Search results for "Retina"
showing 10 items of 864 documents
Caractérisation et prévention des conséquences d’un syndrome métabolique dans la rétine
2018
Metabolic syndrome (MetS) results from carbohydrate and lipid disorders that originate from misbalanced energy metabolism. MetS is a risk factor for type 2 diabetes that, in pathophysiological conditions, is characterized by vascular alterations, particularly in the retina, creating the diabetic retinopathy (DR). Despite it presents a barrier limiting the input of blood factors, the retina is under metabolic variations. The consequences of MetS in the retina have not been characterized. MetS would be responsible for the inflammation and microvascular alterations in the retina and could participate to the development of age-related macular degeneration (AMD). A diet rich in omega-3 long chai…
RPE/Choroid and Neuroretina Differences in Lipid Profile in Humans, and Possible Correlations to Dietary Lipid Intake
2008
International audience; Purpose: : To provide data on the differences in the lipid profile of the neural retina and RPE/choroid in healthy human eyes, and to establish plausible relationships with dietary fat intake, by comparing the lipid profile of the extra orbital fat. Methods: : Human eyes were collected from 28 human donors. The neural retina was dissected from the RPE/choroid. In 6 donors, the lacrimal gland and a piece of the extra orbital fat were collected. The lipid profile of the human samples was analyzed into classes. Phospholipids and cholesteryl esters were purified from RPE/choroid. The fatty acid composition of the retina, lipid fractions of RPE/choroid, and lacrimal gland…
Retinal Straylight Before and After Penetrating Keratoplasty in an Eye with a Post-Herpetic Corneal Scar
2008
Objetivo: Estudio in vivo de la luz dispersa que alcanza la retina en un paciente antes y despues de someterse a una queratoplastia penetrante (o sus siglas en ingles, PKP). Metodos: En un paciente varon de 65 anos con una ulcera corneal herpetica se midio la proporcion de luz dispersa que alcanza la retina tanto antes como despues de una PKP, utilizando para ello un metodo psicometrico denominado "de comparacion por compensacion" («Compensation comparison method», C-Quant straylightmeter, Oculus GmbH, Alemania). Resultados: La cantidad de luz dispersa que alcanza la retina medida antes de la cirugia fue elevada en comparacion con los valores obtenidos en estudios previos en sujetos normale…
Retinal Detachments Following Successful Idiopathic Macular Holes Surgery
2009
Purpose: : To evaluate long term outcome of successfully operated idiopathic macular holes (IMH).Methods: : We conducted a comparative retrospective case series in two academic centers. IMH were operated with pars plana vitrectomy, intravitreal gas and internal limiting membrane peeling between 2002 and 2005. All these macular holes were analyzed with Stratus OCT before and after the surgery. We divided them into 4 groups: group 1: vitrectomy in pseudophakic eyes; group 2: vitrectomy and cataract extraction as a combined procedure; group 3: vitrectomy followed by cataract extraction; group 4: vitrectomy in pseudophakic eyes. We noted the anatomical and functional results and we studied seri…
Decreased Perifoveal Sensitivity Detected by Microperimetry in Patients Using Hydroxychloroquine and without Visual Field and Fundoscopic Anomalies
2015
Purpose. To evaluate the usefulness of microperimetry in the early detection of the ocular anomalies associated with the use of hydroxychloroquine.Methods. Prospective comparative case series study comprising 14 healthy eyes of 7 patients (group A) and 14 eyes of 7 patients under treatment with hydroxychloroquine for the treatment of rheumatologic diseases and without fundoscopic or perimetric anomalies (group B). A comprehensive ophthalmological examination including microperimetry (MP) and spectral-domain optical coherence tomography was performed in both groups.Results. No significant differences were found in mean MP foveal sensitivity between groupsP=0.18. However, mean MP overall sens…
Pilot Study on Visual Function and Fundus Autofluorescence Assessment in Diabetic Patients.
2015
Purpose. Evaluate optimized fundus autofluorescence (FAF) imaging in early stages of diabetic retinopathy (DR) and relate findings with conventional colour fundus imaging and visual function in diabetic patients and control subjects.Materials and Methods. FAF and colour images were obtained using the CR-2 Plus digital nonmydriatic retinal camera in seven diabetic patients and thirteen control subjects. Visual-Functioning Questionnaire-25 (VFQ-25) and Diabetes Self-Management Questionnaire (DSMQ) were used to assess the quality of life and diabetes self-care. Contrast sensitivity function (CSF) was evaluated with the Vistech 6500 chart.Results. FAF and optimized-FAF imaging showed more retin…
Intravitreal anti-vascular endothelial growth factors, panretinal photocoagulation and combined treatment for proliferative diabetic retinopathy: a s…
2020
Purpose: to conduct a systematic review with network meta‐analysis (NMA) of randomized clinical trials (RCTs) comparing panretinal photocoagulation (PRP) versus anti‐vascular endothelial growth factor (VEGF) treatment alone or in combination with PRP, for proliferative diabetic retinopathy (PDR).Methods: PubMed, Medline and Embase databases were searched for RCTs comparing PRP versus intravitreal anti‐VEGF therapy and/or combined PRP and intravitreal anti‐VEGF for PDR. The primary outcome measures were the mean best corrected visual acuity (BCVA) change and the regression of neovascularization. Mean change of central macular thickness (CMT), the subgroup analyses of patients without diabeti…
Activities of angiotensin-converting enzymes ACE1 and ACE2 and inhibition by bioactive peptides in porcine ocular tissues.
2009
An active local renin-angiotensin system (RAS) has recently been found in the human eye. The aim of the present study was to compare the activities of central RAS enzymes (ACE1 and 2) in porcine ocular tissues, morphologically and physiologically close to the human eye. In addition, the effects of three ACE-inhibitory tripeptides on these enzymes were evaluated.Enucleated fresh porcine eyes were used. Activities of ACE1 and ACE2 and their inhibition by bioactive tripeptides (Ile-Pro-Pro, Val-Pro-Pro, Leu-Pro-Pro) as well as by a standard ACE-inhibitor captopril were assayed in the vitreous body, the retina and the ciliary body using fluorometric detection methods.Activity of ACE1 as well as…
Color Doppler imaging of the eye and orbit A synopsis of a 400 case experience
2009
Color Doppler imaging (CDI) is a recent advance in ultrasonography that allows simultaneous two-dimensional imaging of structure and blood flow. Doppler information is superimposed in color over a conventional gray-scale ultrasound image. Using this technique we have examined 400 eyes. The central retinal artery, posterior ciliary arteries, ophthalmic artery, the central retinal vein and the vortex veins could be located in all normal eyes. Using the color image as a guide, Doppler spectral analysis is used for quantitative assessment of blood flow velocity in these vessels. We also studied patients with intraocular tumors, arterial and venous retinal occlusions, orbital vascular anomalies …
Radiäre Optikusneurotomie (RON) bei retinalen Zentralvenenverschlüssen
2007
Background Compression in the lamina cribrosa is discussed as a reason for central retinal vein occlusion. Radial optic neurotomy should release the pressure and increase venous blood outflow. Patients and methods In a clinical trial 27 eyes with central retinal vein occlusion (22 eyes with clinical ischaemia, 5 eyes with continuous disc oedema and visual acuity below 4/10) underwent surgical decompression by vitrectomy and radial optic neurotomy. During surgery the intravenous pressure in the central vein was tested by infusion dynamometry before and right next to the incision. Follow up-time minimally was 1.5 years. Results Infusion dynamometry demonstrated a decrease of the central vein …