Search results for "Reviews"

showing 10 items of 304 documents

Advances in Targeting Signal Transduction Pathways

2012

// James A. McCubrey 1 , Linda S. Steelman 1 , William H. Chappell 1 , Lin Sun 1,2 , Nicole M. Davis 1 , Stephen L. Abrams 1 , Richard A. Franklin 1 , Lucio Cocco 3 , Camilla Evangelisti 4 , Francesca Chiarini 4 , Alberto M. Martelli 3,4 , Massimo Libra 5 , Saverio Candido 5 , Giovanni Ligresti 5 , Grazia Malaponte 5 , Maria C. Mazzarino 5 , Paolo Fagone 5 , Marco Donia 5 , Ferdinando Nicoletti 5 , Jerry Polesel 6 , Renato Talamini 6 , Jorg Basecke 7 , Sanja Mijatovic 8 , Danijela Maksimovic-Ivanic 8 , Michele Milella 9 , Agostino Tafuri 10 , Joanna Dulinska-Litewka 11 , Piotr Laidler 11 , Antonio B. D’Assoro 12 , Lyudmyla Drobot 13 , Kazuo Umezawa 14 , Giuseppe Montalto 15 , Melchiorre Cer…

cancer stem cellsAMPKtherapy resistanceReviewsLibrary scienceAntineoplastic AgentsrafBiologyPI3Kampk03 medical and health sciences0302 clinical medicineCANCER STEM CELLSNeoplasmsAnimalsHumansUniversity medicalMolecular Targeted TherapyAkt; AMPK; Cancer stem cells; Metformin; MTOR; PI3K; Raf; Targeted therapy; Therapy resistanceTreatment resistanceProtein Kinase Inhibitors030304 developmental biology0303 health sciencesRoswell Park Cancer InstituteAktCancer stem cellAKTMTORAMP-ACTIVATED PROTEIN KINASE (AMPK)Raftargeted therapyMetformin3. Good healthGene Expression Regulation NeoplasticCell stressOncologyDrug Resistance NeoplasmDrug Designtargeted therapy; metformin; therapy resistance; pi3k; akt; ampk; cancer stem cells; raf; mtor030220 oncology & carcinogenesisMutationmTORMolecular targetsCancer researchmetforminSignal Transduction
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STEM CELLS FOR TREATMENT OF CARDIOVASCULAR DISEASES: AN UMBRELLA REVIEW OF RANDOMIZED CONTROLLED TRIALS

2021

AIMS:\ud \ud Stem cells are a promising therapy for various medical conditions. The literature regarding their adoption for the clinical care of cardiovascular diseases (CVD) is still conflicting. Therefore, our aim is to assess the strength and credibility of the evidence on clinical outcomes and application of stem cells derived from systematic reviews and meta-analyses of intervention studies in CVD.\ud \ud METHODS and RESULTS:\ud \ud Umbrella review of systematic reviews with meta-analyses of randomized controlled trials (RCTs) using placebo/no intervention as control group. For meta-analyses of RCTs, outcomes with a random-effect p-value< 0.05, the GRADE (Grading of Recommendations Ass…

cardiovascular disease; meta-analysis; randomized controlled trials; stem cells; umbrella review0301 basic medicineUmbrella review.Agingmedicine.medical_specialtyMyocardial InfarctionStem cellsPlaceboBiochemistrylaw.invention03 medical and health sciencesUmbrella review0302 clinical medicineRandomized controlled triallawIntervention (counseling)medicineHumansMeta-analysicardiovascular diseasesMyocardial infarctionIntensive care medicineMolecular BiologyRandomized Controlled Trials as TopicStem cellbusiness.industrymedicine.diseaseCardiovascular diseaseIntervention studiesMeta-analysisCardiovascular diseases030104 developmental biologySystematic reviewAN UMBRELLA REVIEW OF RANDOMIZED CONTROLLED TRIALS.- Ageing research reviews ss.101257 2021 [Demurtas J. Fanelli G. N. Romano S. L. Solari M. Yang L. Soysal P. Sánchez G. F. L. Grabovac I. Smith L. Zorzi A. et al. -STEM CELLS FOR TREATMENT OF CARDIOVASCULAR DISEASES]NeurologyCardiovascular DiseasesRandomized controlled trialMeta-analysisCardiovascular disease; Meta-analysis; Randomized controlled trials; Stem cells; Umbrella review; Humans; Randomized Controlled Trials as Topic; Stem Cells; Cardiovascular Diseases; Myocardial InfarctionRandomized controlled trialsCardiovascular disease; Stem cells; Umbrella review; Meta-analysis; Randomized controlled trialsStem cellbusiness030217 neurology & neurosurgeryBiotechnology
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Kilpailijat hyvyyden markkinasektorilla

2018

charityeconomyhyväntekeväisyyskirja-arvostelutpovertytalousbook reviewsta5142kirja-arviotköyhyysJanus Sosiaalipolitiikan ja sosiaalityön tutkimuksen aikakauslehti
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Physical activity and exercise in mild cognitive impairment and dementia::an umbrella review of intervention and observational studies

2020

Objectives:\ud \ud The aim of this umbrella review was to determine the effect of physical activity/exercise on improving cognitive and noncognitive outcomes in people with MCI (mild cognitive impairment) and dementia.\ud \ud Design:\ud \ud Umbrella review of systematic reviews (SR), with or without meta-analyses (MAs), of randomized controlled trials (RCTs) and observational studies.\ud \ud Settings and Participants:\ud \ud People with MCI or dementia, confirmed through validated assessment measures. Any form of physical activity/exercise was included. As controls, we included participants not following any prespecified physical activity/exercise intervention or following the same standard…

cognitionmedicine.medical_specialtyPhysical activity; cognition; dementia; mild cognitive impairment; physical exercise; umbrella review; Cognition; Exercise; Humans; Systematic Reviews as Topic; Cognitive Dysfunction; DementiaPhysical activity; cognition; dementia; mild cognitive impairment; physical exercise; umbrella reviewPhysical exerciselaw.invention03 medical and health sciencesmild cognitive impairmentCognition0302 clinical medicineRandomized controlled trialphysical exerciselawmental disordersMedicine and Health SciencesmedicineHumansDementiaCognitive Dysfunction030212 general & internal medicineAn Umbrella Review of Intervention and Observational Studies- JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION cilt.21 ss.1415-1428 2020 [Demurtas J. Schoene D. Torbahn G. Marengoni A. Grande G. Zou L. Petrovic M. Maggi S. Cesari M. Lamb S. et al. -Physical Activity and Exercise in Mild Cognitive Impairment and Dementia]ExerciseGeneral NursingPhysical activity physical exercise dementia mild cognitive impairment cognition umbrella reviewRISKGeriatricsumbrella reviewPhysical activitybusiness.industryHealth PolicyCognitionGeneral Medicinemedicine.diseaseStrictly standardized mean differencePhysical therapyDementiaObservational studyGeriatrics and GerontologyAlzheimer's diseasebusiness030217 neurology & neurosurgerydementiaSystematic Reviews as Topic
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Sp1 transcription factor interaction with accumulated prelamin a impairs adipose lineage differentiation in human mesenchymal stem cells: essential r…

2012

Abstract Lamin A (LMNA)-linked lipodystrophies may be either genetic (associated with LMNA mutations) or acquired (associated with the use of human immunodeficiency virus protease inhibitors [PIs]), and in both cases they share clinical features such as anomalous distribution of body fat or generalized loss of adipose tissue, metabolic alterations, and early cardiovascular complications. Both LMNA-linked lipodystrophies are characterized by the accumulation of the lamin A precursor prelamin A. The pathological mechanism by which prelamin A accumulation induces the lipodystrophy associated phenotypes remains unclear. Since the affected tissues in these disorders are of mesenchymal origin, we…

congenital hereditary and neonatal diseases and abnormalitiesLipodystrophySp1 Transcription FactorCellular differentiationAdipose tissueBiologyLMNAHumansProtein PrecursorsTranscription factorOriginal Articles and ReviewsAdipogenesisintegumentary systemSecretory VesiclesMesenchymal stem cellnutritional and metabolic diseasesNuclear ProteinsCell DifferentiationMesenchymal Stem CellsCell BiologyGeneral MedicineLamin Type ALipid MetabolismCell biologyExtracellular MatrixBiochemistryAdipose TissueGene Expression RegulationAdipogenesisDifferentiationMutationMesenchymal stem cellsTranscription factorStem cellExperimental modelsLaminDevelopmental BiologyStem cells translational medicine
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Markku Ruotsila, Vaalit ja konservatismin aaltoliike yhdysvaltalaisessa politiikassa

2019

Markku Ruotsila, Sydänmaiden kapina. Donald Trump, amerikkalainen konservatismi ja äärioikeiston nousu. Helsinki: Gaudeamus, 2018, 391 s.

conservatismpolitiikkakirja-arvostelutkirja-arviobook reviewskonservatismipoliticsUnited States of AmericaYhdysvallatKirja-arvostelut
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Arvokkaat arviot

2018

Pääkirjoitus. Editorial.

editoriallcsh:GN1-890lcsh:History (General) and history of Europeleading articleslcsh:Anthropologybook reviewspääkirjoituksetlcsh:GR1-950historialcsh:History (General)lcsh:D1-2009cultural researchlcsh:Folklorekirja-arvostelutlcsh:DpääkirjoitushistorykulttuurintutkimusJ@rgonia
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Valta, tulkinta ja eettisyys : historiantutkijan yhteiskunnallinen rooli

2018

Arvio teoksesta Lidman, Satu, Anu Koskivirta & Jari Eilola (toim.). Historiantutkimuksen etiikka. Helsinki: Gaudeamus. 2017. 288 s. ISBN 978-952- 495-442-6. Book review: Lidman, Satu, Anu Koskivirta & Jari Eilola (toim.). Historiantutkimuksen etiikka. Helsinki: Gaudeamus. 2017. 288 s. ISBN 978-952- 495-442-6.

ethicalitylcsh:GN1-890lcsh:History (General) and history of Europeresearch ethicslcsh:Anthropologybook reviewslcsh:GR1-950lcsh:History (General)eettisyyslcsh:D1-2009ethicshistoriantutkimuslcsh:Folklorekirja-arvostelutlcsh:Dtutkimusetiikkahistorical researchetiikkabook review
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Book Review: The Palgrave international handbook of football and politics

2020

footballpolitiikkakirja-arvostelutjalkapallopolitical sciencebook reviewspolitics
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Dual Information Systems : A Review Of Factors Affecting Their Use

2019

More and more information systems (IS) are designed to address a blend of hedonic and utilitarian purposes, and hence become what information system scholars call today “dual systems.” The aim of this research is chiefly to provide a holistic perspective for research done regarding dual IS (i.e., what factors affect users’ adoption and post-adoption of these systems) in order to assess the state of knowledge in this area and to provide a reference point for system designers. To achieve this goal, we started out with a systematic literature review (35 articles), and analyzed the articles in terms of their theoretical background, constructs and findings. The results suggest that there is an i…

influential factorshedonismutilitarianismutilitarismiuseinformation systemssystematic literature reviewshedonismikäyttötietojärjestelmät
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