid‐phase extraction is required to eliminate matrix coextractives and reduce matrix effects. Recoveries of the optimized method were 50–121% for soil and 47–123% for biota, both with high precision (RSDs <12% in soil and <23% in biota). The method limits of detection ranged from 0.06 to 0.20 ng…

Solid–liquid extractionFood ContaminationFiltration and SeparationLiquid chromatography with tandem mass spectrometry010501 environmental sciencesMass spectrometry01 natural sciencesHigh-performance liquid chromatographyAnalytical ChemistryMatrix (chemical analysis)SoilTandem Mass SpectrometryAnimalsSoil PollutantsSolid phase extractionChromatography High Pressure LiquidFlame Retardants0105 earth and related environmental sciencesDetection limitChromatographyChemistrySolid Phase Extraction010401 analytical chemistryExtraction (chemistry)FishesSoil classificationSoil contaminationOrganophosphates0104 chemical sciencesFishSeafoodOrganophosphorus flame retardantsJournal of Separation Science
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Enhancing extraction performance of organophosphorus flame retardants in water samples using titanium hierarchical porous silica materials as sorbent…

2021

Abstract A sorbent for the extraction of organophosphorus flame retardants has been proposed, based on UVM-7 (University of Valencia Materials) mesoporous silica doped with titanium. Designed cartridges have been applied to the extraction and preconcentration of flame retardants in water samples, followed by gas chromatography coupled to a mass spectrometry detector. Firstly, UVM-7 materials with different contents of titanium were synthesized and characterized by several techniques, thus confirming the proper mesoporous architecture. The potential of these materials was assessed in comparison with their morphological properties, resulting Ti50-UVM-7 the best solid phase. Several extraction…

Sorbent010402 general chemistry01 natural sciencesBiochemistryAnalytical Chemistrychemistry.chemical_compoundOrganophosphorus CompoundsLimit of DetectionSolid phase extractionSolid Phase MicroextractionFlame RetardantsDetection limitTitaniumChromatographyChemistry010401 analytical chemistryOrganic ChemistryExtraction (chemistry)WaterGeneral MedicineMesoporous silicaSilicon DioxideOrganophosphates0104 chemical sciencesGas chromatographyAdsorptionMesoporous materialPorosityTriphenyl phosphateJournal of chromatography. A
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New perspectives on diastereoselective determination of hexabromocyclododecane traces in fish by ultra high performance liquid chromatography-high re…

2014

a b s t r a c t A new analytical method is presented for diastereoisomer-specific identification and quantitation of hexabromocyclododecanes (HBCD) in fish samples. The method is based on extraction of the target analytes from samples with a mixture of organic solvents, with further three-stage clean-up includ- ing destructive removal of matrix components with sulphuric acid and acid-impregnated silica gel, and Florisil adsorption column chromatography. Ultra high performance liquid chromatography (UPLC) cou- pled with high resolution (HR) Orbitrap mass spectrometry featuring heated electrospray ionization (HESI-II) interface operated in negative ion mode was employed for the identification…

Spectrometry Mass Electrospray IonizationSalmo salarAnalytical chemistrySilica GelMass spectrometryOrbitrapBiochemistryHigh-performance liquid chromatographyAnalytical Chemistrylaw.inventionMatrix (chemical analysis)chemistry.chemical_compoundColumn chromatographylawAnimalsChromatography High Pressure LiquidFlame RetardantsDetection limitHexabromocyclododecaneChromatographyChemistryOrganic ChemistryStereoisomerismGeneral MedicineRepeatabilityHydrocarbons BrominatedCalibrationWater Pollutants ChemicalJournal of chromatography. A
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Bromēto liesmas slāpētāju noteikšana medību gaļas paraugos ar augstas izšķirtspējas masspektrometrijas metodēm

2017

Bromēto liesmas slāpētāju noteikšanas medību gaļas paraugos ar augstas izšķirtspējas masspektrometrijas metodēm. Bāliņš Rolands, zinātniskais vadītājs: Dr. ķīm., Dzintars Začs, konsultante: Ķīm. maģ., doktorante Jekaterina Rjabova. Maģistra darbs, 47 lappuses, 9 attēli, 21 tabula, 30 literatūras avoti, 2 pielikumi. Latviešu valodā. Maģistra darbā ir apkopota literatūra par analizētajiem savienojumiem, to pielietošanu, toksiskumu, izplatību dabā un to analīžu metodēm. Iegūtie rezultāti ir apkopoti tabulu un diagrammu veidā. Darbā tika veikta bromēto liesmas slāpētāju tetrabrom bisfenola A (TBBPA), heksabromciklododekāna (HBCDD) un polibromēto difenil ēteru (PBDEs) noteikšana medījumu gaļas p…

TBBPAMASS SPECTROMETRYHBCDDPBDEsBROMINATED FLAME RETARDANTSĶīmija
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