Search results for "Reward"
showing 10 items of 200 documents
Effects of acute social stress on the conditioned place preference induced by MDMA in adolescent and adult mice
2014
Exposure to social defeat stress increases the rewarding effects of psychostimulants in animal models, but its effect on 3,4-methylenedioxymethylamphetamine (MDMA) reward has received little attention. In the present study, we evaluated the influence of social defeat on the rewarding effects of MDMA in adolescent [postnatal day (PND) 29-40] and adult (PND 50-61) male mice using the conditioned place preference paradigm. Experimental mice were exposed to social defeat in an agonistic encounter before each session of conditioning with 1.25 or 10 mg/kg of MDMA. The effects of social defeat on corticosterone levels and the motor or the anxiogenic effects of MDMA were also evaluated. Mice expose…
'Up-regulation of histone acetylation induced by social defeat mediates the conditioned rewarding effects of cocaine
2016
Social defeat (SD) induces a long-lasting increase in the rewarding effects of psychostimulants measured using the self-administration and conditioned place procedures (CPP). However, little is known about the epigenetic changes induced by social stress and about their role in the increased response to the rewarding effects of psychostimulants. Considering that histone acetylation regulates transcriptional activity and contributes to drug-induced behavioral changes, we addressed the hypothesis that SD induces transcriptional changes by histone modifications associated with the acquisition of place conditioning. After a fourth defeat, H3(K9) acetylation was decreased in the hippocampus, whil…
Rewarding effects of 3,4-methylenedioxymethamphetamine (“Ecstasy”) in dominant and subordinate OF-1 mice in the place preference conditioning paradigm
2006
We tested the ability of 3,4-methylenedioxymethamphetamine (MDMA) to induce conditioned place preference (CPP) in dominant and subordinate OF-1 mice subjected to cohabitation and repeated sessions of agonistic confrontation, as well as in non-confronted mice. We selected doses of MDMA (2, 6, 10 mg/kg) previously reported to induce CPP in mice and we measured expression of c-Fos evoked by the treatments in non-confronted mice. MDMA induced c-Fos protein in several corticolimbic regions involved in drug-induced reward. Mice were exposed to brief sessions of agonistic confrontation on 5 consecutive days. Determinations of circulating hormones and drug conditioning tests were carried out on com…
Common Neural Mechanisms of Palatable Food Intake and Drug Abuse: Knowledge Obtained with Animal Models
2019
Eating is necessary for survival, but it is also one of the great pleasures enjoyed by human beings. Research to date shows that palatable food can be rewarding in a similar way to drugs of abuse, indicating considerable comorbidity between eating disorders and substance-use disorders. Analysis of the common characteristics of both types of disorder has led to a new wave of studies proposing a Gateway Theory of food as a vulnerability factor that modulates the development of drug addiction. The homeostatic and hedonic mechanisms of feeding overlap with some of the mechanisms implicated in drug abuse and their interaction plays a crucial role in the development of drug addiction. Studies in…
Influence of the Novelty-Seeking Endophenotype on the Rewarding Effects of Psychostimulant Drugs in Animal Models
2015
Novelty seeking (NS), defined as a tendency to pursue novel and intense emotional sensations and experiences, is one of the most relevant individual factors predicting drug use among humans. High novelty seeking (HNS) individuals present an increased risk of drug use compared to low novelty seekers. The NS endophenotype may explain some of the differences observed among individuals exposed to drugs of abuse in adolescence. However, there is little research about the particular response of adolescents to drugs of abuse in function of this endophenotype, and the data that do exist are inconclusive. The present work reviews the literature regarding the influence of NS on psychostimulant reward…
Behavioral and Neural Arguments of Motivational Influence on Decision Making During Uncertainty
2020
The scientific world is increasingly interested in motivation, primarily due to the suspected impact on decision-making abilities, particularly in uncertain conditions. To explore this plausible relationship, 28 healthy participants were included in the study and performed decision-making and motivational tasks while their neural activity was recorded. All participants performed the Iowa Gambling Task (IGT) and were split into two groups based on their score, one favorable group with 14 participants who performed advantageously and one undecided group with 14 participants who failed to develop the correct strategy on the IGT. In addition, all participants performed the Effort Expenditure fo…
On the drivers of successful crowdfunding: The case of the platform Verkami
2021
This article analyzes the determinants of successful crowdfunding initiatives using a sample of 5,251 projects from the reward-based Spanish platform Verkami. In contrast to most of the literature that has measured success with a dichotomous variable, we approach success with a continuous one, namely the ratio of achievement, which is measured as the obtained resources over the total amount requested by the promoter. We consider a set of potential determinants of success, which are theoretically well-grounded and cover a variety of spheres related to project features. Results suggest that factors related to the signaling theories such as partnership, having previous experience and interact…
La vulgarisation scientifique et les doctorants : mesure de l'engagement, exploration d'effets sur le chercheur
2018
We ask two questions: what are the factors that influence researchers’ public engagement activities (PEA)? And what are the impacts of these activities on the researcher? After presenting a historical overview of PEA, we analyze 20 surveys carried out between 1967 and 2014. We identify some global trends: PEA is generally positively perceived, researcher’s engagement is occasional but robust. Besides those trends some differences appear between studies based on theoretical models and empirical studies: the latter report complaints such as lack of time or lack of recognition, whereas theoretical-based ones challenge these statements.To further explore our two questions, we used two approache…
Integration of Peripheral Adiposity Signals and Psychological Controls of Appetite
2007
Publisher Summary This chapter presents an overview of the major anatomical and neurochemical participants in brain reward circuitry. It also elaborates the evidence available to date that supports the hypothesis that energy regulatory signals can modulate food reward. Psychological modulation of feeding involves taste hedonics and preferences, and the rewarding aspects of food. The brain circuitries implicated in stimulus reward, and in the regulation of energy balance, have traditionally been considered as separate. However, more recently, accumulated evidence suggests that there is both anatomical and functional crosstalk between these sets of central nervous system (CNS) circuitry. Addi…
How to unleash the innovative work behavior of project staff? The role of affective and performance-based factors
2017
Abstract Although the literature generally presumes that temporary forms of organizing such as projects are especially suitable for generating innovation, empirical support for this assumption that goes beyond case-based evidence is still scarce. The study at hand aims to close this gap in research by investigating how the characteristics of temporary organizations (TOs) affect an individual's innovative work behavior (IWB). By applying a structural equation modeling approach on an Austrian-German sample of 583 TO professionals, it can be shown that both, performance-based factors and affective factors are having a significant impact on the emergence of IWB. However, the hypothesized modera…